Psychiatry (Theses and Dissertations): Recent submissions
Now showing items 41-60 of 75
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Age-related hearing loss and neurocognitive function: Normal and pathological processes in cognitive ageing
(Trinity College Dublin. School of Medicine. Discipline of Psychiatry, 2018)This thesis investigates age-related hearing loss (ARHL) as a potential biomarker and risk factor for cognitive decline and dementia. Two reviews were conducted to examine the evidence for an association in the epidemiological ... -
The role of FKBP5 genetics and epigenetics in mediating the effects of early life adversity on emotional processing brain regions in major depressive disorder
(Trinity College Dublin. School of Medicine. Discipline of Psychiatry, 2018)Major depressive disorder (MDD) is the most widespread psychiatric illness and is characterized by loss of pleasure, depressed mood, sleep disturbances and anxiety. Recently, an inflammatory theory of MDD has emerged, which ... -
An investigation of the effect of maternal depression during pregnancy on maternal and infant hypothalamic-pituitary-adrenal axes
(Trinity College Dublin. School of Medicine. Discipline of Psychiatry, 2018)Background: Pregnancy is a period of increased vulnerability for developing depression. Several maternal physiological systems, including the hypothalamic-pituitary-adrenal (HPA) axis undergo changes during pregnancy. ... -
Investigating the effects of schizophrenia genome-wide associated variants on white matter microstructure and brain morphology using diffusion tenson imaging and quantitative MRI
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2014)This thesis describes four studies that aim to to elucidate the effects of schizophrenia genome-wide associated variants on measures of white matter microstructure, cortical thickness, surface area and subcortical volume. ... -
The effects of depression and electroconvulsive therapy on retrospective memory and general cognition : a longitudinal study
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2012)The objectives of this work were to investigate the effects of depression on retrospective memory, in addition to attention, psychomotor and executive function, in depressed patients receiving pharmacotherapy treatment ... -
Neuropsychosocial predictors of outcomes in opioid dependent patients post-detoxification
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2015)The current treatment of choice for most opiate dependent persons is long term substitute prescribing. Detoxification is not an effective stand-alone treatment. Given the weak evidence base for detoxification coupled with ... -
Implications of cortical structure and connectivity in autism spectrum disorder
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2015)Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterised by early-onset deficits in social communication and interaction together with recurrent restricted repetitive behaviours (APA, 2013). Insights ... -
Genetic and molecular studies of rare variation in schizophrenia
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2014)Schizophrenia (SCZ) is a severe and debilitating disorder and it has a worldwide prevalence estimated at approximately 1%. The underlying pathogenesis of SCZ is poorly understood and there is a great need for diagnostic ... -
Methodological issues in event-related fMRI
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2005)Functional magnetic resonance imaging (fMRI) is a very powerful tool for localising psychological functions to specific brain areas. Recently, there has been a surge of interest in determining the functional differences ... -
The impact of schizophrenia genome wide association study genes on functional connectivity : a functional magnetic resonance imaging study
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2014)Genome-wide association studies (GWAS) have identified several genetic variants associated with increased schizophrenia risk. However, the specific mechanisms by which these variants increase risk are not fully understood. ... -
Functional investigation of neurodevelopmental effects of DISC1 and related psychosis risk genes
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2015)Schizophrenia (SCZ) is a severe neurodevelopmental disorder, which affects about 1% of the population worldwide, and whose symptoms start during early adulthood. SCZ is determined by the interaction of genetic and environmental ... -
Phenotypic and molecular genetic analysis of autism
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2010)Autism is an early onset neurodevelopmental disorder affecting three core areas of behaviour - communication, social interaction and restricted repetitive behaviour. Although family and twin studies indicate a genetic ... -
Application of functional genomics to psychiatric disorders
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2012)Schizophrenia and bipolar disorder are common and severe psychiatric illnesses directly affecting approximately 1% of the population worldwide. Both have a devastating impact on the lives of those affected not to mention ... -
Frailty in an older population : the impact on community-dwelling elders, dementia patients and older caregivers
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2012)Frailty represents one of the greatest gerontological challenges faced by societies in coming years. Growing numbers of older citizens leads not only to increasing numbers of healthy elders, but also frail and disabled elders. -
Investigating risk factors and clinical correlates of copy number variants in Autism Spectrum Disorders and schizophrenia
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2013)Autism Spectrum Disorders (ASD) (OMIM 209850) and schizophrenia (OMIM 181510) are both complex neurodevelopmental disorders with extensive emotional and physical costs. Although there has been some progress in understanding ... -
Brain structure, function and connectivity in Autism Spectrum Disorders
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2012)In this study, two neuroimaging modalities were used to investigate neural connectivity in individuals with autism spectrum disorder; functional magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI). -
Electrophysiological event-related-potentials & their association with genome-wide-associated risk variants in schizophrenia
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2012)This thesis describes the use of electrophysiological event- related-potentials as a method for understanding, at the cortical level, the functional significance of putative schizophrenia susceptibility genes identified ... -
Functional neural differences in emotional regualtion between patients with MDD and healthy controls in the context of the vulnerability factors : family history of MDD, BDNF Val66Met polymorphism
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2012)Emotional regulation is a key mechanism which shows disturbances during major depressive disorder (MDD), and which may be modified by certain factors enhancing vulnerability to MDD. Two vulnerability factors were tested ... -
Characterisation of MACROD2, a putative autism susceptibility gene : translating Genome-Wide Analysis to causation
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2013)Genome Wide Association studies (GWAS) have been used to identify genetic markers which have strong statistical association with a disease. Establishing a functional consequence of association is required to determine a ... -
Fuctional and structural brain changes in ageing related to emotional processing
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2012)Of all mental abilities emotional processing is well-preserved in healthy ageing. In spite of this, the neural substrates of emotional processing in ageing are still not fully understood. In this project several experiments ...
