Psychiatry (Theses and Dissertations): Recent submissions
Now showing items 21-40 of 75
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Molecular pathways of depression and antidepressant therapies for treatment resistant depression
(Trinity College Dublin. School of Medicine. Discipline of Psychiatry, 2020)According to the World Health Organisation, depression is the most common psychiatric disorder. Despite this, the pathophysiology of depression is unclear. Electroconvulsive therapy (ECT) is the most acutely effective ... -
Assessing the effects of coenzyme QIO in schizophrenia & schizoaffective disorder: a randomised, placebo controlled trial
(Trinity College Dublin. School of Medicine. Discipline of Psychiatry, 2020)Background: Schizophrenia is a complex, heterogeneous, neurodevelopmental disorder. Cognitive impairments and negative symptoms such as avolition and asociality are prevalent in the majority of patients with a diagnosis ... -
The importance of cognitive deficits for forensic mental health patients with schizophrenia or schizoaffective disorder
(Trinity College Dublin. School of Medicine. Discipline of Psychiatry, 2020)Forensic Mental Health Services (FMHS) provide care and treatment to a minority of people with mental illness like schizophrenia or schizoaffective disorder, who come into contact with law enforcement agencies (Kennedy et ... -
Investigation of α-tubulins as translational biomarkers of major depressive disorder: indications for disease severity and treatment efficacy
(Trinity College Dublin. School of Medicine. Discipline of Psychiatry, 2020)Introduction: Major Depressive Disorder is a significant cause of disability worldwide. In a 2017 report, the World Health Organisation estimated that 320 million people suffered from depression globally. Although several ... -
Family-based association and molecular genetic analysis of genes implicated in the aetiology of autism
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2009)Autism is an early onset neurodevelopmental disorder affecting three core areas of behaviour - communication, social behaviour and restricted/repetitive behaviour. Although family and twin studies indicate a genetic ... -
Multimodal Approach to Endophenotype Discovery in Disorders with Genetic Liability
(Trinity College Dublin. School of Medicine. Discipline of Psychiatry, 2019)Neurodevelopmental and Neurodegenerative disorders constitute a huge weight on society in terms of human suffering and economic cost. In recent years an increasing amount of emphasis has been placed on investigating the ... -
An investigation of the role of antenatal depression, maternal cortisol and postnatal interactive behaviour on infant neurodevelopment in the first year of life.
(Trinity College Dublin. School of Medicine. Discipline of Psychiatry, 2019)Abstract Aims: Major Depressive Disorder (MDD) is the most prevalent psychiatric disorder during the perinatal period and can lasting adverse effects on maternal wellbeing and infant development. This aim of this thesis ... -
Molecular genetics investigations in autism
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2004)This research thesis involved the establishment and management of a research group in autism genetics in addition to the collection of an autism sample of parent-child trios. A well-characterised sample of individuals with ... -
The hippocampus, amygdala and their principal output tracts in major depressive disorder
(Trinity College Dublin. School of Medicine. Discipline of Psychiatry, 2019)Major depressive disorder is a common, debilitating illness. Despite its high prevalence rate and global disease burden, the biological mechanisms underlying this disorder remain largely unknown. Evidence points towards ... -
Caring for a child with an autistic spectrum disorder over the life span
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2003)Carers of children on the autistic spectrum have stressful lives (Randall & Parker, 1999). The aim of this study was to investigate the life of the carer, and in particular to examine how they have coped, their support ... -
Mental health in Northern Malawi : a cultural perspective
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2002)This thesis seeks to address a theoretical question: What is the experience of people with a mental disturbance, when they are introduced to a health care system which is ontologically distinct from their own cultural ... -
The molecular determinant of IGF-1(Mecasermin)action in Rett Syndrome Patients
(Trinity College Dublin. School of Medicine. Discipline of Psychiatry, 2018)Abstract This is a preliminary investigation of effects of insulin-like growth factor-1 (IGF-1) treatment on differential gene expression (DGE) of whole blood samples from Rett syndrome (RTT) patients. Samples were ... -
Symptoms of autism in ADHD : a familial trait in a subset of children with ADHD which correlates with comorbid oppositional defiant disorder, conduct disorder and motor disorder
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2009)Introduction; This study examines autism symptoms in a sample of children with ADHD, in their siblings, and in a control sample. Study sample: 821 children with ADHD, combined type who were participating in the International ... -
The contributions of knowledge and contact to the stigma of mental illness
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2008)Study One is a single face-to-face questionnaire study of 243 patients with psoriasis and/or arthritis. Because leprosy is an infectious condition, psoriasis is a better model of a stigmatising skin disorder likely to cause ... -
Subsyndromal depression and anxiety predictors, consequences and two year outcome in the Irish elderly
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2008)Depression is the commonest mental illness in late life and frequently occurs co- morbidly with anxiety. While all levels of illness severity have been reported a significant proportion of older adults suffer with clinically ... -
Electroconvulsive therapy for depression and ketamine for relapse prevention: factors affecting response, cognition and research participation
This thesis comprises five clinical research studies. Study 1. Pilot randomised controlled trial: Ketamine vs midazolam for depression relapse prevention following successful electroconvulsive therapy (ECT), the ... -
High dose right unilateral versus moderate dose bilateral ECT for major depression : time to re-orientation, physical functioning, quality of life and attitudes
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2012)The objective of this study was to compare the effects of 1.5 x seizure threshold (ST) bitemporal ECT with high dose (6 x ST) right unilateral (RUL) ECT with respect to immediate recovery from treatment, change in physical ... -
Bereavement and people with intellectual disabilities
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2007)For most people, the loss of a loved one is a tragedy unequalled by any other. It affects every family and raises policy and logistic issues for the health and social service agencies of every community. Currently, people ... -
The influence of Alzheimer's dementia on time spent caregiving for persons with Down Syndrome
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2003)Background: Persons with Down syndrome (DS) are at increased risk of Alzheimer’s type dementia (AD) when compared to the general population, yet little attention has been paid to the impact of the illness on such persons ... -
Electroconvulsive therapy for depression : optimising treatment and exploring molecular mechanisms
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2016)The objective of this project was to explore clinical and molecular aspects of electroconvulsive therapy (ECT) in the treatment of depression, with a particular focus on the role of microRNAs (small, non-coding molecules ...
