Microbiology (Theses and Dissertations): Recent submissions
Now showing items 81-95 of 95
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Analysis of the chloramphenicol resistance determinant of plasmid R26
(Trinity College (Dublin, Ireland). Department of Microbiology, 1985)The Inc P-1 plasmid, R2B carries an inducible chloramphenicol resistance determinant, cml. This specifies low level chloramphenicol resistance (30 μg/ml] in Escherichia coli. The mechanism does not involve drug detoxification ... -
Investigating the transcriptional regulation of small RNA expression in Salmonella enterica serovar Typhimurium
(Trinity College (Dublin, Ireland). Department of Microbiology, 2015)Salmonella enterica serovar Typhimurium (S. Typhimurium) is an important foodborne pathogen that causes self-limiting gastroenteritis, or more serious systemic infections in susceptible hosts. S. Typhimurium can infect a ... -
The identification of novel peptides using phage display with the potential for use in breast cancer therapy
(Trinity College (Dublin, Ireland). Department of Microbiology, 2011)Breast cancer is a leading cause of cancer-related mortality in women. Current treatments for breast cancer include surgery, radiotherapy, chemotherapy and hormone therapy. The recent development of Herceptin has added a ... -
The interaction of clumping factor B and iron-regulated surface determinant protein A of Staphylococcus aureus with the squamous epithelial cell envelope protein loricrin
(Trinity College (Dublin, Ireland). Department of Microbiology, 2013)Staphylococcus aureus permanently colonises the anterior nares of 20% of the human population while the remainder is colonised intermittently. Clumping factor B (ClfB) is a surface-expressed staphylococcal protein that ... -
Identification and characterization of novel Plasmodium falciparum cyclophilins and their roles in the antimalarial actions of cyclosporin A
(Trinity College (Dublin, Ireland). Department of Microbiology, 2011)Malaria is a parasitic infection of immense global importance. The most common and severe form of the disease is caused by the blood-borne apicomplexan Plasmodium falcipanim. The lack of an effective vaccine coupled with ... -
Antimicrobial peptide preventing beer spoilage
(Trinity College (Dublin, Ireland). Department of Microbiology, 2012)Beer spoilage micro-organisms (BSMs) are a common threat to Master Brewers worldwide. Numerous studies have been carried out to date to overcome this problem, yet the most common preventative measure is the addition of ... -
Construction and development of simliki forest virus vectors for transient gene therapy of model tumours in mice
(Trinity College (Dublin, Ireland). Department of Microbiology, 2010)Cancer is a molecular and genetic disease that results from multiple alterations of genes, including proto-oncogenes and tumour-suppressor genes. Virotherapy is a branch of cancer gene therapy where oncolytic viruses are ... -
Biomass to biofuel : towards the bioengineering of Saccharomyces species for cellulose degradation
(Trinity College (Dublin, Ireland). Department of Microbiology, 2011)Cellulose is the most abundant polysaccharide on earth and therefore represents a major reservoir of sugar that could be potentially converted to alcohol and used as a fuel source. The filamentous fungus Trichoderma reesei ... -
Fibronectin-binding protein B variation in straphylococcus aureus
(Trinity College (Dublin, Ireland). Department of Microbiology, 2010)The surface-expressed fibronectin-binding proteins FnBPA and FnBPB of Staphylococcus aureus mediate attachment to immobilised fibronectin, fibrinogen and elastin. These proteins are encoded by two closely linked but ... -
Identification of factors involved in 3' end processing and transcription termination of histone mRNAs
(Trinity College (Dublin, Ireland). Department of Microbiology, 2011)The production of core histone mRNAs is tightly regulated during the cell cycle in all eukaryotic cells. Histone mRNAs accumulate during the S-phase and are subsequently degraded upon entry into G2-phase of the cell cycle. ... -
Investigation of herbicide-based compounds as novel anti-malarial agents
(Trinity College (Dublin, Ireland). Department of Microbiology, 2010)Plasmodium falciparum causes the most severe form of malaria in humans. Currently, no effective vaccine exists and the emergence of widespread drug resistance in the parasite has further increased the necessity for novel ... -
Biasing switching outcomes in the Escherichia coli fim site-specific recombination system through DNA supercoiling and nucleoid-associated proteins
(Trinity College (Dublin, Ireland). Department of Microbiology, 2010)Type 1 fimbriae are typically expressed in nutrient poor environments and facilitate colonization through attachment when the bacterium can no longer support a motile lifestyle that demands a high metabolic flux. They play ... -
Studies of Streptococcus pneumoniae colonisation : role of capsule and induction of protective immunity
(Trinity College (Dublin, Ireland). Department of Microbiology, 2010)Streptococcus pneumoniae (the pneumococcus) is a major human pathogen responsible for an estimated 1.6 million deaths each year, most of which are of young children in the developing world. Current pneumococcal vaccines ... -
Epidemiology of Streptococcus agalactiae (Group B Streptococci) in Dublin Maternity Hospitals
(Trinity College (Dublin, Ireland). Department of Microbiology, 2002)Streptococcus agalactiae (Group B Streptococci) are Gram-positive encapsulated cocci distinguished from other streptococci by their narrower zones of P-haemolysis. Group B Streptococci (GBS) was first described as an ... -
Investigation of the transcriptional landscape and RNA biology of Salmonella Typhimurium plasmids
(Trinity College (Dublin, Ireland). Department of Microbiology, 2014)
