Psychiatry (Scholarly Publications): Recent submissions
Now showing items 321-340 of 363
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Lack of gender effect on familial schizophrenia. A Brazilian study.
(Arquivos de Neuro Psiquiatria / Academia Brasileira de Neurologia - ABNEURO, 2000)Estudos epidemiologicos em esquizofrenia estabeleceram que a idade de inicio para o genero masculino precede em alguns anos aquela para o feminino. No entanto, tal efeito de genero n?o vem sendo observado para os casos ... -
Synaptosomal-Associated Protein 25 (SNAP-25) and Attention Deficit Hyperactivity Disorder (ADHD): Evidence of linkage and Association in the Irish Population.
(2002)Several lines of evidence have suggested that ADHD is a polygenic disorder produced by the interaction of several genes each of a minor effect. Synaptosomal-associated protein 25 (SNAP-25) is a presynaptic plasma membrane ... -
Dopaminergic system genes in ADHD: toward a biological hypothesis
(2002)Converging evidence has implicated abnormalities of dopamine neurotransmission to the pathology of attention deficit hyperactivity disorder (ADHD). Several genetic association studies have been published, but so far, no ... -
Genome scan meta-analysis of schizophrenia and bipolar disorder, part III: Bipolar disorder
(2003)Genome scans of bipolar disorder (BPD) have not produced consistent evidence for linkage. The rank-based genome scan meta-analysis (GSMA) method was applied to 18 BPD genome scan data sets in an effort to identify regions ... -
Joint Analysis of the DRD5 Marker Concludes Association with Attention-Deficit/Hyperactivity Disorder Confined to the Predominantly Inattentive and Combined Subtypes
(2004)Attention-deficit/hyperactivity disorder (ADHD) is a highly heritable, heterogeneous disorder of early onset, consisting of a triad of symptoms: inattention, hyperactivity, and impulsivity. The disorder has a significant ... -
The Depression Network (DeNT) Study: Methodology and Sociodemographic characteristics of the first 470 affected sibling pairs from a large multi-site linkage genetics study
(BMC, 2004)Background: The Depression Network Study (DeNt) is a multicentre study designed to identify genes and/or loci linked to and/or associated with susceptibility to unipolar depression in Caucasian families. This study ... -
Is 'Clinical' insight the same as 'Cognitive' insight in schizophrenia?
(Cambridge University Press, 2009)Poor insight is associated with impaired cognitive function in psychosis. Whether poor clinical insight overlaps with other aspects of self-awareness in schizophrenia, such as cognitive self-awareness, is unclear. We ... -
Whole genome linkage scan of recurrent depressive disorder from the depression network study
(Oxford University Press, 2005)Genome-wide linkage analysis was carried out in a sample of 497 sib pairs concordant for recurrent major depressive disorder (MDD). There was suggestive evidence for linkage on chromosome 1p36 where the LOD score for ... -
Automated detection of brain atrophy patterns based on MRI for the prediction of Alzheimer's disease
(2010)Subjects with mild cognitive impairment (MCI) have an increased risk to develop Alzheimer?s disease (AD). Voxel-based MRI studies have demonstrated that widely distributed cortical and subcortical brain areas show atrophic ... -
Association between dopamine transporter (DAT1)genotype, left sided inattention, and an enhanced response to methylphenidate in attention deficit hyperactivity disorder
(2005)A polymorphism of the dopamine transporter gene (DAT1, 10-repeat) is associated with attention-deficit hyperactivity disorder (ADHD) and has been linked to an enhanced response to methylphenidate (MPH). One aspect of the ... -
Combined Analysis from Eleven Linkage Studies of Bipolar Disorder Provides Strong Evidence of Susceptibility Loci on Chromosomes 6q and 8q
(Elsevier, 2005)Several independent studies and meta-analyses aimed at identifying genomic regions linked to bipolar disorder (BP) have failed to find clear and consistent evidence of linkage regions. Our hypothesis is that combining the ... -
Confirmation of association between autism and the mitochondrial aspartate/glutamate carrier SLC25A12 gene on chromosome 2q31
(American Psychiatric Association, 2005)OBJECTIVE: Autism is a neurodevelopmental disorder with childhood onset and a known major genetic component. A recent study identified a highly significant association between autism and a two-single-nucleotide-polymorphism ... -
Preferential Transmission of Paternal Alleles at Risk Genes in Attention Deficit/Hyperactivity Disorder
(2005)Family, twin, and adoption studies have demonstrated a significant genetic contribution to the etiology of attention-deficit/hyperactivity disorder (ADHD). Pharmacological, neuroimaging, and animal-model findings suggest ... -
Spatial attentional bias as a marker of genetic risk, symptom severity and stimulant response in ADHD.
(2007)Attention-deficit hyperactivity disorder (ADHD) is a heritable childhood onset disorder that is marked by variability at multiple levels including clinical presentation, cognitive profile, and response to stimulant ... -
Gene-environment interplay in attention-deficit hyperactivity disorder and the importance of a develomental perspective
(The Royal College of Psychiatrists, 2007)Attention-deficit hyperactivity disorder (ADHD) varies in its clinical presentation and course. Susceptibility gene variants for ADHD and associated antisocial behaviour are being identified with emerging evidence of ... -
Dissociation in performance of children with ADHD and high-functioning autism on a task of sustained attention.
(Elsevier, 2007)Attention deficit hyperactivity disorder (ADHD) and autism are two neurodevelopmental disorders associated with prominent executive dysfunction, which may be underpinned by disruption within fronto-striatal and fronto-parietal ... -
Recurrent Rearrangements of Chromosome 1q21.1 and Variable Pediatric Phenotypes
(Massachusetts Medical Society, 2008)Background Duplications and deletions in the human genome can cause disease or predispose persons to disease. Advances in technologies to detect these changes allow for the routine identification of submicroscopic imbalances ... -
Psychiatric Genetics in the post genome age
(The Royal College of Psychiatrists, 2003)Less than 50 years after publication of the structure of DNA, we possess a working draft of the human genome and expect a completed draft listing all genes and their location by 2003 (International Human Genome Sequencing ... -
Bipolar affective puerperal psychosis- genome-wide significant evidence for linkage to chromosome 16.
(American Psychiatric Publishing, 2007)OBJECTIVE: Vulnerability to the triggering of bipolar episodes by childbirth aggregates in families and may define a genetically relevant subtype of bipolar disorder. The authors conducted a search by systematic whole ... -
Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder.
(Nature Publishing Group, 2008)To identify susceptibility loci for bipolar disorder, we tested 1.8 million variants in 4,387 cases and 6,209 controls and identified a region of strong association (rs10994336, P = 9.1 10-9) in ANK3 (ankyrin G). We also ...
