Genetics (Theses and Dissertations): Recent submissions
Now showing items 101-120 of 218
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A study of the regulation of aminoacyl tRNA synthetase gene expression in Bacillus by T-box regulatory elements
(Trinity College (Dublin, Ireland). School of Genetics and Microbiology, 2010)The T-box antitermination mechanism is commonly used for the regulation of aminoacyl tRNA synthetase gene expression in Gram positive bacteria. However, expression of lysyl tRNA synthetases is rarely controlled in this ... -
Expression of hns and stpA in Salmonella enterica servoar Typhimurium
(Trinity College (Dublin, Ireland). School of Genetics and Microbiology, 2012)H-NS-like proteins are widespread amongst Enterobacteriaceae and other Gramnegative bacteria. They are small (15 kDa) nucleoid associated proteins involved in many cellular processes such as replication, transposition, ... -
Investigation of the role of the BcI-2 family proteins in Ras-induced transformation
(Trinity College (Dublin, Ireland). Department of Genetics, 2011)RAS is a proto-oncogene that is found mutated in 25% of human tumours. Deregulated Ras expression is typically insufficient to transform cells as it triggers anti-proliferative responses that altogether limit tumorigenesis. ... -
Population and genomic variation of immune genes in chicken
(Trinity College (Dublin, Ireland). Department of Genetics, 2010)Achieving an understanding of the processes shaping diversity at chicken immune genes illuminates their population history, relevance to disease and mechanisms of evolution. Functional variation at genes that determine the ... -
Functional analyses of a novel leucine-rich repeat-containing protein, Elfn1, in the mouse
(Trinity College (Dublin, Ireland). Department of Genetics, 2013)The functional brain is critically dependent on a highly specific and perfectly timed gene-expression programme that underlies neuronal connectivity. Each step of this process, which includes cell migration, axon guidance, ... -
Exploring the role of granzymes in the induction of apoptosis
(Trinity College (Dublin, Ireland). Department of Genetics, 2009)Cytotoxic Lymphocytes (CTL) and Natural Killer (NK) cells provide the body with a powerful defence against viral infection, intracellular pathogens and tumor development. After identifying an infected or damaged cell, ... -
Controlled expression and functional characterisation of SasG - a surface protein of Staphylococcus aureus
(Trinity College (Dublin, Ireland). School of Genetics and Microbiology, 2009)Staphylococcus aureus colonises the moist squamous epithelium of the anterior nares. One of the adhesins likely to be responsible is the S. aureus surface protein G (SasG) which has sequence similarity with the proteins ... -
Genetic resistance to Campylobacter jejuni colonization in the chicken
(Trinity College (Dublin, Ireland). School of Genetics and Microbiology, 2011)Campylobacter colonization levels within the chicken gastrointestinal tract vary substantially between individual chickens and this variation in colonization susceptibility can be heritable. In this work the genetic ... -
Investigation of the molecular mechanisms of functional innovation
(Trinity College (Dublin, Ireland). School of Genetics and Microbiology, 2012)The robustness to perturbations and evolvability of genomes are two major principles that govern the emergence of genetic diversity across all forms of life. Functional innovations that occur through the genetic diversity ... -
The role of granzyme B and other granule proteases as modulators of cytokine activity
(Trinity College (Dublin, Ireland). Department of Genetics, 2012)Excerpt from introduction: In all vertebrate organisms a properly functioning immune system is absolutely required for protection against infectious agents and also acts as a safeguard against tumour development. Over time ... -
Genetic mechanisms establishing thalamocortical connectivity : novel genes and a role for Semaphorin6B
(Trinity College (Dublin, Ireland). Department of Genetics, 2015)One of the main functions of the brain is to process information from the environment. All input to the neocortex passes through the thalamus in order to be handled. Therefore, proper connectivity between the thalamus and ... -
A molecular genetic investigation of Irish origins
(Trinity College (Dublin, Ireland). Department of Genetics, 2000)Three hundred and ninety-four male DNA samples, from Ireland, Turkey and Togo, were genotyped for 5 X chromosome simple tandem repeat (STR) loci. Six Y chromosome STR loci and 8 Y chromosome unique event polymorphisms were ... -
Testing the hypothesis of genome duplications in vertebrates
(Trinity College (Dublin, Ireland). School of Genetics and Microbiology, 2000)The hypothesis that the human genome has undergone at least two rounds of genome duplication has become widely accepted, but has never been rigorously tested. In this study, several map-based inter- and intra-species ... -
Gene order evolution and genomic analyses of the model eukaryote, Saccharomyces cerevisiae, and other yeast species
(Trinity College (Dublin, Ireland). School of Genetics and Microbiology, 2000)The complete genome sequence of the yeast Saccharomyces cerevisiae can be used to form a clearer picture of the evolution of the diverse species of yeast and to construct a model of eukaryote genome evolution. In this study ... -
Family-based molecular genetic studies in bipolar affective disorder
(Trinity College (Dublin, Ireland). Department of Genetics, 2003)This thesis covers gene mapping experiments applied to bipolar affective disorder (BPD), a severe recurrent psychiatric condition with a lifetime prevalence of 1-2%, and a substantial familial component. The study sample ... -
Genome sequencing and functional genomics in Bacillus subtilis : the expression and roles of the superoxide dismutases and NADH dehydrogenases
(Trinity College (Dublin, Ireland). Department of Genetics, 2002)The work in this thesis spans genome sequencing of Bacillus subtilis, functional analysis of genes of unknown function and more detailed characterisation of the function and regulation of specific genes. Approximately 0.7% ... -
Trypanotolerace in West African cattle and the population genetic effects of selection
(Trinity College (Dublin, Ireland). Department of Genetics, 2002)A panel of 69 microsatellite loci was used to investigate the population genetic effects of selection at genes on linked, neutral markers. Loci were typed in African and European Bos taurus cattle and Bos indicus populations ... -
Molecular and quantative analyses of genetic variation in farmed Atlantic salmon
(Trinity College (Dublin, Ireland). Department of Genetics, 2003)Genetic diversity between three farmed and four wild populations and within six 6 year classes of one farmed population of Atlantic salmon were analysed using 15 microsatellite markers. High levels of polymorphism were ... -
A study of the expression and roles of Bacillus subtilis HtrA-type serine proteases
(Trinity College (Dublin, Ireland). Department of Genetics, 2003)Upon sequencing a region of the Bacillus subtilis genome assigned to the author of this thesis, an open reading frame encoding a homologue of an HtrA-type serine protease, YkdA, was identified. The HtrA serine protease ... -
Investigations on apoptosis-associated caspase activation cascades
(Trinity College (Dublin, Ireland). Department of Genetics, 2004)Apoptosis is an important process in a wide variety of different biological systems such as the immune system, normal cell turnover and embryonic development (Stennicke et al., 2002). Apoptosis is characterized by a series ...
