Clinical Medicine (Scholarly Publications): Recent submissions
Now showing items 21-40 of 648
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Capsule endoscopy with artificial intelligence-assisted technology: Real-world usage of a validated AI model for capsule image review
(2023)Background and study aims Capsule endoscopy is a time-consuming procedure with a significance error rate. Artificial intelligence (AI) can potentially reduce reading time significantly by reducing the number of images ... -
Estimation of coherence using the median is robust against EEG artefacts
(2017)Coherence is a mathematical measure of correlation in the frequency domain, commonly used to quantify the oscillatory synchrony of bio-signals such as the electroencephalogram (EEG). In biomedical applications, such as ... -
Prognostication in advanced cancer by combining actigraphy-derived rest-activity and sleep parameters with routine clinical data: an exploratory machine learning study
(2023)Survival prediction is integral to oncology and palliative care, yet robust prognostic models remain elusive. We assessed the feasibility of combining actigraphy, sleep diary data, and routine clinical parameters to ... -
Clinically-assisted hydration in patients in the last days of life (?CHELSEA II? trial): a cluster randomised trial
(2022)Introduction Provision of clinically assisted hydration (CAH) at the end of life is one of the most contentious issues in medicine. The aim of the ‘CHELsea II’ trial is to evaluate CAH in patients in the last days of life. ... -
Development of SIRT1 siRNA-carrying liposomes for treatment of prostate cancer
(2020)Sirtuin 1 (SIRT1) is a histone deacetylase (HDAC) from Sirtuin family and high expression of it induces activation of DNA repairing factors eventually leading either tumor suppression or tumor development in cellular ... -
Evaluation of the effect of solid and cationic lipids on siRNA delivery systems
(2020)This study aims to develop nanoparticles with different types of solid and cationic lipids and evaluate them as siRNA delivery systems. For this purpose, we prepared a series of lipid nanoparticles by combining cationic ... -
A promising approach to develop nanostructured lipid carriers from solid lipid nanoparticles: preparation, characterization, cytotoxicity and nucleic acid binding ability
(2020)We aimed to develop nanostructured lipid carriers (NLCs) displaying similar characteristics – particle size, polydispersity index, and zeta potential – with the model solid lipid nanoparticles (SLNs) for better comparability. ... -
Development of EphA2 siRNA-loaded lipid nanoparticles and combination with a small-molecule histone demethylase inhibitor in prostate cancer cells and tumor spheroids.
(2021)Background siRNAs hold a great potential for cancer therapy, however, poor stability in body fluids and low cellular uptake limit their use in the clinic. To enhance the bioavailability of siRNAs in tumors, novel, safe, ... -
Implementation of 26 Gy in five fractions over 1 week adjuvant radiotherapy for breast cancer: Prospective report of acute skin toxicity and consideration of resource implications
(2023)Purpose: In March 2020, a 1-week adjuvant breast radiotherapy schedule, 26 Gy in 5 fractions, was adopted to reduce the risk of COVID19 for staff and patients. This study quantifies acute toxicity rates and the effect ... -
Comparing Colon Capsule Endoscopy To Colonoscopy; A Symptomatic Patient?s Perspective
(2022)Background Colon Capsule Endoscopy (CCE) has proven efficacy in a variety of gastrointestinal diseases. Few studies have assessed patient-reported outcomes and preference between colonoscopy and CCE. Methods Patients ... -
Single or double headed capsules for the investigation of suspected small bowel bleeding: Are two heads better than one.
(2022)Background: Capsule endoscopy is now the accepted first line investigation for suspected small bowel (SB) bleeding. Recent evidence suggests the diagnostic yield for SB pathology may be higher for tailored double headed ... -
Small-bowel capsule endoscopy and device-assisted enteroscopy for diagnosis and treatment of small-bowel disorders: European Society of Gastrointestinal Endoscopy (ESGE) Guideline - Update 2022.
(2023)This Guideline is an official statement from the European Society of Gastrointestinal Endoscopy (ESGE). It is an update of the previously published 2015 ESGE Clinical Guideline addressing the role of small-bowel ... -
Key research questions for implementation of artificial intelligence in capsule endoscopy.
(2022)Background: Artificial intelligence (AI) is rapidly infiltrating multiple areas in medicine, with gastrointestinal endoscopy paving the way in both research and clinical applications. Multiple challenges associated with ... -
L-Plastin Expression in HCT 116 Colorectal Cells increases migration and ROS in an NADPH Oxidase-dependent manner
(2022)Objective: L-plastin is an action-bundling protein normally expressed in cells of haemopoietic origin but is also associated with malignant transformation. Aberrant expression of L-plastin expression correlates with tumour ... -
Oral symptom assessment tools in patients with advanced cancer: a scoping review
(2022)Purpose: Oral symptoms are common in patients with advanced cancer. The aim of this scoping review was to identify oral symptom assessment tools that have been specifically utilised in patients with "advanced cancer". Methods: ... -
MASCC/ISOO expert opinion on the management of oral problems in patients with advanced cancer
(2022)Purpose: The Palliative Care Study Group in conjunction with the Oral Care Study Group of the Multinational Association for Supportive Care in Cancer (MASCC) formed a sub-group to develop evidence-based guidance on the ... -
Multinational Association of Supportive Care in Cancer (MASCC) expert opinion/guidance on the use of clinically assisted nutrition in patients with advanced cancer
(2022)Purpose: The pro vision of clinically assisted nutrition (CAN) in patients with advanced cancer is controversial, and there is a paucity of specific guidance, and so a diversity in clinical practice. Consequently, the ... -
Palliative care in the era of novel oncological interventions: needs some �tweaking�
(2022)Cancer treatment has evolved enormously over the last 20 years, with developments in surgery, radiotherapy, chemo- therapy, targeted therapy, and immunotherapy. As a result, many cancer patients have improved outcomes ... -
A prospective, real-world, multinational study of naloxegol for patients with cancer pain diagnosed with opioid-induced constipation - the NACASY Study
(2022)The Naloxegol Cancer Study (NACASY) was a multinational European study aimed to evaluate the 4-week safety and efficacy of naloxegol in a real-world setting in patients with cancer pain diagnosed with opioid-induced ...
