Clinical Medicine (Theses and Dissertations): Recent submissions
Now showing items 61-80 of 355
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Lymph node status and coagulation biomarkers as predictors of venous thromboembolism in gynaecological cancer patients post surgery
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2024)Venous thromboembolism (VTE) is a major complication of cancer ranging from 4- 20% depending on tumour type and stage. VTE risk increases post-surgical treatment especially in the first 90 days post-surgery. The precise ... -
Neuroimaging features of Amyotrophic Lateral Sclerosis
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2024)Novelty: Because the vast majority of ALS imaging studies focus on evaluating motor pathology, the focus and novelty of this work is the nuanced characterisation of extra-motor involvement in a genetically stratified cohort ... -
Early Satiety in Cancer: An Investigation into a Highly Impactful Orphan Symptom
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2024)Patients with cancer experience multiple symptoms throughout the different stages of cancer care. One common symptom related to nutritional intake is known as early satiety. This symptom has no agreed definition but has ... -
Early Immune Responses to Emerging and Enduring Respiratory Pathogens
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2024)For most of recent history, Tuberculosis (TB) has been the leading cause of death by an infective agent worldwide. Tuberculosis is caused by Mycobacterium tuberculosis (Mtb), which infects human lungs following respiratory ... -
An Investigation into Helicobacter pylori Treatment Outcomes and Host Responses
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2023)Helicobacter pylori (H. pylori) is a helical, gram-negative, micro-aerophilic bacterium that infects approximately 50% of the world?s population. Although many of those infected will be asymptomatic, H. pylori increases ... -
A convergent parallel mixed methods study of the end-of-life care experiences of people with intellectual disability in Ireland: Lessons learned from IDS TILDA.
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2023)Palliative care is a vital intervention to relieve the suffering of people living with, and dying from, life-limiting conditions. However, people with an intellectual disability experience inequity in their access to, and ... -
Multimodal Analysis for Brain Network Fingerprints in Parkinson's Disease Patients
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2023)Parkinson's disease is a neurodegenerative disorder that causes structural and functional abnormalities in the central nervous system. The disease leads to the development of cardinal motor symptoms, including bradykinesia, ... -
The Dietary Intake of Patients with Chronic Pancreatitis
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2023)Chronic pancreatitis is a chronic inflammatory disorder that results in destruction of the endocrine and exocrine function of the pancreas. Due to loss of function, most patient suffer from malabsorption and malnutrition. ... -
THE DISTINCT AND AGGRESSIVE PATHOGENESIS OF ARTHRITIS IN CHILDREN WITH DOWN SYNDROME
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2023)Juvenile idiopathic arthritis (JIA) is the most common form of inflammatory arthritis (IA) in children. However, recently we described a more aggressive form of IA in children with Down syndrome (DS), termed Down syndrome ... -
Immune Dysfunction and Inflammageing in NAFLD
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2023)With a global prevalence of 25-40%, non-alcoholic fatty liver disease (NAFLD) is fast becoming the commonest cause of liver disease in the developed world [1]. Defined as increased hepatic lipid accumulation, approximately ... -
Nursing home staff mental health during the COVID-19 pandemic in the Republic of Ireland
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2023)This thesis comprises three main studies. The aim of this project was to characterise nursing home staff mental health during the COVID-19 pandemic in the Republic of Ireland. Study 1: Cross-sectional survey of nursing ... -
A Longitudinal Study of the Complex Needs of Motor Neuron Disease Caregivers
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2023)Motor Neuron Disease (MND) is the term used to describe a number of terminal incurable neurodegenerative disorders, of which Amyotrophic Lateral Sclerosis (ALS) is the most common type. MND is characterised by the progressive ... -
Leveraging a national patient registry to explore relapse in ANCA associated vasculitis
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2023)BACKGROUND ANCA associated vasculitis (AAV) is an archetypal rare autoimmune disease, resulting in immune-mediated organ damage. It has a relapsing-remitting course, resulting in cumulative morbidity and mortality. Toxic ... -
The Neuroimaging Features of Frontotemporal Dementia: Characterising Phenotype-Associated Pathological Changes In Vivo
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2023)Frontotemporal dementia (FTD) is a rare type of dementia. It can affect language, behaviour and memory depending on what part of the brain is involved. It can be difficult to diagnose, especially in the early stages of ... -
Real-world outcomes with recombinant factor IX Fc fusion protein in people with haemophilia B in Ireland
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2023)Haemophilia B is a rare X-linked bleeding disorder resulting from a deficiency of clotting factor IX (FIX), with severe haemophilia B defined as FIX levels < 0.01 IU/mL. Severe haemophilia is characterised by haemarthrosis, ... -
A Longitudinal Study of the Evolution of Neuropsychological Change in Amyotrophic Lateral Sclerosis: The Incidence, Nature and Progression of Language Impairment.
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2020)Background: Amyotrophic Lateral Sclerosis is a multi-system disease that also affects cognition and behaviour. Cognitive change in ALS manifests most commonly as executive dysfunction. Although changes in language function ... -
COVID-19 in Irish Hospital Healthcare Workers; SARS-CoV-2 antibody prevalence, epidemiology of infection and antibody response to vaccination
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2023)Background Hospital healthcare workers (HCW) are at increased risk of contracting COVID-19 infection. We aimed to determine the seroprevalence of SARS-CoV-2 antibodies in HCW in Ireland in two locations with diverging ... -
Physical functioning and health-outcomes following hospitalisation with COVID-19: a longitudinal cohort study
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2023)Introduction: A novel coronavirus (severe acute respiratory syndrome coronavirus 2; SARS-CoV-2) emerged in Wuhan, China in late 2019, causing an outbreak of viral pneumonia. Initial studies published focused on the management ... -
Novel Mechanisms of Resistance to Enzalutamide in Prostate Cancer
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2023)Prostate cancer (PCa) is the second most common invasive cancer in men worldwide. In Ireland, PCa is the third leading cause of male cancer related mortality. AR directed therapies have remained the primary therapeutic ... -
An Analysis of the Biopsychosocial Factors including Sex and Pregnancy in Women with Axial Spondyloarthritis; Data from the Ankylosing Spondylitis Registry of Ireland (ASRI)
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2023)With advances in pathophysiology, development of novel classification criteria and the advent of new therapeutic agents the field of axial spondyloarthritis (axSpA) is rapidly evolving. Despite this, the impact and interplay ...
