Psychiatry (Theses and Dissertations): Recent submissions
Now showing items 61-75 of 75
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The impact of schizophrenia genome-wide association study genes on neurocognition and social cognition : a behavioural study
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2013)Genome wide association studies (GWAS) have established numerous previously unidentified variants associated with increased risk for schizophrenia (SZ). Exactly how most of these variants exert their influence remains ... -
Investigation of glutamatergic synapse genes in schizophrenia susceptibility : from linkage to genome-wide association studies
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2011)Schizophrenia is a common and severe mental illness which is highly heritable. Susceptibility to schizophrenia is likely to be caused by multiple genetic variants in combination with environmental risk factors. The ... -
Investigation of rare sequence variants in putative susceptibility genes for schizophrenia and autism spectrum disorders
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2013)Schizophrenia (SZ) and Autism Spectrum Disorders (ASD) are complex neuropsychiatric disorders that have a very large health, societal and economic burden in Ireland. They affect approximately 1% and 0.8% of the population ... -
Neurocognitive changes in associative- and working memory with aging
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2010)This thesis sought to determine the nature of associative- and working memory dechne during adulthood, and to try and elucidate some of the factors which contribute to this age- related mnemonic decline. In the first study ... -
The aging brain : an investigation into cognitive training and resting state networks in healthy older adults
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2013)Investigating the complexities surrounding the aging brain is of vital importance if we are to fully understand the mechanisms of aging. A greater understanding of aging may perhaps pave the way for new ideas and innovations ... -
Interferon-alpha-induced cognitive and affective impairments : contributions of prefrontal cortex and hippocampal formation
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2009)Interferon-alpha (IFN-a) is a potent antiviral agent useful in the treatment of many malignancies, but most widely used in the treatment of Hepatitis C. However, sinister adverse events appear as a consequence of ... -
Social cognition in borderline personality disorder : an MRI investigation
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2013)There is increasing evidence for subtle changes in brain morphology and function in patients with borderline personality disorder (BPD). The four study arms in this thesis seek to investigate the differences in personality, ... -
The neural basis of reward processing in Autism Spectrum Disorder : brain function, structure and connectivity
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2013)Autism spectrum disorder (ASD) is a pervasive developmental disorder defined by impairments in reciprocal social interaction and communication, as well as stereotyped behaviour and repetitive interests (Lord et al., 2011). ... -
Investigation of S100B gene as a risk factor for biopolar disorder and schizophrenia
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2012)Calcium-binding protein S100B has been implicated in the pathology of bipolar affective disorder (BPAD) and schizophrenia (SZP). S100B protein levels are elevated in serum of patients with both disorders compared to controls. ... -
Investigation of putative candidate genes involved in the pathogenesis of Schizophrenia using a large Irish case-control sample
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2008)This research thesis involved a candidate gene search for schizophrenia in the Irish population. It sought to identify candidate genes based on positional and functional information contained in previously published material. ... -
The effect of catecholaminergic genes on executive functions : a behavioural and fMRI study
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2009)This thesis describes a study in two parts aimed at elucidating genetic links to executive functions and their neurological correlates. The catecholamines (in particular dopamine and noradrenaline) are known to be heavily ... -
Mental disorders in the community dwelling elderly
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2000)The elderly population is increasing both in numbers and as a proportion of the overall population. Mental disorders are common among the elderly. Most older people with mental disorders live in the community and attend ... -
Characterising schizophrenia candidate susceptibility genes using intermediate phenotypes
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2008)This thesis describes the use of intermediate phenotypes as a method for understanding, at a behavioural level, the functional significance of candidate susceptibility genes for schizophrenia. The historical context for ... -
A molecular genetic investigation of schizophrenia in an Irish study population
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2006)Schizophrenia (OMIM 181500) is a complex genetic disorder, which affects ~1% of the population, and typically presents in early adulthood with abnormalities of perception (psychosis), cognition, information processing and ... -
A candidate gene search for autism
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2006)This research involved a candidate gene search for autism in the Irish population. It sought to identify candidate genes based on information from linkage studies, reports of chromosomal abnormalities, animal studies and ...
