Clinical Medicine (Scholarly Publications): Recent submissions
Now showing items 501-520 of 648
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Habitual physical activity and cardiometabolic risk factors in adults with cerebral palsy
(2014)Adults with cerebral palsy (CP) are known to participate in reduced levels of total physical activity. There is no information available however, regarding levels of moderate-to-vigorous physical activity (MVPA) in this ... -
MHCII-Mediated Dialog between Group 2 Innate Lymphoid Cells and CD4(+) T Cells Potentiates Type 2 Immunity and Promotes Parasitic Helminth Expulsion.
(2014)Group 2 innate lymphoid cells (ILC2s) release interleukin-13 (IL-13) during protective immunity to helminth infection and detrimentally during allergy and asthma. Using two mouse models to deplete ILC2s in vivo, we demonstrate ... -
Using Action Research and Peer Perspectives to Develop Technology That Facilitates Behavioral Change and Self-Management in COPD
(2014)Background. Behavioural change and self-management in patients with chronic illness may help to control symptoms, avoid rehospitalization, enhance quality of life, and decrease mortality and morbidity. Objective. Guided ... -
The relationship between syncope, depression and anti-depressant use in older adults
(2014)The authors aim to examine the rates of depression in older patients reporting syncope and the effect of anti–depressants (ADs) on the rates of syncope. This study demonstrates an increased risk of syncope in patients with ... -
Seasonal variation of serum vitamin D and the effect of vitamin D supplementation in Irish community-dwelling older people.
(2011)BACKGROUND: Ireland is at 53°N, and its population risk of vitamin D deficiency is high. Previous Irish studies suggested a significant seasonality of serum 25-hydroxyvitamin D [25(OH)D] and a beneficial effect of ... -
The effect of sleeping with the head of the bed elevated six inches on elderly patients with orthostatic hypotension: an open randomised controlled trial.
(2011)the evidence for 6-inch tilt sleeping-head-up (SHU), a common therapy for the treatment of orthostatic hypotension (OH) in older people, is unavailable.; to investigate the effects of 6-inch SHU for 6 weeks in community-living ... -
Postal questionnaire survey: the use of sleeping with the head of the bed tilted upright for treatment of orthostatic hypotension in clinical practice.
(2006)Orthostatic hypotension (OH) is common and affects one in five community-living older persons [1]. The incidence is higher amongst older in-patients [2] and those attending a syncope clinic [3]. The treatment of OH is ... -
Correlates of frailty in Alzheimer's disease and mild cognitive impairment.
(2011)The global prevalence of dementia is rising with Alzheimer's disease (AD) accounting for 50–60% of all cases and mild cognitive impairment (MCI) its precursor [1, 2]. Although the clinical hallmark of AD is progressive ... -
Diabetes mellitus and apoptosis:inflammatory cells
(2009)Since the early observation that similarities between thyroiditis and insulitis existed, the important role played by inflammation in the development of diabetes has been appreciated. More recently, experiments have shown ... -
Filaggrin-stratified transcriptomic analysis of pediatric skin identifies mechanistic pathways in patients with atopic dermatitis.
(2014)Background Atopic dermatitis (AD; eczema) is characterized by a widespread abnormality in cutaneous barrier function and propensity to inflammation. Filaggrin is a multifunctional protein and plays a key role in skin barrier ... -
Insulin receptor substrate 2 and FozO3a signaling are involved in E-Cadherin expression and transforming growth factor-β1-induced repression in kidney epithelial cells
(2011)Insulin receptor substrate (IRS) proteins comprise a family of adaptor molecules that integrate extracellular signals from insulin and other ligands to intracellular effectors such as phosphoinositide 3-kinase and mitogen ... -
Identification of transcriptional targets associated with the expression of p210 Bcr-Abl
(2006)Objectives: Chronic myeloid leukaemia is caused by the expression of the p210 Bcr-Abl fusion protein which results from the Philadelphia translocation, t(9;22). This oncogene has been the focus of extensive research. ... -
Chemotherapeutic compounds targeting the DNA double-strand break repair pathways: the good, the bad, and the promising.
(2014)The repair of DNA double-strand breaks (DSBs) is a critical cellular mechanism that exists to ensure genomic stability. DNA DSBs are the most deleterious type of insult to a cell’s genetic material and can lead to genomic ... -
Functions and therapeutic roles of exosomes in cancer.
(2014)The role of exosomes in cancer development has become the focus of much research, due to the many emerging roles possessed by exosomes. These micro-vesicles that are ubiquitously released in to the extracellular milieu, ... -
2nd ESMO Consensus Conference on Lung Cancer: early-stage non-small-cell lung cancer consensus on diagnosis, treatment and follow-up.
(2014)To complement the existing treatment guidelines for all tumour types, ESMO organises consensus conferences to focus on specific issues in each type of tumour. The 2nd ESMO Consensus Conference on Lung Cancer was held on ... -
The establishment of an ISO compliant cancer biobank for Jordan and its neighboring countries through knowledge transfer and training.
(2014)Research studies aimed at advancing cancer prevention, diagnosis, and treatment depend on a number of key resources, including a ready supply of high-quality annotated biospecimens from diverse ethnic populations that can ... -
Targeting nuclear factor-kappa B to overcome resistance to chemotherapy.
(2013)Intrinsic or acquired resistance to chemotherapeutic agents is a common phenomenon and a major challenge in the treatment of cancer patients. Chemoresistance is defined by a complex network of factors including multi-drug ... -
Genome stability pathways in head and neck cancers.
(2013)Genomic instability underlies the transformation of host cells toward malignancy, promotes development of invasion and metastasis and shapes the response of established cancer to treatment. In this review, we discuss recent ... -
IL-23R is Epigenetically Regulated and Modulated by Chemotherapy in Non-Small Cell Lung Cancer.
(2013)The Interleukin-23 (IL-23)/IL-23R signaling axis is an important inflammatory pathway, involved in the stimulation and regulation of the T helper (Th) 17 lymphocytes, resulting in the production of IL-17. Aside from ... -
Prognostic and therapeutic relevance of FLIP and procaspase-8 overexpression in non-small cell lung cancer
(2013)Non-small cell lung carcinoma remains by far the leading cause of cancer-related deaths worldwide. Overexpression of FLIP, which blocks the extrinsic apoptotic pathway by inhibiting caspase-8 activation, has been identified ...
