Browsing Microbiology (Theses and Dissertations) by Title
Now showing items 75-87 of 87
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The cell biology of microtubule inhibition in Plasmodium falciparum
(Trinity College (Dublin, Ireland). Department of Microbiology, 2008)Malaria is among the most prevalent human infections worldwide and both the lack of a viable vaccine and the spread of resistance to commonly used drugs have limited the options for control of the parasite, especially ... -
The Dps protein of Salmonella enterica serovar Typhimurium
(Trinity College (Dublin, Ireland). Department of Microbiology, 2008)As a nucleoid-associated protein, Dps has long been thought to influence gene expression at a global level. In this study the role of Dps in genetic regulation in Salmonella enterica serovar Typhimurium was investigated. ... -
The genome of Plasmodium falciparum
(Trinity College (Dublin, Ireland). Department of Microbiology, 2007)The base distribution of the 14 nuclear chromsomes, of the plastid and the mitochondrion of the malarial parasite Plasmodium falciparum were studied. Isochores were discovered in the nuclear chromosomes and found to be ... -
The identification of novel peptides using phage display with the potential for use in breast cancer therapy
(Trinity College (Dublin, Ireland). Department of Microbiology, 2011)Breast cancer is a leading cause of cancer-related mortality in women. Current treatments for breast cancer include surgery, radiotherapy, chemotherapy and hormone therapy. The recent development of Herceptin has added a ... -
The interaction of clumping factor B and iron-regulated surface determinant protein A of Staphylococcus aureus with the squamous epithelial cell envelope protein loricrin
(Trinity College (Dublin, Ireland). Department of Microbiology, 2013)Staphylococcus aureus permanently colonises the anterior nares of 20% of the human population while the remainder is colonised intermittently. Clumping factor B (ClfB) is a surface-expressed staphylococcal protein that ... -
The transcriptional landscape and small RNAs in Acinetobacter baumannii AB5075 during antibiotic and environmental stress.
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Microbiology, 2024)Multi-drug resistant Acinetobacter baumannii is considered a major challenge because it causes a variety of serious infections. Studying these bacteria at the level of their genetic response could facilitate finding a way ... -
Tumour therapy using cytokine-expressing semliki forest virus vectors
(Trinity College (Dublin, Ireland). Department of Microbiology, 2005)Semliki Forest Virus (SFV) vector is a transient RNA based suicidal expression vector system and has been previously used as a potential anti-cancer agent. Recently, a new enhanced SFV vector has been developed, pSFV10-E. ... -
Understanding benzalkonium chloride tolerance and its implications in antibiotic resistance and other phenotypes in clinical isolates of Klebsiella pneumoniae
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Microbiology, 2024)In this study, clinical isolates of Klebsiella pneumoniae, a Gram-negative pathogen associated with hospital acquired infections, were tested for both phenotypic and genotypic changes following adaptation to the commonly ... -
Understanding the Role of Host Factors in the Modulation of Virulence Factors of Staphylococcus aureus.
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Microbiology, 2023)Staphylococcus aureus is adept at colonising and infecting the human host. Host factors are known to influence pathogen physiology and this thesis aimed to examine the effects of human bile and human plasmin on S. aureus. ... -
Understanding Tolerance to Biocides and its Consequences in Clinical Isolates of Klebsiella pneumoniae - How to Treat an ESKAPE Pathogen
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Microbiology, 2024)Biocides such as Triclosan, Benzalkonium Chloride, and Chlorhexidine have been used as disinfectants for many years, however the effects of their use and the subsequent selective pressures applied to microbial populations ... -
Unravelling a food derived bioactive peptide with dual functionality of antimicrobial and immunomodulatory properties
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Microbiology, 2020)In this thesis, a computational data mining and feature based approach to unravel the abundance of unexplored peptides from nature and to identify potent, novel antimicrobial peptides (AMPs) from phyto-proteins is proposed. ... -
Variations in silver stained nucleolar organiser regions(AgNORs) in normal, irradiated and neoplastic tissues
(Trinity College (Dublin, Ireland). Department of Microbiology, 2001)Nucleolar organiser regions (NORs) are loops of ribosomal DNA which contain the genes that transcribe to ribosomal RNA. They are situated on the short arm of the acrocentric human chromosomes 13, 14, 15, 21 and 22. Several ... -
Virulence gene regulation by nucleoid associated proteins in Salmonella typhimurium : a role for Fis in Salmonella pathogenicity island 2 gene regulation
(Trinity College (Dublin, Ireland). Department of Microbiology, 2004)Nucleoid associated proteins are involved in many diverse biological functions in S. typhimurium. In addition to their structural role within the genome they have been im plicated in transcriptional regulation of a variety ...