Chemistry (Theses and Dissertations): Recent submissions
Now showing items 141-160 of 435
-
Synthesis and application of large-area graphene stacks
(Trinity College (Dublin, Ireland). School of Chemistry, 2015)Research of two-dimensional nanomaterials has been significant since the discovery of graphene in 2004. Really one or few atoms thick but often micrometres in lateral size, these materials exhibit unique properties such ... -
Novel lanthanide luminescent materials : sensing in solution and on solid surfaces
(Trinity College (Dublin, Ireland). School of Chemistry, 2012)This thesis entitled "Novel Lanthanide Luminescent Materials: Sensing in Solution and on Solid Surfaces" is divided into seven chapters. Chapter 1, the introduction, is divided into two sections. The first half introduces ... -
Multimodal magnetic nanostructures
(Trinity College (Dublin, Ireland). School of Chemistry, 2009)The objectives of this thesis are to develop new iron oxide and cobalt ferrite (CoFe2O4) based nanocomposites and their fluorescent-magnetic derivatives with a range of potential biomedical applications. The major aims ... -
The design of artificial enzymes, novel chiral organocatalysts and new ligation technologies
(Trinity College (Dublin, Ireland). School of Chemistry, 2013)An investigation into the mode of action of aldehyde dehydrogenase enzymes was undertaken through the synthesis of a series of compounds that were hypothesised as potential biomimetics. This study revealed the possible ... -
Design of a novel family of bifunctional phase-transfer catalysts and their applications in the kinetic resolution of 2-oxindole derivatives
(Trinity College (Dublin, Ireland). School of Chemistry, 2015)The design and synthesis of a biomimetic organocatalyst mimicking the active site of aspartate proteases have been undertaken. The design was aimed at constructing an artificial enzyme bearing two carboxylic acid groups ... -
Investigation of LiMo3Se3 nanowires, nanowire networks and ion-exchanged X+ {Mo3Se3}- networks
(Trinity College (Dublin, Ireland). School of Chemistry, 2011)With the limits of current silicon processing techniques drawing nearer, the "bottom up" approach for future technologies has become a focus of major research worldwide. This requires detailed studies of possible replacement ... -
Electronic structure studies of p-type semiconducting oxides
(Trinity College (Dublin, Ireland). School of Chemistry, 2011)Transparent conducting oxides (TCOs) are a unique class of materials which combine the normally mutually exclusive properties of transparency and conduction. Despite the many applications and widespread interest in TCO ... -
Novel nanoscale phenomena on Si(100). STM and DFT investigation of nanoscale contract and molecular adsorption
(Trinity College (Dublin, Ireland). School of Chemistry, 2009)Prompted by the limited information that might be harnessed en route to the rational design of molecular scale electronic devices, the research undertaken within this thesis is concerned with the self assembly mechanisms ... -
Studies on the Catalytic Asymmetric Synthesis of Terminal Expoxides from Aldehydes
(Trinity College (Dublin, Ireland). School of Chemistry, 2012)Chiral non racemic terminal epoxides are among most the valuable building blocks available to an organic chemist. The Johnson-Corey-Chaykovksy epoxidation (JCC) of carbonyl compounds is a promising and complementary approach ... -
Studies on asymmetric organocatalytic processes: desymmetrisation, kinetic resolution and dynamic kinetic resolution
(Trinity College (Dublin, Ireland). School of Chemistry, 2011)The design and synthesis of small organic molecules which effectively mimic the hydrogen-bonding capabilities of enzymes has recently become a flourishing branch of the fascinating, emerging area of organocatalysis. Herein ... -
The development of a new class of C-5' substituted cinchona alkaloid derivatives as efficient organocatalysts
(Trinity College (Dublin, Ireland). School of Chemistry, 2013)Over the past three decades, the synthesis of enantiomerically pure products became a major concern in modem research. In this context, organocatalysis has emerged as a viable method and interest in this field has intensified ... -
Studies on the acyloin reaction : development of novel N-heterocyclic carbene catalysts
(Trinity College (Dublin, Ireland). School of Chemistry, 2010)The benzoin condensation reaction involves the catalytic dimerisation of two aldehydes to yield acyloins (a-hydroxy ketones), which are highly useful building blocks for the synthesis of heterocycles, natural products, ... -
A synthetic and photophysical study of ruthenium polypyridyl enantiomers binding to DNA
(Trinity College (Dublin, Ireland). School of Chemistry, 2012)The luminescent ONA probe [Ru(phen)2dppz]2+, ruthenium (bis-1,10-phenanthroline dipyrido[3,2-a:2',3'-c]phenazine, was the first tris-bidentate ruthenium complex to be shown unequivocally to intercalate to DNA, which it ... -
The rational design and synthesis of novel a-2 andrenoceptor antagonists as potential antidepressants
(Trinity College (Dublin, Ireland). School of Chemistry, 2011)Depression is one of the leading causes of illness worldwide and has been closely linked to low concentrations of monoaminergic neurotransmitters in the brain. Activation of presynaptic alpha-2 adrenoceptors (a2-AR) by the ... -
Carbon nanotube-polymer composites
(Trinity College (Dublin, Ireland). School of Chemistry, 2009)Since their discovery in 1991, carbon nanotubes have generated a lot of activity in many areas of science and engineering due to their unprecedented superlative mechanical, thermal and electronic properties. This combination ... -
Sugars, thiosugars and thiophenes
(Trinity College (Dublin, Ireland). School of Chemistry, 2009)This project was concerned with expanding and exploiting the proven medical potential of 4'-thionucleosides analogues (4'-TNAs), with the long term aim of providing improved treatments for viral, bacterial and cancer based ... -
Towards the fixation, storage and activation of carbon dioxide using iminodiacetic acid-based coordination compounds
(Trinity College (Dublin, Ireland). School of Chemistry, 2015)The main purpose of the current study was to expand, and fully explore, the library of known coordination compounds that form from the aqueous hpdta reaction system. The study examines the role hpdta coordination compounds ... -
Ferrocene containing polyaromatic hydrocarbons and the formation of a discotic nitrogen-heterosuperbenzene
(Trinity College (Dublin, Ireland). School of Chemistry, 2009)Chapter 1 describes the synthesis and characterisation of a series of novel ferrocene containing polyphenylene compounds. These consist of polyphenylene molecules containing one, two, four and six ferrocene moieties. Also ... -
Studies on the design of novel organocatalysts for reduction, carbonyl protection and asymmetric acylation reactions
(Trinity College (Dublin, Ireland). School of Chemistry, 2010)Due to the vast number of biologically active compounds bearing a hydrogen substituent as a part of the stereogenic center, the development of efficient reduction reactions has been a main focus within the area of asymmetric ... -
Synthesis and biological activity of 9-Azapaullone, its N-oxide and N-benzyl derivatives
(Trinity College (Dublin, Ireland). School of Chemistry, 2011)Cancer is a serious and life-threatening disease that accounts for 13% of deaths each year. It is a complicated process with many factors and variations observed, however research has uncovered many new strategies for the ...
