Chemistry (Theses and Dissertations): Recent submissions
Now showing items 161-180 of 435
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The synthesis, characterisation and photophysical properties of novel tri-substituted-8-azafluoranthene compounds and their Cu(1) complexes
(Trinity College (Dublin, Ireland). School of Chemistry, 2012)Chapter 1: This chapter details the synthesis and charaeterisation of a family of novel tri-substituted-8-azafluoranthene eompounds that have N^N bidentate ligand capabilities. The compounds are synthesised via a Diels-Alder ... -
Bipyridyl alkynyl-based polyphenylenes : tuning photoluminescence in metal-organic chromophores
(Trinity College (Dublin, Ireland). School of Chemistry, 2011)Chapter 1 introduces two series of novel polyphenylene molecules with inherent ligand functionality. These are prepared via a sequence of Sonogashira cross-coupling reactions and [2+4] Diels-Alder cycloadditions and are ... -
Synthesis and evaluation of dinuclear cyclen-based lanthanide complexes for the hydrolysis of phosphodiester bonds
(Trinity College (Dublin, Ireland). School of Chemistry, 2010)This thesis, entitled, "Synthesis and Evaluation of Cyclen-based Lanthanide Complexes for the Hydrolysis of Phosphodiester Bonds" is composed of five Chapters. In the first Chapter the structural importance of phosphodiester ... -
Synthesis and evaluation of cyclen-based lanthanide complexes for luminiscent sensing and as MRI contrast agents
(Trinity College (Dublin, Ireland). School of Chemistry, 2010)This thesis entitled "The Synthesis and Evaluation of Cyclen Based Lanthanide Complexes for Luminescent Sensing and as MRI Contrast Agents" is composed of five chapters. In the first chapter the photophysical properties ... -
Combined scanning tunneling microscopy (STM) & surface stress measurements (SSM) of chemical reactions on semiconductor surfaces : oxidation of the Si(111)-(7x7)surface
(Trinity College (Dublin, Ireland). School of Chemistry, 2012)A novel combined scanning tunneling microscopy (STM) and surface stress measurement (SSM) system has been developed to allow absorbate-induced changes in surface stress to be measured and related to the structural and ... -
Conformationally restricted and Bis-aryl guanidinium derivatatives : towards imroved Alpha2-adrenergic affinity and antagonism for the treatment of depression
(Trinity College (Dublin, Ireland). School of Chemistry, 2015)The evident necessity to develop novel therapeutics to treat depression has been recently highlighted by the World Health Organisation who has listed depression to be the second largest global health burden by the year ... -
Conductance probe microscopy investigation on the local electronic properties of single walled carbon nanotube systems
(Trinity College (Dublin, Ireland). School of Chemistry, 2010)In order to build electronic devices and circuits comprised of nanoscale materials as the active element it is imperative to unravel the local electronic properties of these materials. We have performed an in-depth study ... -
A computational exploration of a possible alternative to nucleotides as the basis of a genetic alphabet
(Trinity College (Dublin, Ireland). School of Chemistry, 2012)One of the most fundamental questions in molecular biology is why nature has chosen Adenine (A), Cytosine (C), Guanine (G), Uracil (U)/Thymine (T) for the genetic alphabet. Although much is known about the structure and ... -
Synthesis, characterization and activity evaluation of novel spiropyran-based ion sensors
(Trinity College (Dublin, Ireland). School of Chemistry, 2011)Photochromism indicates a reversible transformation of a single chemical species induced in one or both directions by electromagnetic radiation between two states having different absorption spectra. Photochromic compound ... -
Synthesis, biophysical and biochemical studies of new guanidine-like derivatives targeting DNA
(Trinity College (Dublin, Ireland). School of Chemistry, 2010)The literature describes many DNA minor groove binders, some of them having similar characteristics such as crescent shape, being dicationic and containing hydrogen bond donating or accepting groups. -
An investigation into the catalytic versatility of low toxicity azolium ions
(Trinity College (Dublin, Ireland). School of Chemistry, 2013)A somewhat unexpected observation made by our group that appropriately substituted pyridinium ions were capable of acting as Bronsted acid catalysts in the presence of protic additives (i.e. methanol) caught our attention. ... -
Design, synthesis and photophysical evaluation of novel 1 ,8-naphthalimide Tröger's base derivatives
(Trinity College (Dublin, Ireland). School of Chemistry, 2012)This thesis entitled 'Design, Synthesis and Photophysical Evaluation of Novel 1,8- Naphthalimide Based Troger's Bases' is divided into five chapters. The first chapter provides a brief description of the structure of DNA ... -
Lanthanide luminescent self-assembly complexes : from solution studies to mechanical sensing on gold surfaces
(Trinity College (Dublin, Ireland). School of Chemistry, 2009)This thesis entitled "Lanthanide Luminescent Self-Assembly Complexes: From Solution Studies to Mechanical Sensing on Gold Surfaces" is divided into five Chapters. Chapter 1 gives a detailed account of lanthanide-based ... -
Luminescent and paramagnetic lanthanide based complexes as biological probes and diagnostic imaging agents
(Trinity College (Dublin, Ireland). School of Chemistry, 2011)This thesis entitled "Luminescent and Paramagnetic Lanthanide Based Complexes as Biological Probes and Diagnostic Imaging Agents" is divided into seven chapters. Chapter 1, the introduction, is divided into two sections. ... -
Targeting DNA : synthesis, biophysical and biochemical studies of new aminoalkyl derivatives of diphenyl guanidines and acridine
(Trinity College (Dublin, Ireland). School of Chemistry, 2012)Research on the design and synthesis of DNA targeting molecules is widespread. There are a number of diseases which are treated using DNA-targeting agents. DNA ligands have been shown to exhibit anticancer, antiprotozoal, ... -
Fabrication and characterisation of micro- and nano- structures with high aspect ratio
(Trinity College (Dublin, Ireland). School of Chemistry, 2011)The main aim of the work presented in this thesis was to develop novel high aspect ratio micro- and nano- structures by using metal alkoxide derived sol-gels and polymer solutions and infiltrating them into porous templates. ... -
The synthesis of analogues of mecamylamine
(Trinity College (Dublin, Ireland). School of Chemistry, 2013)The anti-hypertensive drug MA (Inversine®) has been investigated for and shown antiaddictive and anti-depressive properties, in both human subjects and animal models. Due to its restrictive synthesis, structure-activity ... -
Studies on the use of anhydrides in novel catalytic asymmetric transformations
(Trinity College (Dublin, Ireland). School of Chemistry, 2013)In this thesis the possibility of using bifunctional cinchona alkaloid-derived organocatalysts to promote the enantioselective cycloaddition reaction of enolisable anhydrides to various electrophiles to form annulated ... -
Synthesis of mecamylamine analogues
(Trinity College (Dublin, Ireland). School of Chemistry, 2010)This project was concerned with the synthesis of structural analogues of the neuronal nicotinic acetylcholine receptor (nAChR) antagonist mecamylamine (MA). MA was used clinically as an antihypertensive compound since the ... -
Informational patterns in the genetic code : a chemical and informatics perspective
(Trinity College (Dublin, Ireland). School of Chemistry, 2010)The genetic code has been the subject of extensive investigation for over 50 years. In this research, we have employed various methods to derive empirical determinations of the informational characteristics of this biological ...
