Browsing Microbiology (Theses and Dissertations) by Date of Publication
Now showing items 81-87 of 87
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Genetic and Molecular Studies of Virulence Factors of Staphylococcus aureus
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Microbiology, 2023) -
Investigating Tup1-Cyc8 complex function in Saccharomyces cerevisiae following the confirmation and characterization of a TUP1 conditional mutant
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Microbiology, 2023)The Tup1-Cyc8 complex is a well-defined corepressor complex found in S. cerevisiae. It is known to regulate close to 3% of all yeast genes and has orthologs reported in mammals. Its exact functioning is not well-understood. ... -
Distinct phenotypes and transcriptomes of tup1 and cyc8 mutants suggest novel roles for TUP1 and CYC8 in Saccharomyces cerevisiae
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Microbiology, 2023)The Tup1-Cyc8 (Ssn6) co-repressor complex is a regulator of gene transcription in the yeast Saccharomyces cerevisiae. This project provides insights into the distinct roles of Tup1p and Cyc8p in gene repression, identifies ... -
Investigating the potential to source novel postbiotics with anti-microbial or immune-modulatory activity from distillery waste
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Microbiology, 2024)The purpose of this project is to find a novel source for antimicrobial and immunomodulatory compounds. Here we investigate the antimicrobial and immunomodulatory potential of postbiotics sourced from whisky distillation. ... -
Understanding Tolerance to Biocides and its Consequences in Clinical Isolates of Klebsiella pneumoniae - How to Treat an ESKAPE Pathogen
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Microbiology, 2024)Biocides such as Triclosan, Benzalkonium Chloride, and Chlorhexidine have been used as disinfectants for many years, however the effects of their use and the subsequent selective pressures applied to microbial populations ... -
Understanding benzalkonium chloride tolerance and its implications in antibiotic resistance and other phenotypes in clinical isolates of Klebsiella pneumoniae
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Microbiology, 2024)In this study, clinical isolates of Klebsiella pneumoniae, a Gram-negative pathogen associated with hospital acquired infections, were tested for both phenotypic and genotypic changes following adaptation to the commonly ... -
The transcriptional landscape and small RNAs in Acinetobacter baumannii AB5075 during antibiotic and environmental stress.
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Microbiology, 2024)Multi-drug resistant Acinetobacter baumannii is considered a major challenge because it causes a variety of serious infections. Studying these bacteria at the level of their genetic response could facilitate finding a way ...