Clinical Medicine (Theses and Dissertations): Recent submissions
Now showing items 101-120 of 355
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Advanced histology methods for biodistribution and safety screening of next generation nanobiomaterials
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2022)Over the past few decades nanobiomaterials (NBMs) have shown a promise in improving many areas of medicine such as diagnosis and treatment of diseases, with number of formulations currently approved for use by the regulators. ... -
Food Allergy among Irish Children: An Exploration of the Risk and Impact of Accidental Allergic Reactions
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2022)Introduction Food allergy (FA) now impacts almost 1 in 20 Irish children. These children are at risk of allergic reactions and anaphylaxis. Food is an integral part of all social activities, and thus children with FA ... -
Thrombin generation parameters, relationship with cerebral micro-embolic signal status, and a systematic review of the literature on platelet biomarkers in patients with symptomatic and asymptomatic carotid stenosis
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2022)Background:?Activation of platelets and the coagulation system are integrally involved in acute thrombus formation and distal thrombo-embolism. A better understanding of these complex thrombotic and haemostatic pathways ... -
Adaptive and Innate TH1 and TH17 Responses in Elderly Hospitalised Patients with Infection and Sepsis
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2021)Introduction: Sepsis carries a significant burden to health care. Almost a third of ICU patients have sepsis on admission or develop it during their admission. Sepsis carries a high mortality and affects all age groups ... -
Heart Rate Recovery Velocity in Cardiac Disease
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2022)Introduction Rate of recovery of heart rate between 10 and 20 seconds following orthostatic challenge (HRR10-20) is a risk factor for all-cause mortality. Furthermore, both cardiac rehabilitation and completeness of coronary ... -
Hungry for More: Measuring Metabolomic Responses in ANCA-Activated Monocytes
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2022)Immunometabolism examines the links between immune cell function and their metabolism. Advances in liquid chromatography mass spectrometry (LC-MS) technologies have uncovered unique insights into cellular metabolomics. ... -
Neuropsychological and Neuropsychiatric Endophenotypes in Amyotrophic Lateral Sclerosis
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2022)Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease, characterized by progressive muscle weakness and death, usually within 3-5 years from symptom onset. ALS is now recognized to be a multi-system ... -
Network Analysis in Motor Neuron Diseases: A Cortico-Muscular Coherence Study
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2022)Neurodegenerative conditions are associated with widespread changes in the motor networks. There is preliminary evidence from (f)MRI studies that the structural changes extend beyond the primary motor areas in cortical ... -
Detection of Neurovascular Compression in Trigeminal Neuralgia by high-resolution Magnetic Resonance Angiography
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2022)Trigeminal neuralgia (TGN, tic douloureux) refers to sudden severe paroxysms of severe lancinating pain on one side of the face involving one or more branches of the trigeminal nerve (CN V) which usually lasts a few seconds ... -
Immunometabolic responses of adult and umbilical cord macrophages to stimulation with Mycobacterium tuberculosis or Lipopolysaccharide
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2022)Tuberculosis (TB) has been the biggest infectious killer in the world in the last decade and young children are among the most vulnerable groups. Mycobacterium tuberculosis (Mtb), the bacteria that causes TB, is phagocytosed ... -
Cerebral Blood Flow and Cerebrovascular Reactivity Measurement using Arterial Spin Labeling MRI: Data from The Irish Longitudinal Study on Ageing (TILDA)
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2022)Background: Cerebral blood flow (CBF) and cerebrovascular reactivity (CVR) are important measures of cerebrovascular integrity and may provide an imaging biomarker for the early detection of diseases such as dementia and ... -
Does the future of epilepsy care lie in eHealth? An examination of attitudes and behaviours towards epilepsy self-management and eHealth from the perspectives of people with epilepsy, their carers and healthcare providers
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2022) -
HIP FRACTURES IN OLDER ADULTS AND TREATMENT WITH INTRAVENOUS ZOLEDRONIC ACID
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2022)Introduction: Osteoporotic hip fractures are common in older adults and are responsible for significant morbidity and mortality. Structured geriatric care for older adults with hip fracture is known to improve outcomes. A ... -
The Complexities of Antimicrobial Resistance in Acute Care: An Exploration of Key Actors and Factors Associated with Acute Care Antimicrobial Stewardship
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2022)Background Antimicrobial resistance (AMR) is an evolving global healthcare emergency, of which a significant driver is the use and overuse of antimicrobials. Antimicrobial stewardship (AMS) is a multi-component, multidisciplinary ... -
On dignity in inpatient psychiatric care
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2022)Dignity is an important concept in human rights legislation and medical ethics but is under-studied in psychiatric settings. It is a nuanced concept which is considered difficult to define, but nevertheless has a prominent ... -
Variation in clinical outcomes and immune consequences following two viral infections
Ageing is associated with increasing rates of ill-health. However, the burden of ill-health is not evenly distributed across ageing populations. The term biological age captures the consequences of ageing more effectively ... -
Recurrence of venous thromboembolism in patients with gynaecological cancer incidence, risk factors and impact on survival
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2022)Background: Gynaecological malignancy and surgery are independently associated with the highest risks of VTE. However, factors influencing the rate of recurrent VTE in patients with gynaecological malignancy are unknown. ... -
Implications of Cardiovascular Ageing for Cerebral Perfusion and Cognitive Performance
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2022)The aim of this thesis is to examine how common manifestations of cardiovascular ageing, Orthostatic Hypotension and Atrial Fibrillation, affect cerebral perfusion and cognitive function in Irish adults. Associations between ... -
Genetic Epidemiology and Cognitive Endophenotyping in Amyotrophic Lateral Sclerosis
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2021)Amyotrophic Lateral Sclerosis (ALS) is a progressive debilitating and ultimately fatal neurodegenerative disorder affecting both upper (UMN) and lower (LMN) motor neurons. While it has been long known to exist on a spectrum ... -
The Generation and Characterisation of Novel Mouse Models of Haemophilia A
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2021)Haemophilia A (HA) is a hereditary, X-linked recessive disease caused by mutations in the F8 gene, with the absence or deficiency in the coagulation factor, Factor VIII (FVIII), resulting in a bleeding diathesis. The ...
