Clinical Medicine (Theses and Dissertations): Recent submissions
Now showing items 321-340 of 355
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Clinicopathological and inflammatory prognostic factors in non-small cell lung cancer
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2010)Lung cancer is the most common cause of cancer death worldwide. Despite improvements in diagnosis and treatments, the overall prognosis for patients with lung cancer remains poor and novel therapeutic approaches are required. ... -
Investigating the role of DNA hypermethylation as a key controller of aberrant cell death in prostate cancer
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2010)Prostate cancer remains a global public health problem. Worldwide, it is the most common noncutaneous cancer in men and is a leading cause of cancer- related deaths among men in North America and Westem\Northem Europe. ... -
Effects of polyunsaturated fatty acids on mediators of inflammation associated with atherosclerosis
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2006)The inflammatory pathogenesis of atherosclerosis has been defined, largely by the “response to injury” hypothesis. The morphological development of atherosclerosis has also been defined. Monocytes and lymphocytes accumulate ... -
Proteomic and cell based approaches for the study of the intestinal epithelial response to Helicobacter pylori soluble components in an ex vivo model of ulcerogenesis
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2008)The aim of the present study was to investigate the effects of secreted components of the gastrointestinal pathogen H. pylori on the duodenal epithelium in humans. The effects of H. pylori are not only mediated by direct ... -
Intestinal microsomal triglyceride transfer protein, promoter region polymorphisms and postprandial lipoproteins in Type 2 Diabetes
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2007)Microsomal triglyceride transfer protein is an ancient lipid transfer protein responsible for the assembly of chylomicrons in the intestine and very low density lipoproteins in the liver. Common MTP gene promoter region ... -
Conjugated lineolic acid and insulin sensitivity : insights from metabolic and molecular markers
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2006)Insulin resistance signifies an impaired biological response to insulin, and usually implies resistance to the effects of insulin on glucose uptake, metabolism, or storage. This defect is commonly observed in type 2 diabetes ... -
The interaction between dietary fatty acids and inflammation on insulin sensitivity
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2008)The metabolic syndrome (MetS) has been defined as a multi-component disorder consisting of a combination of metabolic abnormalities associated with an increased risk of developing type 2 diabetes mellitus (T2DM) and ... -
Colorectal cancer screening
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2008)Colorectal cancer is a major public health burden and is the most common cause of mortality from cancer in Europe. Over the last two decades robust evidence from randomised clinical trials and case-control series have ... -
The immunogenetics of Hepatitis C Virus in a defined unique cohort
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2006)Hepatitis C virus is a major cause of liver-related morbidity and mortality worldwide as chronic infection develops in up to 80% of those infected and leads to end-stage liver disease in a significant percentage. The ... -
A promising hypoxia-inducible suicide gene therapy strategy for prostate cancer
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2008)Gene therapy targeted to hypoxic tumour cells may allow selective killing of malignant cells. The induction of gene expression under hypoxic conditions is governed by the activation of hypoxia-inducible factor 1 and its ... -
A novel protein NFKBIL-1 regulates the activity of key transcription factors
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2008)Inflammation is a physiological process initiated in response to an injury or infection. Proper execution of the inflammatory response requires activation of several pro- inflammatory transcription factors. Nuclear Factor ... -
Dietary fatty acids and diabetes mellitus : effect on postprandial lipoproteins and apolipoproteins
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2002)This thesis explores the relative merits of dietary polyunsaturated and monounsaturated fat in reducing the postprandial dyslipidaemia which is associated with diabetes. Of particular interest are the apolipoproteins which ... -
Factors modulating TLR2, TLR4 and HBD2 expression in respiratory epithelium in COPD
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2006)The innate immune response of the respiratory epithelium, employing mechanisms of germ-line encoded, genetically conserved pattern recognition to “non-self’ organisms, is an important component of host defence against ... -
Minimal residual disease in cancer of the oesophagus and gastro-oesophageal junction
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2009)Epithelial tumours are the most common form of cancer and are responsible for the majority of cancer-related deaths in Western industrialized countries. Minimal residual disease following neo-adjuvant therapy or primary ... -
A study of postprandial lipoprotein metabolism and glycaemic control in a population with type 2 diabetes mellitus
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2010)Postprandial hypertriglyceridaemia predicts cardiovascular disease and is a characteristic of both obesity and poorly controlled diabetes. To address the relative impact of improved glycaemic control and weight loss on ... -
A novel inflammatory mediator in sinus disease
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2006)Rhinosinusitis is one of the three most common disorders presenting to primary care physicians, generating high socioeconomic costs (Moss and Parsons 1986; Poole 1999). Understanding the pathomechanisms of inflammation, ... -
Differential gene expression in diabetes : effects on postprandial lipoproteins
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2006)Diabetes is responsible for a large increase in cardiovascular risk which in many studies has not been reduced by improvement in blood sugar. The postprandial period in diabetes is associated with considerable disturbance ... -
The immune response to Hepatitis C host genetic factors influencing the out-come of Hepatitis C viral infection, in a cohort infected from a single source
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2008)The Immune response to Hepatitis C; Host genetic factors influencing the out-come of Hepatitis C viral infection, in a cohort infected from a single source. A coordinated response from both the innate and adaptive arms of ... -
Development of a tissue-specific prodrug activation approach to prostate cancer gene therapy
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2006)Prostate cancer is the most common fatal cancer in Irish men after lung and colorectal cancer. Since the risk of prostate cancer rises with age, its impact is likely to increase as the population ages. Standard treatments ... -
Investigation of gene amplification and expression in prostate cancer
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2007)The purpose of this thesis was to identify significant genetic amplifications and protein expression of a gene or genes that have not been recognised as overamplified to date in prostate cancer. Methods used: -- 1) ...
