Clinical Medicine (Theses and Dissertations): Recent submissions
Now showing items 341-355 of 355
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P-glycoprotein expression and function, relationship to plasma and intracellular drug concentrations, and the effects of HIV disease
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2007)P-glycoprotein Expression and Function: Peripheral blood lymphocytes (PBMCs) were isolated by Ficoll density gradient centrifugation, fixed and permeabilised. P- glycoprotein (P-gp) expression was quantified by flow cytometry ... -
Studies on the interaction of Helicobacter pylori with extracellular matrix proteins
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2008)Helicobacter pylori is a common human pathogen that persistently colonises the stomach of half the worlds population. The majority of people infected with H. pylori are asymptomatic, however, a proportion develop severe ... -
An investigation of T lymphocyte migration induced by CD44 activation
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2006)This thesis investigates the role of CD44 in signalling active migration in T lymphocytes. A number of murine studies have demonstrated that loss of CD44 expression by T lymphocytes resulted in a delayed migration to sites ... -
Sleeping with the head [up] of the bed tilted up: physiology & therapy
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2008)Orthostatic hypotension (OH) is common and affects people with increasing age and co-morbidity. It is associated with increased vascular risk, falls and dementia. While pharmacological and non-pharmacological treatments ... -
The transcriptomic analysis of low pH and bile acid induced gene expression in oesophageal cells
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2006)Oesophageal adenocarcinoma (OAC) commonly arises from the presence of a premalignant lesion known as Barrett’s Oesophagus (BO). Gastro-oesophageal reflux disease (GORD) has been identified in epidemiological studies as a ... -
Estimation of exposure to food packaging migrants in a sample of Irish children
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2007)Food packaging materials are not inert and transfer chemicals, known as migrants, into food. As the presence of chemicals in foods is a highly regulated area, food packaging migrants must undergo a risk assessment procedure ... -
Inherited variation in the xenobiotic response system in inflammatory bowel disease
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2007)The aim of this study was to further the understanding regarding the genetic background of Inflammatory Bowel Disease (IBD). IBD patients can be classified into two major phenotypes, Crohn’s disease (CD) and ulcerative ... -
A surgical delivery system for targeted cancer gene therapy : the potential therapeutic role of genetically modified microvascular free flaps in the management of primary tumours
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2009)Gene therapy has generated interest for the treatment of soft tissue malignancies. It offers the theoretical promise of delivering cytotoxic, immunomodulatory, or anti- angiogenic genes to produce proteins targeting tumour ... -
Post operative atrial fibrillation
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2006)Post operative atrial fibrillation is a common occurrence following all forms of cardiac surgery apart from heart transplantation. Coronary artery bypass is the commonest cardiac surgical procedure with more than 800,000 ... -
A study of food consumption patterns of children and adults in Ireland : implications for the development of food-based dietary guidelines
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2006)Food-based dietary guidelines (FBDG) are guidelines derived from nutrient targets which are translated into food-based guidelines so they can be adopted by the general population. In order for FBDG to be successful, they ... -
Genetic association study of coeliac disease in the Irish population
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2007)The aim of the present study was to investigate the genetic contribution of genes or regions other than the HLA to coeliac disease (CD) susceptibility in the Irish population. Genes selected for analysis in this study were ... -
Inflammation and oesophageal cancer : a study of genetic polymorphisms
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2007)Cancer is a major medical challenge of this era. About one in every three persons develops cancer in his lifetime. By the time they are diagnosed, most cancers have already metastasized. The treatment of cancer depends ... -
New biochips for a three-dimensional study of transendothelial leukocyte migration
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2011)An important step in the inflammatory response is the recruitment of leukocytes into tissues through the endothelial cells which line blood vessels. Transendothelial migration (TEM) is the result of a multistep cascade in ... -
Migration of lymphoma and lymphocyte T cells on flat and grooved microfabricated surfaces : comparative analysis of peripheral blood T lymphocytes and lymphoma human T cell line HUT78
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2003)Normal and malignant cell migration represents a fundamentally important process involved in tissue growth and development, inflammation and cancer metastasis. Leukocyte trafficking from blood into tissues is currently ... -
Orthostatic Hypotension as a marker of Frailty in Older People
(Trinity College Dublin, School of Medicine, Department of Medical Gerontology, 2011)This doctoral investigation endeavoured to explore the association between orthostatic hypotension (OH) and frailty in community-dwelling older people, in order to assess the validity of to-date untested, clinically grounded ...
