RSS 1.0Physiology (Theses and Dissertations)
Recent Submissions
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Investigating the influence of sex differences on modulation of neuroinflammation in the mouse by aerobic exercise
(Trinity College Dublin. School of Medicine. Discipline of Physiology, 2025)Exercise has long been viewed as an 'all-in-one' therapeutic approach by preserving and improving health and reducing the risk of age-associated noncommunicable metabolic, cardiovascular and neurodegenerative diseases ... -
Regional specific modulation of neuronal activation associated with the antidepressant-related properties of neuronal nitric oxide synthase (nNOS) inhibitors
(Trinity College (Dublin, Ireland). Department of Physiology, 2016)Depression is a significant health problem in today’s society and when left untreated can be a devastating illness. Current antidepressant treatments are far from ideal as several weeks are required for a therapeutic effect, ... -
Protective effects of noradrenergic and neurotrophic signalling on neuronal complexity in vitro
(Trinity College (Dublin, Ireland). Department of Physiology, 2016)Neuronal atrophy and synaptic dysfunction are prevalent features of a range of neurological disorders. Degeneration of neurites and loss of synaptic connections often precede cell loss during neurodegeneration and the ... -
Analysis of the metabolic shift that accompanies differential activation of microglia
(Trinity College (Dublin, Ireland). Department of Physiology, 2017)Microglia, the resident immune cells of the central nervous system (CNS), adopt different phenotypes upon activation by different stimuli. The primary role of microglia is protection and maintenance of homeostasis, and any ... -
Excercise and TrkB activation as neuroprotectants in mouse models of age and neuroinflammation : an assessment of underlying mechanisms
(Trinity College (Dublin, Ireland). Department of Physiology, 2017)The processes of learning and memory concern themselves primarily with the hippocampus - one of two exclusive cortical regions where neurogenesis has been found to take place. These cognitive processes are themselves ... -
Elucidating the therapeutic potential of Q8 in Glioblastoma Multiforme
(Trinity College Dublin. School of Medicine. Discipline of Physiology, 2024)Glioblastoma multiforme (GBM) is the most common and aggressive form of brain cancer in humans. Despite advancements in treatment and care, patient outcomes and survival rates are abysmal, with a five-year survival rate ... -
Investigating the Immune System in Parkinson's Disease
(Trinity College Dublin. School of Medicine. Discipline of Physiology, 2024)In 1817 James Parkinson first described the symptoms of the Parkinson's disease (PD). It is the second most common neurodegenerative disease worldwide, and cases are rising exponentially. Characteristic hallmarks of PD ... -
Investigating the therapeutic utility of Olaparib in Metachromatic Leukodystrophy and Krabbe Disease
(Trinity College Dublin. School of Medicine. Discipline of Physiology, 2024)Leukodystrophies encompass a diverse group of genetically-based disorders that impact the development and preservation of myelin in the central nervous system's white matter. These conditions, affecting approximately 1 in ... -
The Impact and Influence of Sports Related Concussion and Cardiovascular Risk Factors on Brain and Heart Health across an Ageing Population
(Trinity College Dublin. School of Medicine. Discipline of Physiology, 2023)This study focused on the relationship between perceptual performance, brain health, and cardiovascular (CV) profiles in both recreational athletes and non-athletes, bridging the gap between sensory integration, cognitive ... -
Identifying the therapeutic potential of novel compounds in the treatment of Glioblastoma Multiforme
(Trinity College Dublin. School of Medicine. Discipline of Physiology, 2023)Glioblastoma multiforme (GBM) is the most common and aggressive brain cancer in adults with a dismal 5-year survival rate of <5%. Despite advanced diagnostic and multimodal treatments including surgery, followed by ... -
Antipsychotics Prevent Psychosine Induced Toxicity in Glial Cells.
(Trinity College Dublin. School of Medicine. Discipline of Physiology, 2023)Glial cells are implicated in the neuropathophysiology of schizophrenia and other neuropsychiatric disorders. Also, the role of altered myelin in the onset and development of schizophrenia and changes in myelin due to ... -
Central and peripheral characterisation of TLR7/8 and endocannabinoid signalling in multiple sclerosis
(Trinity College Dublin. School of Medicine. Discipline of Physiology, 2022)Toll-like receptors (TLRs) are a class of pattern-recognition receptors (PRRs) involved in initiating an immune response to infection or endogenous damage. These receptors are expressed on cells of both the innate and ... -
Effects on an acute priming exercise and high-intensity interval training on oxygen uptake and muscle deoxygenation kinetics in older individuals with type 2 diabetes
(Trinity College Dublin. School of Medicine. Discipline of Physiology, 2021)Peak oxygen uptake (V̇O2peak) is consistently reduced in individuals with type 2 diabetes (T2D) of all ages compared with non-diabetic (ND) controls. In middle-aged (between 45 to 60 y) individuals with T2D these reductions ... -
The interactions of apolipoprotein E and inflammation in human iPSC-derived astrocytes
(Trinity College Dublin. School of Medicine. Discipline of Physiology, 2020)Alzheimer’s disease (AD) is a devastating neurodegenerative disease characterised histologically by the presence of extracellular plaques and intracellular neurofibrillary tangles, and clinically by memory ... -
Targeting the Sphingosine 1-Phosphate Axis as a Therapeutic Strategy in Krabbe's Disease: A Pre-Clinical Study.
(Trinity College Dublin. School of Medicine. Discipline of Physiology, 2020)Krabbe's disease (KD, globoid cell leukodystrophy) is a rare infantile neurodegenerative disorder, caused by the defective gene galc encoding the lysosomal hydrolase galactosylceramidase (GALC). A subsequent decreased ... -
Assessing Toll-like receptor 3/4 signalling as a phytocannabinoid target in immune cells
(Trinity College Dublin. School of Medicine. Discipline of Physiology, 2020)Toll-like receptors (TLRs) are the sensors of pathogen associated molecules that trigger tailored innate immune intracellular signalling responses. TLRs are expressed on cells of the immune system and play an important ... -
Investigating the Effects of FTY720 on Spatial Memory and Neuroinflammation in a Rodent Model of Alzheimer's Disease
(Trinity College Dublin. School of Medicine. Discipline of Physiology, 2020)Alzheimer's disease (AD) is a progressive, age-related neurodegenerative disorder characterized by memory loss and cognitive decline, with loss of global functioning over time eventually leading to death. At the molecular ... -
Targeting the noradrenergic system for anti-inflammatory and neuroprotective actions in an animal model of Parkinson's disease
(Trinity College (Dublin, Ireland). Department of Physiology, 2015)Parkinson's disease (PD) is a common neurodegenerative disorder that is characterised by the selective loss of dopamine (DA) neurons within the substantia nigra pars compacta and results in reduced striatal DA input ... -
The role of S1P receptors and their interacting proteins in Krabbe Disease
(Trinity College (Dublin, Ireland). Department of Physiology, 2015)Globoid cell leukodystrophy (Krabbe disease, KD) is a rare autosomal recessive neurodegenerative disorder that presents within the first six months of life and is usually fatal by the age of two years. KD is caused by a ... -
The effect of excercise and pioglitazone on the dynamic responses of oxygen uptake and leg vascular conductance in males with type 2 diabetes
(Trinity College (Dublin, Ireland). Department of Physiology, 2012)The exercise capacity of an individual with T2D is often reduced due to the effects of T2D upon oxygen consumption- (VO2) and vascular conductance (VC)- kinetics. Exercise training has been shown to induce improvements in ...
