Browsing Clinical Medicine (Scholarly Publications) by Sponsor "Health Research Board (HRB)"
Now showing items 1-20 of 26
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Blockade of B7-H1 (Programmed Death Ligand 1) Enhances Humoral Immunity by Positively Regulating the Generation of T Follicular Helper Cells
(2011)T follicular helper (TFH) cells are critical initiators in the development of T cell-dependent humoral immunity and the generation of protective immunity. We demonstrate that TFH cell accumulation and Ab production are ... -
Data driven subclassification of ANCA associated vasculitis: model-based clustering of the FAIRVASC cohort
(2024)Background: Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis is a heterogenous autoimmune disease. While traditionally stratified into two conditions, granulomatosis with polyangiitis (GPA) and microscopic ... -
Data quality and patient characteristics in European ANCA-associated vasculitis registries: data retrieval by federated querying
(2024)Objectives: This study aims to describe the data structure and harmonisation process, explore data quality and define characteristics, treatment, and outcomes of patients across six federated antineutrophil cytoplasmic ... -
Do high blood folate concentrations exacerbate metabolic abnormalities in people with low vitamin B-12 status?
(2011)ABSTRACT Background: In elderly individuals with low serum vitamin B-12, those who have high serum folate have been reported to have greater abnormalities in the following biomarkers for vitamin B-12 defi- ciency: low ... -
Emergence of dysfunctional neutrophils with a defect in arginase-1 release in severe COVID-19
(2024)Neutrophilia occurs in patients infected with SARS-CoV-2 (COVID-19) and is predictive of poor outcomes. Here, we link heterogenous neutrophil populations to disease severity in COVID-19. We identified neutrophils with ... -
Environmental risk factors associated with ANCA associated vasculitis: A systematic mapping review.
(2020)Background: Anti-neutrophil cytoplasm antibody (ANCA)-associated vasculitis (AAV) is a rare multi-system autoimmune disease, characterised by a pauci-immune necrotising small-vessel vasculitis, with a relapsing and remitting ... -
Evaluation of 6 candidate genes on chromosome 11q23 for coeliac disease susceptibility: a case control study
(2010)BACKGROUND: Recent whole genome analysis and follow-up studies have identified many new risk variants for coeliac disease (CD, gluten intolerance). The majority of newly associated regions encode candidate genes with a ... -
An Exploratory Spatial Analysis of ALS Incidence in Ireland over 17.5 Years (1995 - July 2013)
(2014)Abstract Introduction There has been much interest in spatial analysis of ALS to identify potential environmental or genetically caused clusters of disease. Results to date have been inconclusive. The Irish ALS register ... -
The hydroxylase inhibitor DMOG attenuates endotoxic shock via alternative activation of macrophages and IL-10 production by B-1 cells.
(2011)Localized tissue hypoxia is a feature of infection and inflammation, resulting in the upregulation of the transcription factors HIF-1? and NF-?B via inhibition of oxygen sensing hydroxylase enzymes. Previous studies have ... -
Identifying key health system components associated with improved outcomes to inform the re-configuration of services for adults with rare autoimmune rheumatic diseases: a mixed-methods study
(2024)Background: Adults with rare autoimmune rheumatic diseases face unique challenges and struggles to navigate health-care systems designed to manage common conditions. Evidence to inform an optimal service framework for their ... -
IL-1 family members in health and disease
(2019)In 1985, two distinct cDNAs encoding proteins sharing human Interleukin-1 (IL-1) activity were described, thus defining the first two members of the IL-1 family – IL-1α and IL-1β. These potent pro-inflammatory cytokines ... -
Impaired basophil induction leads to an age-dependent innate defect in type 2 immunity during helminth infection in mice.
(2011)Parasitic-infection studies on rhesus macaque monkeys have shown juvenile animals to be more susceptible to infection than adults, but the immunological mechanism for this is not known. In this study, we investigated the ... -
Kidney Function Estimated From Cystatin C, But Not Creatinine, Is Related to Objective Tests of Physical Performance in Community-Dwelling Older Adults
(2017)Background: The burden of chronic kidney disease is highest among older adults but the significance of a diminished level of kidney function in this heterogeneous population is poorly understood. We sought to examine ... -
L-Plastin Expression in HCT 116 Colorectal Cells increases migration and ROS in an NADPH Oxidase-dependent manner
(2022)Objective: L-plastin is an action-bundling protein normally expressed in cells of haemopoietic origin but is also associated with malignant transformation. Aberrant expression of L-plastin expression correlates with tumour ... -
Maternal folate, vitamin B12 and homocysteine levels in pregnancies affected by congenital malformations other than neural tube defects.
(2011)Background— Periconceptional use of folic acid prevents most neural tube defects (NTDs). Whether folic acid and/or multivitamins can prevent other congenital anomalies is not clear. This study tested whether maternal ... -
Mycobacterium tuberculosis infection induces non-apoptotic cell death of human dendritic cells.
(2011)BACKGROUND: Dendritic cells (DCs) connect innate and adaptive immunity, and are necessary for an efficient CD4+ and CD8+ T cell response after infection with Mycobacterium tuberculosis (Mtb). We previously described the ... -
New fluorescent bile acids: Synthesis, chemical characterization, and disastereoselective uptake by Caco-2 cells of 3-deoxy 3-NBD-amino deoxycholic and ursodeoxycholic acid
(2012)Deoxycholic acid (DCA), a secondary bile acid (BA), and ursodeoxycholic acid (UDCA), a tertiary BA, cause opposing effects in vivo and in cell suspensions. Fluorescent analogues of DCA and UDCA could help investigate ... -
Ontology-based integration and querying of heterogeneous rare disease data sources - POLVAS perspective
(2025)The integration of rare disease medical databases belonging to different countries is an important problem, as a large number of observations are required for reliable statistical inference of patient data in order to ... -
Platelet Adhesion and Degranulation Induce Pro-Survival and Pro-Angiogenic Signalling in Ovarian Cancer Cells
(2011)Thrombosis is common in ovarian cancer. However, the interaction of platelets with ovarian cancer cells has not been critically examined. To address this, we investigated platelet interactions in a range of ovarian cancer ... -
Presymptomatic and longitudinal neuroimaging in neurodegeneration: from snapshots to motion picture - a systematic review
(2015)Background Recent quantitative neuroimaging studies have been successful in capturing phenotype and genotype-speci fi c changes in dementia syndromes, amyotrophic lateral sclerosis, Parkinson ’ s disease and other ...
