Clinical Medicine (Theses and Dissertations): Recent submissions
Now showing items 161-180 of 355
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Vitamin D in the elderly and its relationship to inflammation and cognitive health
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2020)Background: There is a major shift in ageing demographics as individuals are experiencing increased longevity. This shift may be beneficial for the individual who will live into more advanced year than their ancestors. ... -
Investigation of the monogenic causes of chronic kidney disease
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2020)Chronic Kidney Disease (CKD) is a common chronic condition that affects 15 percent of adults in the Irish healthcare system. End stage kidney disease (ESKD) represents the final stage of CKD which culminates in the need ... -
INFLAMMATORY DENDRITIC CELLS IN THE HOST IMMUNE RESPONSE TO MYCOBACTERIA: THE ROLE OF CELLULAR METABOLISM
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2020)Mycobacterium tuberculosis (Mtb) causes an estimated 1.5 million deaths annually and BCG, the only available vaccine, is ineffective at preventing adult pulmonary TB. Inflammatory dendritic cells (DCs) play an essential ... -
Generation of sinapinic-acid containing extracts from irish rapeseed meal and characterisation of their bioactive properties for potential human health applications
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2020)Rapeseed is one of the world’s major oilseeds, and Europe is the largest producer. During the extraction of the oil, a low economic- value by-product, rapeseed meal, is produced. Rapeseed meal is ordinarily used as an ... -
Osteoporosis in adults with axial spondyloarthritis
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2020)Osteoporosis was the most prevalent comorbidity in individuals with axial spondyloarthropathy (axSpA) in a large multinational study. Ireland was not included in that study, so it was unknown if the profile of comorbidities ... -
Harmonic and superparamagnetic nanoparticles for biomedical imaging and diagnostic applications
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2020)Diagnosing certain diseases and tracking their progression requires the ability to 'see' into the body. This is typically achieved by taking advantage of intrinsic contrast in biological tissues (such as in X-ray or magnetic ... -
Assessing the potential of iron oxide nanoparticles to treat cancer through magnetic hyperthermia
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2020)5-year survival for pancreatic cancer is about 10% worldwide. A subset of this cancer, pancreatic ductal adenocarcinoma (PDAC), is estimated to become the second leading cause of cancer-related deaths in the US by 2030. ... -
Diabetes and Brain Health
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2020)Introduction: Type 2 diabetes mellitus (T2DM), one of the most common non-communicable diseases in the world, is linked to multi-organ complications. Such complications include cognitive impairment, dementia and depression. ... -
The Development and Application of a Novel Method for the Quantification of Prebeta-1 HDL in Plasma
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2019)Prebeta-1 HDL was one of the distinct molecular subspecies of HDL identified in the mid to late eighties . It is, now recognised as having a pivotal role in reverse cholesterol transport accounting for up to 90% of cholesterol ... -
Adaptive immune response in human Staphylococcus aureus bloodstream infection
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2019)Staphylococcus aureus bloodstream infection is a common and life-threatening condition. Treatment outcomes are poor, suboptimal clinical management is common, antimicrobial resistance continues to emerge, and there are few ... -
Alternative therapeutics for oesophageal cancer : novel toxic bile acid derivatives to induce apoptosis and siRNA library screen to identify genes that regulate cell shape
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2015)Oesophageal adenocarcinoma (OAC) is the sixth leading cause of cancer-related deaths worldwide, and has proven most challenging for surgeons as less than a third of patients are suitable for surgical resection due to ... -
Von Willebrand Factor, osteoprotegerin and protein C pathway in the pathogenesis of experimental cerebal malaria
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2015)Plasmodium falciparum malaria infection is associated with an early marked increase in plasma VWF levels, together with a pathological accumulation of hyperreactive ultra-large VWF (ULVWF) multimers. Given the established ... -
The inflammatory degenerative continuum of HIV related cognitive impairment
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2015)This thesis is the result of three years of research from January 2011 to December 2013 examining the role of cognition in HIV infection in an Irish specialist HIV service. This had not previously been examined in Ireland. ... -
Development of a nanowire-based assay for cancer biomarker detection in complex biological fluids
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2015)The cost of delivering healthcare continues to increase to phenomenal proportions with lung cancer, breast cancer, colorectal cancer and prostate cancer accounting for the majority of the economic burden associated with ... -
The role of novel IL-1 family members in Inflammatory Bowel Disease
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2015)Inflammatory Bowel Disease (IBD) is characterized by an imbalance between effector and regulatory arms of intestinal immunity. Emerging evidence suggests that IL-1 family members play a critical role in the maintenance of ... -
Exposure to reduced oxygenation following radiation exposure enhances the survival of prostate cancer cells in vitro: implications for radiation therapy delivery
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2010)Introduction: Hypoxia is a common feature of prostate tumours; hypoxic cells are more radioresistance compared to oxygenated cells. Hypoxic radioresistance has also been shown to be related to the duration of hypoxia prior ... -
Regulators of inflammation and innate immunity identified in oesophageal cancer cell viability through implementation of a druggable genome siRNA library screen
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2015)Inflammation initiated by gastroesophageal reflux disease (GORD) can lead to development of oesophageal adenocarcinoma (OAC), through a premalignant lesion, Barrett's oesophagus (BO). OAC has a 5-year survival of patients ... -
Mental Capacity for Medical Treatment Decisions in Medical and Surgical Hospital Inpatients in Ireland
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2019)Mental capacity both merits and requires substantial consideration and attention in present-day clinical practice, research and legislation. This is the first research study in the Republic of Ireland to evaluate the ... -
Characterisation of circulating tumour cells in men with advanced prostate cancer and correlation with numbers of circulating and tissue-based inflammatory cells
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2019)Many men with prostate cancer present with advanced stage disease, and in these men treatment is directed towards improved survival and quality-of-life rather than cure. Exercise therapies are recognised to have benefits ... -
Evaluation of diagnostic and treatment strategies for the management of Helicobacter pylori infection
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2019)Helicobacter pylori infection is responsible for chronic gastritis and the development of gastrointestinal disorders such as gastric or duodenal ulcers, gastric adenocarcinoma and mucosa-associated lymphoid tissue (MALT) ...
