Psychiatry (Scholarly Publications): Recent submissions
Now showing items 301-320 of 363
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Electroconvulsive therapy, capacity and the law in Ireland.
(Irish Institute of Psychological Medicine, 2009)The Mental Health Act (MHA) 2001 has major implications for treating patients with electroconvulsive therapy (ECT), especially as those referred for treatment are among the most severely ill and often lose capacity. Under ... -
Early Visual Processing Deficits in Dysbindin-Associated Schizophrenia
(2008)Background: Variation at the dysbindin gene (DTNBP1) has been associated with increased risk for schizophrenia in numerous independent samples and recently with deficits in general and domain-specific cognitive processing. ... -
Microstructural Correlates of Resilience against Major Depressive Disorder: Epigenetic Mechanisms?
(2010)Mental disorders are a major cause of long-term disability and are a direct cause of mortality, with approximately 800.000 individuals dying from suicide every year worldwide ? a high proportion of them related to major ... -
Molecular pathways involved in neuronal cell adhesion and membrane scaffolding contribute to schizophrenia and bipolar disorder susceptibility.
(2011)Susceptibility to schizophrenia and bipolar disorder may involve a substantial, shared contribution from thousands of common genetic variants each of small effect. Identifying if risk variants map to specific molecular ... -
The neuronal adaptor protein X11alpha interacts with the copper chaperone for SOD1 and regulates SOD1 activity.
(2001)The neuronal adaptor protein X11a participates in the formation of multiprotein complexes and intracellular trafficking. It contains a series of discrete protein-protein interaction domains including two contiguous ... -
Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region.
(Nature Publishing Group, 2009-11-15)Ulcerative colitis is a common form of inflammatory bowel disease with a complex etiology. As part of the Wellcome Trust Case Control Consortium 2, we performed a genome-wide association scan for ulcerative colitis in 2,361 ... -
Clinical symptomatology and the psychosis risk gene, ZNF804A
(2010)The single nucleotide polymorphism (SNP) rs1344706, mapping to the gene ZNF804A, has been implicated in schizophrenia susceptibility ([O'Donovan et al., 2008], [International Schizophrenia Consortium, 2009], [Stefansson ... -
Multicentre variability of MRI-based medial temporal lobe volumetry in Alzheimer's disease
(Elsevier, 2010)Magnetic resonance imaging (MRI)-based volumetry of medial temporal lobe regions is among the best established biomarker candidates of Alzheimer's disease (AD) to date. This study assessed the effect of multicentre variability ... -
Influence of NOS1 on verbal intelligence and working memory in both patients with schizophrenia and healthy control subjects.
(2009)Background: Human and animal studies have implicated the gene NOS1 in both cognition and schizophrenia susceptibility. Objectives: To investigate whether a potential schizophrenia risk SNP (rs6490121) identified in a recent ... -
The Imperative for Disease Modifying Treatments in Alzheimer s Disease
(Medical Association of Ireland, 2009)It is estimated that there are currently as many as 38,000 people with dementia in Ireland and that this figure may exceed 70,000 by 2026.1 Indeed the prevalence of dementia is rising worldwide and it is not surprising ... -
The Dundrum Toolkit. Dangerousness, Understanding, Recovery and Urgency Manual (The Dundrum Quartet). Four Structured Professional Judgement Instruments for Admission Triage, Urgency, Treatment Completion and Recovery Assessments
(Trinity College Dublin, 2010)The DUNDRUM QUARTET: This handbook describes a suite of four structured professional judgement instruments. These structured professional judgement instruments are intended to provide a validated and transparent means ... -
Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease.
(2009)We undertook a two-stage genome-wide association study (GWAS) of Alzheimer's disease (AD) involving over 16,000 individuals, the most powerful AD GWAS to date. In stage 1 (3,941 cases and 7,848 controls), we replicated the ... -
Evidence that genetic variation in the oxytocin receptor (OXTR) gene influences social cognition in ADHD
(2010)Some children with ADHD also have social and communication difficulties similar to those seen in children with autistic spectrum disorders and this may be due to shared genetic liability. As the oxytocin receptor (OXTR) ... -
Amyotrophic lateral sclerosis mutant vesicle-associated membrane protein-associated protein-B transgenic mice develop TAR-DNA-binding protein-43 pathology.
(2010)Cytoplasmic ubiquitin-positive inclusions containing TAR-DNA-binding protein-43 (TDP-43) within motor neurons are the hallmark pathology of sporadic amyotrophic lateral sclerosis (ALS). TDP-43 is a nuclear protein and the ... -
Expression of the Neuronal Adaptor Protein X11alpha Protects Against Memory Dysfunction in a Transgenic Mouse Model of Alzheimer's Disease
(2010)X11? is a neuronal-specific adaptor protein that binds to the amyloid-? protein precursor (A?PP). Overexpression of X11? reduces A? production but whether X11? also protects against A?-related memory dysfunction is not ... -
The Wellcome trust UK-Irish bipolar affective disorder sibling-pair genome screen: first stage report
(Nature Publishing Group, 2002)We have completed the first stage of a two-stage genome wide screen designed to identify chromosomal regions that may harbour susceptibility genes for bipolar affective disorder. The first stage screening sample included ... -
Evidence that variation at the serotonin transporter gene influences susceptibility to attention deficit hyperactivity disorder (ADHD): analysis and pooled analysis.
(2002)Reduced central serotonergic activity has been implicated in poor impulse regulation and aggressive behaviour in animals, adults and also young children.1,2 Two recently published studies have implicated variation at a ... -
Serotonergic System and Attention Deficit Hyperactivity Disorder (ADHD): a potential susceptibility locus at the 5-HT1B receptor gene in 270 Trios from a multi-center sample
(2002)Attention deficit hyperactivity disorder (ADHD) is a highly heritable and heterogeneous disorder, which usually becomes apparent during the first few years of childhood. Imbalance in dopamine neurotransmission has been ... -
Dopa decarboxylase gene polymorphisms and attention deficit hyperactivity disorder (ADHD): no evidence for association in the Irish population
(2001)Dopa decarboxylase (DDC) is an enzyme which catalyses the decarboxylation of both dopa to dopamine and L-5 hydroxytryptophan to serotonin. Both catecholamines are major neurotransmitters of the mammalian nervous system. ... -
Cigarette smoking and psychotic symptoms in bipolar affective disorder
(The Royal College of Psychiatrists, 2001)Background An association exists between smoking and schizophrenia, independent of other factors and related to psychotic symptomatology. Aims To determine whether smoking is associated with psychosis in bipolar affective ...
