Browsing Microbiology (Theses and Dissertations) by Date of Publication
Now showing items 41-60 of 87
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Investigation of Plasmodium falciparum aminopeptidases and characterisation of the M17 leucine aminopeptidase
(Trinity College (Dublin, Ireland). Department of Microbiology, 2008)Plasmodium falciparum spends part of its life cycle residing in human erythrocytes, during which time it digests much of the host cell haemoglobin to provide a source of amino acids for synthesis of its own proteins. The ... -
The Dps protein of Salmonella enterica serovar Typhimurium
(Trinity College (Dublin, Ireland). Department of Microbiology, 2008)As a nucleoid-associated protein, Dps has long been thought to influence gene expression at a global level. In this study the role of Dps in genetic regulation in Salmonella enterica serovar Typhimurium was investigated. ... -
Development of SFV-based plasmid electroporation for use in tumour treatment and vaccine delivery
(Trinity College (Dublin, Ireland). Department of Microbiology, 2008)Electroporation is the delivery of short and intense electric pulses into living cells (either in tissue or suspension), which results in a transient and reversible increase in permeability of the cell transmembrane. This ... -
Semliki Forest virus based gene therapy of rat glioma
(Trinity College (Dublin, Ireland). Department of Microbiology, 2009)Glioblastoma multiforme (GBM) is an invariably fatal neoplastic lesion of the CNS. Despite advances in the treatment of cancer in the recent years, the prognosis of GBM has changed little and patients who undergo surgical ... -
Molecular genetic typing characteristics of human and animal isolates of Staphylococcus aureus
(Trinity College (Dublin, Ireland). Department of Microbiology, 2009)Staphylococcus aureus is a commensal and an opportunistic pathogen of both man and animals. It is capable of causing a broad spectrum of diseases, ranging in severity from superficial skin complaints such as boils and ... -
Biasing switching outcomes in the Escherichia coli fim site-specific recombination system through DNA supercoiling and nucleoid-associated proteins
(Trinity College (Dublin, Ireland). Department of Microbiology, 2010)Type 1 fimbriae are typically expressed in nutrient poor environments and facilitate colonization through attachment when the bacterium can no longer support a motile lifestyle that demands a high metabolic flux. They play ... -
Investigation of herbicide-based compounds as novel anti-malarial agents
(Trinity College (Dublin, Ireland). Department of Microbiology, 2010)Plasmodium falciparum causes the most severe form of malaria in humans. Currently, no effective vaccine exists and the emergence of widespread drug resistance in the parasite has further increased the necessity for novel ... -
Construction and development of simliki forest virus vectors for transient gene therapy of model tumours in mice
(Trinity College (Dublin, Ireland). Department of Microbiology, 2010)Cancer is a molecular and genetic disease that results from multiple alterations of genes, including proto-oncogenes and tumour-suppressor genes. Virotherapy is a branch of cancer gene therapy where oncolytic viruses are ... -
Fibronectin-binding protein B variation in straphylococcus aureus
(Trinity College (Dublin, Ireland). Department of Microbiology, 2010)The surface-expressed fibronectin-binding proteins FnBPA and FnBPB of Staphylococcus aureus mediate attachment to immobilised fibronectin, fibrinogen and elastin. These proteins are encoded by two closely linked but ... -
Studies of Streptococcus pneumoniae colonisation : role of capsule and induction of protective immunity
(Trinity College (Dublin, Ireland). Department of Microbiology, 2010)Streptococcus pneumoniae (the pneumococcus) is a major human pathogen responsible for an estimated 1.6 million deaths each year, most of which are of young children in the developing world. Current pneumococcal vaccines ... -
The identification of novel peptides using phage display with the potential for use in breast cancer therapy
(Trinity College (Dublin, Ireland). Department of Microbiology, 2011)Breast cancer is a leading cause of cancer-related mortality in women. Current treatments for breast cancer include surgery, radiotherapy, chemotherapy and hormone therapy. The recent development of Herceptin has added a ... -
Biomass to biofuel : towards the bioengineering of Saccharomyces species for cellulose degradation
(Trinity College (Dublin, Ireland). Department of Microbiology, 2011)Cellulose is the most abundant polysaccharide on earth and therefore represents a major reservoir of sugar that could be potentially converted to alcohol and used as a fuel source. The filamentous fungus Trichoderma reesei ... -
Identification of factors involved in 3' end processing and transcription termination of histone mRNAs
(Trinity College (Dublin, Ireland). Department of Microbiology, 2011)The production of core histone mRNAs is tightly regulated during the cell cycle in all eukaryotic cells. Histone mRNAs accumulate during the S-phase and are subsequently degraded upon entry into G2-phase of the cell cycle. ... -
Identification and characterization of novel Plasmodium falciparum cyclophilins and their roles in the antimalarial actions of cyclosporin A
(Trinity College (Dublin, Ireland). Department of Microbiology, 2011)Malaria is a parasitic infection of immense global importance. The most common and severe form of the disease is caused by the blood-borne apicomplexan Plasmodium falcipanim. The lack of an effective vaccine coupled with ... -
Antimicrobial peptide preventing beer spoilage
(Trinity College (Dublin, Ireland). Department of Microbiology, 2012)Beer spoilage micro-organisms (BSMs) are a common threat to Master Brewers worldwide. Numerous studies have been carried out to date to overcome this problem, yet the most common preventative measure is the addition of ... -
The interaction of clumping factor B and iron-regulated surface determinant protein A of Staphylococcus aureus with the squamous epithelial cell envelope protein loricrin
(Trinity College (Dublin, Ireland). Department of Microbiology, 2013)Staphylococcus aureus permanently colonises the anterior nares of 20% of the human population while the remainder is colonised intermittently. Clumping factor B (ClfB) is a surface-expressed staphylococcal protein that ... -
Analysis of the function of the N1 subdomain of MSCRAMMs of Staphylococcus aureus
(Trinity College (Dublin, Ireland). Department of Microbiology, 2014)The Microbial Surface Component Recognising Adhesive Matrix Molecules (MSCRAMMs) family of cell wall-associated proteins have recently been reclassified based on structure-function analysis. Under this new regime the MSCRAMM ... -
Investigation of the transcriptional landscape and RNA biology of Salmonella Typhimurium plasmids
(Trinity College (Dublin, Ireland). Department of Microbiology, 2014) -
Investigating regulation of gene transcription by the Tup1-Ssn6 co-repressor complex in Saccharomyces cerevisiae
(Trinity College (Dublin, Ireland). Department of Microbiology, 2015)Transcriptional repression is an important part of gene regulation. In the budding yeast Saccharomyces cerevisiae the Tup1-Ssn6 corepressof complex is recruited to gene promoters to repress transcription in response to ... -
Biomass to biofuel : the engineering of Saccharomyces species for the co-fermentation of cellulose and xylose
(Trinity College (Dublin, Ireland). Department of Microbiology, 2015)Lignocellulose represents one of the most abundant biomass sources in the world. Its renewable and abundant nature makes it a prime target for use in bioethanol production. The efficient conversion of lignocellulosic biomass ...