Clinical Medicine (Theses and Dissertations): Recent submissions
Now showing items 181-200 of 355
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Motor and extra-motor involvement in amyotrophic lateral sclerosis
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2019)Amyotrophic Lateral Sclerosis (ALS) is primarily associated with pathology in the motor cortex and corticospinal tract. Based on clinical observations, it is increasingly recognised that extra-motor symptoms add to the ... -
Vitamin D deficiency: cognition, mortality and resource utilisation - prospective associations
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2019)Introduction: The association between Vitamin D and bone health has long been known. In recent times there has been increasing research into the effects of Vitamin D beyond this well-established link. Although there has ... -
Candidate role for TLR3 L412F in disease progression in Idiopathic Pulmonary Fibrosis (IPF) during bacterial and viral infection
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2019)In this thesis, we investigated the mechanisms by which TLR3 Leu412Phe (L412F) promotes disease progression in idiopathic pulmonary fibrosis (IPF) patients. IPF is a fatal interstitial lung disease of unknown aetiology and ... -
Synthesis and characterisation of aerosolised MIF inhitibitors for the treatment of respiratory disease
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2019)The main focus of this PhD thesis was to investigate the synthesis and characterisation of an aerosolised poly lactic-co-glycolic acid (PLGA) nanodrug delivery system for MIF enzyme inhibitors to modulate the physiological ... -
Polyunsaturated fatty acids, macrophages, and mediators of atherosclerosis: an in vitro investigation
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2004)Many cells are involved in the atherosclerotic process, but macrophages are present inevery phase of atherosclerosis and are heavily implicated as prime culprits in the molecular events that initiate, promote and complicate ... -
Nutritional and metabolic aspects of n-3 polyunsaturated fatty acids in health and disease
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2000)The health benefits of fish oils, rich in the n-3 polyunsaturated fatty acids (PUFA) eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are multi-faceted, spanning a number of human systems, including the cardiovascular, ... -
Folic acid fortification of flour : determination of the level that gives rise to unmetabolised folic acid in serum
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2001)To prevent neural tube defects the Food and Drug Administration (FDA) implemented mandatory folic acid fortification o f all flour milled in the USA at a level 140μg/100g. The Centers for Disease Control (CDC) have proposed ... -
The folate catabolic process, its implications for folate requirement in humans and its antibacterial drug function
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2001)The one-carbon cycle, of which folate is the predominant constituent, is a major carrier of one-carbon units for biochemical synthesis, and is thought to be the sole mechanism of methyl-group transfer. It is involved both ... -
Postprandial lipoprotein metabolism in diabetes
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2001)Cardiovascular disease is up to four times greater in patients with Type 2 diabetes compared with nonnoglycaemic individuals (Pyorala et al., 1987; Laakso and Lehto 1997). Abnormalities in lipid metabolism may, in part, ... -
The effects of conjugated linoleic acid on the human immune system
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2003)The cells of the immune system are sensitive to their exogenous environment. Indeed the amount and type of nutrients, including fatty acids, which this environment contains all influence subsequent immune cell functioning. ... -
Dietary and genetic factors affecting the cholesteryl ester transfer protein and lipoprotein metabolism
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2001)The cholesteryl ester transfer protein (CETP) plays an inherent role in the redistribution of neutral lipids between high density lipoproteins (HDL) and very low density lipoproteins (VLDL) and low density lipoproteins ... -
Tools and techniques for improving the assessment of exposure to food chemicals
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2000)Exposure assessments are an integral part of risk assessment and are essential for protecting consumer health and factilitating international trade. The aim of this thesis was to explore the potential usefulness of a number ... -
Characterization of proteins associated with the LFA-1 mediated cytoskeletal / signaling complex in locomotory T lymphocytes
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2005)LFA-1 plays a crucial role in all aspects of T cell locomotion in both immune physiological functions and pathological conditions. T cell locomotion is associated with translocation of protein kinase C isoenzymes β and δ ... -
The study of periodicity of eating & public health nutrition issues
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2001)This thesis set out to provide an objective understanding of periodicity of eating in a group of free- living adults, by determining the temporal pattern of nutrient intake during eating occasions throughout the day. A ... -
Development of a novel CD52 functionalised nanoparticle for the targeting of Chronic Lymphocytic Leukaemia
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2019)Nanomedicine has been recognised as a next-generation technology for the treatment and management of many disease states, including blood cancers. The term nanotechnology was first coined in 1974 and, is at the interface ... -
Dementia in the Acute General Hospital - Prevalence, Practices and Outcomes
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2019)Background The number of people living with dementia in Ireland is projected to increase exponentially in the coming decades. The international literature suggests, however, that the recognition of dementia is poor, ... -
Evaluation of Triple helix-forming Oligonucleotides as modulators of transcriptional initiation in erbB-2/HER-2-positive breast cancer : an anti-tumour approach
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2001)Research over the last several decades has made tremendous strides in the identification of the components of the human genome. Genetic information is expressed by translation of DNA into functional proteins through the ... -
The Tumour Necrosis Factor region in coeliac disease
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2003)Coeliac disease is a disease of the small intestine, characterised by villous atrophy and crypt hyperplasia. The disease can be defined as an intolerance in genetically susceptible individuals to certain storage proteins ... -
Methodological issues in risk assessment of human exposure to artificial sweeteners in food
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2001)The primary aim of this thesis is in estimating food chemical intakes with a specific interest in the area of intense sweeteners. To date all studies of intense sweeteners have been extremely detailed both in the estimate ... -
Nutritional aspects of trans unsaturated fatty acids
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2000)Dietary trans unsaturated fatty acids from hydrogenated vegetable and fish oils have been shown to raise plasma low density lipoprotein cholesterol and lower high density lipoprotein cholesterol levels at 10%, 6% and 3% ...
