Clinical Medicine (Theses and Dissertations): Recent submissions
Now showing items 121-140 of 355
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NEURODEVELOPMENTAL OUTCOME FOR TWINS OF THE ESPRiT STUDY: THE NOTES STUDY
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2021)THE NOTES STUDY: ABSTRACT Objective: The objective of the NOTES Study was to study the effect of birthweight growth discordance (≥ 20%) on neurodevelopmental outcome and physical growth of monochorionic and dichorionic ... -
The clinical and neuroimaging profiles of primary lateral sclerosis: a longitudinal research study
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2021)Primary Lateral Sclerosis (PLS) is a progressive, idiopathic upper motor neuron (UMN) disease. Clinically, PLS is defined by the presence of spasticity and associated UMN signs without concurrent evidence of lower motor ... -
In-depth profiling of drug resistance to PI3K-mTOR inhibition and intra-tumour heterogeneity in NSCLC
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2021)Lung cancer has an overall 5-year survival rate of less than 15% and is the leading cause of cancer-related death worldwide. As such, it is crucial we develop new treatment strategies to overcome this formidable disease. ... -
Investigating the role of IL-36 cytokines in mediating angiogenesis and vascular permeability
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2021)Neovascular blinding conditions including age related macular degeneration and diabetic retinopathy are the most common causes of blindness in the elderly and working age populations respectively. Currently the best-in-class ... -
Defining the role of RORα in the functionality of distinct immune cell populations
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2021)The transcription factor Retinoic acid-related Orphan Receptor (ROR)-a has roles in metabolism, circadian rhythm and cellular development, such as Th17 cells and group 2 innate lymphoid cells (ILC2). The identification ... -
Ketamine for depression: Clinical use and media accounts
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2021)This thesis comprises two research studies, one of which is a clinical trial. Study 1: Pilot randomised controlled trial: Ketamine as an adjunctive therapy for major depression, the Karma-Dep Trial (NCT03256162). The ... -
Study of Macular Pigments in Glaucoma
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2021)The macula can be involved in the early stage of glaucoma, as evidenced by the presence of paracentral scotoma on visual field tests (Drance 1969) or thinning of the ganglion cell complex (GCC) layer on optical coherence ... -
Assessing the Efficacy and Safety of Bimodal Neuromodulation for the Management of Symptomatic Tinnitus
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2021)Tinnitus is defined as the perception of sound in the absence of an external auditory stimulus. It is a common symptom, affecting 5 30% of the general population, however only 1 3% of patients report the symptom to be ... -
Three-dimensional (3D) hepatic cell culture models to improve the clinical translation of nanobiomaterials (NBMs)
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2021)Despite the wide-reaching applications of nanoparticles that may be used for medical applications, i.e. nanobiomaterials or NBMs, in human health and medicine, their translation to the clinic is staggering slow, with a ... -
Eye Tracking Evaluations of Control Populations and Children with Focal Epilepsy
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2021)Eye tracking has emerged as a powerful tool in studying the eye movements of children. Previous eye tracking studies have not examined eye movements of children with focal epilepsy. The aim of this study was to develop a ... -
Human Neurodegeneration: A Spectral EEG and TMS based Approach in Amyotrophic Lateral Sclerosis
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2021)Amyotrophic lateral sclerosis (ALS) is defined by the neurodegeneration of upper and lower motor neurons of the corticospinal tract, resulting in progressive, terminal and incurable decline in movement, speech and swallowing ... -
The role of angiopoietins and their mediators in symptomatic small bowel angiodysplasia; identifying novel diagnostic and therapeutic targets in chronic anaemia and obscure gastrointestinal bleeding
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2021)Title : The role of angiopoietins and their mediators in symptomatic small bowel angiodysplasia; identifying novel diagnostic and therapeutic targets in chronic anaemia and obscure gastrointestinal bleeding. Author: Dr ... -
Development of an Objective Assessment of the Cognitive, Posturographic, and Electrophysiological Phenotype of the Fragile X Premutation, and analysis of their contribution to Postural Instability.
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2021)The Fragile X Premutation is a complex genetic anomaly which affects one in 260 females and 400 males and results in a broad range of symptoms and distinct conditions. The premutation phenotype involves cognitive and motor ... -
The implementation of a collaborative peer learning 2:1 model of practice placement education within dietetics pre-registration training in Ireland
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2021)The educational approach towards practice education in health-related disciplines has changed in recent years. The use of collaborative peer learning models of practice education has increased, associated with positive ... -
CO-MORBIDITIES OF HIDRADENITIS SUPPURATIVA
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2021)Hidradenitis suppurativa (HS), is a chronic inflammatory skin disorder which can have debilitating consequences if not managed appropriately from early on of its course of disease. Patients with this condition, also ... -
Characterisation of the role of IL-18 in neovascular AMD
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2021)Age-related macular degeneration is the leading cause of vision loss in the over 50’s in developed countries, accounting for 8.7% of all blindness worldwide. AMD is a progressive disease affecting the macula region of the ... -
Steroid resistance and Inflammatory bowel disease
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2021)Background: Steroid resistance remains a significant issue amongst IBD patients and mechanisms of resistance remain poorly understood. Endogenous Glucocorticoid metabolism may represent a key regulatory pathway in IBD. ... -
The altered immune microenvironment of human liver in metastatic disease
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2020)Globally, metastatic colon cancer is a significant disease with poor outcomes. Liver metastases are the leading cause of death and, despite maximal medical management, recurrent metastases are seen in up to 70% of patients ... -
On the Genotype and Phenotype of inherited retinal degenerations in an irish popultion
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2021)Aim: To elucidate the molecular diagnosis and perform deep phenotyping on patients with inherited retinal degenerations (IRDs) Methods: Patients were identified through self-referral or referral by an ophthalmologist ... -
Clinical clustering of eight orthostatic haemodynamic patterns in The Irish Longitudinal Study on Ageing (TILDA)
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2021)INTRODUCTION: Orthostatic hypotension (OH) can be assessed with non-invasive continuous beat-to-beat haemodynamic monitoring during active stand (AS) testing; this yields large volumes of data outside the scope of the ...
