Psychiatry (Scholarly Publications): Recent submissions
Now showing items 221-240 of 363
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No evidence that runs of homozygosity are associated with schizophrenia in an Irish genome-wide association dataset
(2014)Runs of homozygosity (ROH), regions of the genome containing many consecutive homozygous SNPs, may represent two copies of a haplotype inherited from a common ancestor. A rare variant on this haplotype could thus be present ... -
Common variant at 16p11.2 conferring risk of psychosis
(2012)Epidemiological and genetic data support the notion that schizophrenia and bipolar disorder share genetic risk factors. In our previous genome-wide association study, meta-analysis and follow-up (totaling as many as 18?206 ... -
Identification of common variants associated with human hippocampal and intracranial volumes
(2012)Identifying genetic variants influencing human brain structures may reveal new biological mechanisms underlying cognition and neuropsychiatric illness. The volume of the hippocampus is a biomarker of incipient Alzheimer's ... -
Gene-ontology enrichment analysis in two independent family-based samples highlights biologically plausible processes for autism spectrum disorders.
(2011)Recent genome-wide association studies (GWAS) have implicated a range of genes from discrete biological pathways in the aetiology of autism. However, despite the strong influence of genetic factors, association studies ... -
Category fluency, latent semantic analysis and schizophrenia: a candidate gene approach
(2014)Background Category fluency is a widely used task that relies on multiple neurocognitive processes and is a sensitive assay of cortical dysfunction, including in schizophrenia. The test requires naming of as many words ... -
Effects of MIR137 on fronto-amygdala functional connectivity.
(2014)MIR137 is implicated in brain development and encodes a microRNA that regulates neuronal maturation and adult neurogenesis. Recently, a common genetic variant within MIR137 showed genome wide evidence of association with ... -
Epigenetics and depression: return of the repressed
(2014)Introduction: Epigenetics has recently emerged as a potential mechanism by which adverse environmental stimuli can result in persistent changes in gene expression. Epigenetic mechanisms function alongside the DNA sequence ... -
Use of codeine-containing medicines by Irish psychiatric in-patients before and after regulatory limitations on their supply.
(2013)Background. In recent years, concerns have been highlighted in several jurisdictions, including Ireland, regarding abuse of over-the-counter codeine-containing medicines. On the 1st of August 2010, national regulatory ... -
CSF Biomarkers and Incipient Alzheimer Disease in Patients With Mild Cognitive Impairment
(2009-07-22)Context Small single-center studies have shown that cerebrospinal fluid (CSF) biomarkers may be useful to identify incipient Alzheimer disease (AD) in patients with mild cognitive impairment (MCI), but large-scale multicenter ... -
Functional impact of global rare copy number variation in autism spectrum disorders
(2010)The autism spectrum disorders (ASDs) are a group of conditions characterized by impairments in reciprocal social interaction and communication, and the presence of restricted and repetitive behaviours(1). Individuals with ... -
Rare chromosomal deletions and duplications increase risk of schizophrenia.
(2008)Schizophrenia is a severe mental disorder marked by hallucinations, delusions, cognitive deficits and apathy, with a heritability estimated at 73-90% (ref. 1). Inheritance patterns are complex, and the number and type of ... -
Network-assisted investigation of combined causal signals from genome-wide association studies in schizophrenia.
(2012)With the recent success of genome-wide association studies (GWAS), a wealth of association data has been accomplished for more than 200 complex diseases/traits, proposing a strong demand for data integration and interpretation. ... -
Genome-wide association study implicates HLA-C*01:02 as a risk factor at the major histocompatibility complex locus in schizophrenia.
(2012)Background? We performed a genome-wide association study (GWAS) to identify common risk variants for schizophrenia. Methods? The discovery scan included 1606 patients and 1794 controls from Ireland, using 6,212,339 ... -
Investigation of the genetic association between quantitative measures of psychosis and schizophrenia: a polygenic risk score analysis.
(2012)The presence of subclinical levels of psychosis in the general population may imply that schizophrenia is the extreme expression of more or less continuously distributed traits in the population. In a previous study, we ... -
Social dysfunction in schizophrenia: An investigation of the GAF scale's sensitivity to deficits in social cognition.
(2013)BACKGROUND: Schizophrenia is accompanied by significant impairment in psychosocial functioning, which is only partially explained by clinical symptom severity. Recently, these impairments have been strongly associated ... -
Conditional analysis identifies three novel major histocompatibility complex loci associated with psoriasis.
(2012)Psoriasis is a common, chronic, inflammatory skin disorder. A number of genetic loci have been shown to confer risk for psoriasis. Collectively, these offer an integrated model for the inherited basis for susceptibility ... -
Common variants at 12q14 and 12q24 are associated with hippocampal volume.
(2012)Aging is associated with reductions in hippocampal volume (HV) that are accelerated by Alzheimer?s disease and vascular risk factors. Our genome-wide association study of dementia- free persons (n=9,232) identified 46 ... -
Runs of homozygosity implicate autozygosity as a schizophrenia risk factor.
(2012)Autozygosity occurs when two chromosomal segments that are identical from a common ancestor are inherited from each parent. This occurs at high rates in the offspring of mates who are closely related (inbreeding), but ... -
Using genome-wide complex trait analysis to quantify 'missing heritability' in Parkinson's disease.
(2012)Genome-wide association studies (GWASs) have been successful at identifying single-nucleotide polymorphisms (SNPs) highly associated with common traits; however, a great deal of the heritable variation associated with ...
