Psychiatry (Scholarly Publications): Recent submissions
Now showing items 241-260 of 363
-
Genome-wide association study identifies a variant in HDAC9 associated with large vessel ischemic stroke.
(2012)Genetic factors have been implicated in stroke risk but few replicated associations have been reported. We conducted a genome-wide association study (GWAS) in ischemic stroke and its subtypes in 3,548 cases and 5,972 ... -
Duplications of the neuropeptide receptor gene VIPR2 confer significant risk for schizophrenia.
(2011)Rare copy number variants (CNVs) play a prominent role in the etiology of schizophrenia and other neuropsychiatric disorders 1 . Substantial risk for schizophrenia is conferred by large (>500 kb) CNVs at several loci, ... -
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
(2011)Multiple sclerosis (OMIM 126200) is a common disease of the central nervous system in which the interplay between inflammatory and neurodegenerative processes typically results in intermittent neurological disturbance ... -
Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes
(2011)Metformin is the most commonly used pharmacological therapy for type 2 diabetes. We carried out a GWA study on glycaemic response to metformin in 1024 Scottish patients with type 2 diabetes. Replication was in two cohorts ... -
Genome-wide association study identifies five new schizophrenia loci.
(2011)We examined the role of common genetic variation in schizophrenia in a genome-wide association study of substantial size: a stage 1 discovery sample of 21,856 individuals of European ancestry and a stage 2 replication ... -
Failure to validate association between 12p13 variants and ischaemic stroke
(2010)We performed a genome-wide association study (GWAS) in 1705 Parkinson's disease (PD) UK patients and 5175 UK controls, the largest sample size so far for a PD GWAS. Replication was attempted in an additional cohort of 1039 ... -
Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region.
(2009)Ulcerative colitis (UC) is a common form of inflammatory bowel disease with a complex aetiology. As part of the Wellcome Trust Case Control Consortium 2, we performed a genome- wide association scan for UC in 2361 cases ... -
Analysis of 10 independent samples provides evidence for association between schizophrenia and a SNP flanking fibroblast growth factor receptor 2.
(2009)We and others have previously reported linkage to schizophrenia on chromosome 10q25-q26 but, to date, a susceptibility gene in the region has not been identified. We examined data from 3606 SNPs mapping to 10q25-q26 that ... -
A "Candidate-Interactome" Aggregate Analysis of Genome-Wide Association Data in Multiple Sclerosis
(2013)Though difficult, the study of gene-environment interactions in multifactorial diseases is crucial for interpreting the relevance of non-heritable factors and prevents from overlooking genetic associations with small but ... -
Development of Strategies for SNP Detection in RNA-Seq Data: Application to Lymphoblastoid Cell Lines and Evaluation Using 1000 Genomes Data.
(2013)Next-generation RNA sequencing (RNA-seq) maps and analyzes transcriptomes and generates data on sequence variation in expressed genes. There are few reported studies on analysis strategies to maximize the yield of quality ... -
Synergistic Effect between Maternal Infection and Adolescent Cannabinoid Exposure on Serotonin 5HT1A Receptor Binding in the Hippocampus: Testing the "Two Hit" Hypothesis for the Development of Schizophrenia,
(2012)Infections during pregnancy and adolescent cannabis use have both been identified as environmental risk factors for schizophrenia. We combined these factors in an animal model and looked at their effects, alone and in ... -
DUNDRUM-D: Developmental Understanding of Drug Misuse & Dependence (Short version)
(Central Mental Hospital, National Forensic Mental Health Service, 2012)This is the short version of the Developmental Understanding of Drug Misuse and Dependence DUNDRUM-D. DUNDRUM-D is an instrument which has grown out of the series of prison psychiatric morbidity studies carried out by ... -
DUNDRUM-D: Developmental Understanding of Drug Misuse & Dependence
(2012)Developmental Understanding of Drug Misuse and Dependence DUNDRUM-D This instrument has grown out of the series of prison psychiatric morbidity studies carried out by the National Forensic Mental Health Service in the ... -
A comparison of brief pulse and ultrabrief pulse electroconvulsive stimulation on rodent brain and behaviour
(2012)Brief pulse electroconvulsive therapy (BP ECT; pulse width 0.5-1.5 msec) is a very effective treatment for severe depression but is associated with cognitive side-effects. It has been proposed that ultrabrief pulse (UBP; ... -
Mental Illness in Irish Prisoners
(National Forensic Mental Health Service, Dundrum, Dublin 14, Ireland, 2004-12)This is the first systematic and representative survey of psychiatric morbidity in the Irish Prison population, using standardised research diagnostic methods. Five samples have been compiled, including 7% of all men ... -
How does the brain deal with cumulative stress? A review with focus on developmental stress, HPA axis function and hippocampal structure in humans
(2012)There is evidence that excessive stress exposure of the brain, mediated through the neurotoxic effects of cortisol and possibly neuroinflammation, causes damage to brain structure and function: the glucocorticoid cascade ... -
Neural correlates of treatment outcome in major depression.
(2011)There is a need to identify clinically useful biomarkers in major depressive disorder (MDD). In this context the functional connectivity of the orbitofrontal cortex (OFC) to other areas of the affect regulation circuit is ... -
Functional magnetic resonance imaging as a dynamic candidate biomarker for Alzheimer's disease.
(Elsevier, 2011)During the last two decades, imaging of neural activation has become an invaluable tool for assessing the functional organization of the human brain in vivo. Due to its widespread application in neuroscience, functional ... -
The NOS1 variant rs6490121 is associated with variation in prefrontal function and gray matter density in healthy individuals
(Elsevier, 2012)A common polymorphism within the nitric oxide sythanse-1 (NOS1) gene (rs6490121), initially identified as risk variant for schizophrenia, has been associated with variation in working memory and IQ. Here we investigated ... -
An X11[alpha]/FSBP complex represses transcription of the GSK3[beta] gene promoter.
(2010)X11? is a neuronal adaptor protein that interacts with the amyloid precursor protein (APP) via a centrally located phosphotyrosine binding (PTB) domain to inhibit production of A? peptide that is deposited in Alzheimer's ...
