Clinical Medicine (Theses and Dissertations): Recent submissions
Now showing items 81-100 of 355
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Frail by four different measures and new adverse events from lower blood pressure control in hypertensive older adults: a 2-year prospective study in The Irish Longitudinal Study on Ageing (TILDA)
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2023)Frail by four different measures and new adverse events from lower blood pressure control in hypertensive older adults: a 2-year prospective study in The Irish Longitudinal Study on Ageing (TILDA) Student: Patrick O?Donoghue ... -
The Impact of Socio-Demographic and Clinical Factors on Acute Medical Service Utilisation
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2023)Socio-economic status impacts health throughout the lifecycle. It does this by affecting income, accommodation, access to education and skills, and access to healthcare. This mediates the phenotypic expression of disease ... -
Optimising the In-Hospital Management of Hip Fracture Using the Irish Hip Fracture Database
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2023)Hip fracture can have a devastating impact on older adults as it is associated with reduced life expectancy, loss of independence and poorer quality of life. Each year in Ireland approximately 3,600 patients experience a ... -
Investigating Molluscum Contagiosum Virus Protein MC008 and its Effect on Inflammatory Signalling
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2023)Molluscum contagiosum virus (MCV) is a human-adapted poxvirus that causes a common, persistent, yet mild infection characterized by distinct, contagious, papular skin lesions. These lesions are notable for having little ... -
Physical function in community-dwelling older adults - a focus on health inequality and ageing in place
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2023)This thesis sought to explore socioeconomic determinants of physical function in community-dwelling older adults, with implications for ageing in place. While several markers of physical function are explored in this thesis, ... -
Radioiodine Dosimetry for Benign and Malignant Thyroid Disease
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2023)Thyroid diseases are a common clinical disorder with 5-10% diagnosed as thyroid cancer. The published guidelines that provide clinical guidance for the diagnosis, treatment and management of thyroid diseases, based on a ... -
The frail brain
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2023)Background and aims: Frailty in older adults has been associated with reduced brain health and greater risk of cognitive decline. However, structural and functional brain signatures of frailty remain understudied, with ... -
Mucosal Associated Invariant T Cells and Insulin Resistance in Hidradenitis Suppurativa
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2023)Hidradenitis suppurativa (HS) is a chronic, inflammatory skin disease characterised by recurrent painful nodules, abscesses and draining sinus tracts. There is a paucity of effective treatments and it severely impairs ... -
The Pathological Associations of Hyperuricaemia in Sub-Clinical Gout, Cardiovascular and Cardiopulmonary Diseases
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2023)Abstract - Introduction Gout is a common and treatable disease caused by the deposition of MSU crystals in articular and non-articular structures. Hyperuricaemia is the most important risk factor for the development of ... -
Human Papilloma Virus Associated Oropharyngeal Squamous Cell Carcinoma: Genetic Aberrations Associated with Local and Distant Recurrence
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2023)Introduction HPV driven OPSCC proffers a more favourable prognosis in contrast to its HPV negative counterparts. Consequently, studies have analysed de-intensification measures of current treatment practices to minimise ... -
Predictive Microbiome Post-Bone Marrow Transplantation and Acute Graft versus Host Disease
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2023)Haemopoietic stem-cell transplantation serves as one of the life-saving options for the management of refractory haematological malignancies and rarely for non-malignant conditions. The era of transplantation has significantly ... -
Cerebral changes in Poliomyelitis survivors: A computational neuroimaging study
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2023)Post-polio syndrome (PPS) is a slowly progressive LMN condition that affects 20-85% of polio survivors many decades after their initial acute infection. While motor dysfunction is the hallmark of the disease, extra-motor ... -
A Cost-effectiveness Analysis of Human Immunodeficiency Virus, Hepatitis B Virus, and Hepatitis C Virus Screening in an Emergency Department in Ireland.
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2023)Background: The acceptability and utility of screening for HIV, HBV, and HCV in the ED has been demonstrated. Previous studies have reported cost-effectiveness of screening for either HIV mono-infection or HBV/HCV co-infection ... -
NRF2 in liver injury and repair: its relevance to liver transplantation
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2022)Liver transplantation is the only effective curative treatment for end-stage liver disease and modern-day practice has led to excellent survival outcomes. Ensuring access to suitable allografts remains crucial as patients ... -
Towards Closing the Care Gap in Bone Health in Gynaecological Oncology
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2022)Loss of bone mineral density (BMD) resulting in osteopaenia, or osteoporosis is relatively common in women, particularly postmenopausal women. Women with gynaecological malignancies are at particular risk due to the effect ... -
Mental Disorders in Older Adults Admitted to General Hospitals: Review of Patient, Service Provision and Environmental Factors
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2022)The prevalence of mental illnesses in older general hospital inpatients has been studied widely however data from the Irish population is lacking. Psychiatry of Old Age Liaison (`POA Liaison¿) services provide assessment ... -
Investigation of retinal thickness using optical coherence tomography: a prospective phenotype study of patients with inherited ataxia
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2022)Inherited cerebellar ataxias (CA) are clinically and genetically heterogeneous disorders. A diverse range of ophthalmic abnormalities have been reported in different subtypes of CA and, although visual symptoms are not ... -
Prospective Study of a Novel Diagnostic Algorithm for Investigating and Managing Gastrointestinal Disease Through The Appropriate Use of Biomarkers and Wireless Based Capsule Endoscopy
This chapter gives a general outline of the thesis for better understanding of issues surrounding research areas and studies that have been performed. Lower Gastrointestinal (GI) Symptoms are common and often warrant further ... -
The Plasticity of Neutrophil Subsets in Inflammation
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2022)Neutrophils are a vital component of the innate immune system and the body s first line of defense against invading pathogens. The classic view of these cells is that they are a homogenous population of terminally ... -
An exploration of the role of the clinical academic and strategies to sustain and build the clinical academic workforce
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2022)Background Clinical academics are critical to delivering high quality patient care and discovering new ways to treat disease (1), however the clinical academic workforce is shrinking (2-4). There is a need to clearly ...
