Browsing Genetics (Scholarly Publications) by Subject "Genetics"
Now showing items 41-60 of 83
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Genome survey sequencing of the wine spoilage yeast Dekkera (Brettanomyces) bruxellensis.
(American Society for Microbiology, 2007)The hemiascomycete yeast Dekkera bruxellensis, also known as Brettanomyces bruxellensis, is a major cause of wine spoilage worldwide. Wines infected with D. bruxellensis develop distinctive, unpleasant aromas due to volatile ... -
A Genome Wide Association Scan of Bovine Tuberculosis Susceptibility in Holstein-Friesian Dairy Cattle
(2012)BACKGROUND: Bovine tuberculosis is a significant veterinary and financial problem in many parts of the world. Although many factors influence infection and progression of the disease, there is a host genetic component and ... -
Genomic Features in the Breakpoint Regions between Syntenic Blocks
(Oxford University Press, 2004)MOTIVATION: We study the largely unaligned regions between the syntenic blocks conserved in humans and mice, based on data extracted from the UCSC genome browser. These regions contain evolutionary breakpoints caused by ... -
How Much Is That in Dog Years? The Advent of Canine Population Genomics
(2014)ABSTRACT The authors comment on two studies that analyzed multiple genomes of dogs and wolves. The studies reached different conclusions about the date and population effects, a disparity attributed to reliance on molecular ... -
Increased glycolytic flux as an outcome of whole-genome duplication in yeast
(BioMed Central, 2007)After whole-genome duplication (WGD), deletions return most loci to single copy. However, duplicate loci may survive through selection for increased dosage. Here, we show how the WGD increased copy number of some glycolytic ... -
An infection-relevant transcriptomic compendium for Salmonella enterica Serovar Typhimurium.
(2013)Bacterial transcriptional networks consist of hundreds of transcription factors and thousands of promoters. However, the true complexity of transcription in a bacterial pathogen and the effect of the environments encountered ... -
Inhibitor of Apoptosis Proteins (IAPs) and Their Antagonists Regulate Spontaneous and Tumor Necrosis Factor (TNF)-induced Proinflammatory Cytokine and Chemokine Production.
(2013)Inhibitor of apoptosis proteins (IAPs) play a major role in determining whether cells undergo apoptosis in response to TNF as well as other stimuli. However, TNF is also highly proinflammatory through its ability to trigger ... -
Insufficient Evidence for "Autism-Specific" Genes
(2020)Despite evidence that deleterious variants in the same genes are implicated across multiple neurodevelopmental and neuropsychiatric disorders, there has been considerable interest in identifying genes that, when mutated, ... -
Interacting gene clusters and the evolution of the vertebrate immune system.
(2008)Unraveling the "code" of genome structure is an important goal of genomics research. Colocalization of genes in eukaryotic genomes may facilitate preservation of favorable allele combinations between epistasic loci or ... -
Localized hypermutation and associated gene losses in legume chloroplast genomes
(2010)Point mutations result from errors made during DNA replication or repair, so they are usually expected to be homogeneous across all regions of a genome. However, we have found a region of chloroplast DNA in plants related ... -
Mechanisms of Chromosome Number Evolution in Yeast
(PLoS, 2011)The whole-genome duplication (WGD) that occurred during yeast evolution changed the basal number of chromosomes from 8 to 16. However, the number of chromosomes in post-WGD species now ranges between 10 and 16, and the ... -
Mitochondrial fission/fusion dynamics and apoptosis
(2010)Mitochondria play an important role in the progression of apoptosis through the release of pro-apoptotic factors, such as cytochrome c, from the mitochondrial intermembrane space. During this process, mitochondrial networks ... -
A model system for studying the transcriptomic and physiological changes associated with mammalian host-adaptation by Leptospira interrogans serovar Copenhageni.
(2014)Leptospirosis, an emerging zoonotic disease with worldwide distribution, is caused by spirochetes belonging to the genus Leptospira . More than 500,000 cases of severe leptospirosis are reported annually, with . 10% ... -
Mutation of Elfn1 in mice causes seizures and hyperactivity.
(2013)A growing number of proteins with extracellular leucine-rich repeats (eLRRs) have been implicated in directing neuronal connectivity. We previously identified a novel family of eLRR proteins in mammals: the Elfns are ... -
De Novo Origins of Human Genes
(2011)Where do new genes come from? For a long time the answer to that question has simply been ?from other genes?. The most prolific source of new loci in eukaryotic genomes is gene duplication in all its guises: exon shuffling, ... -
Ohnologs in the human genome are dosage balanced and frequently associated with disease
(2010)About 30% of protein-coding genes in the human genome are related through two whole genome duplication (WGD) events. Although WGD is often credited with great evolutionary importance, the processes governing the retention ... -
Oxidative stress and growth temperature in Bacillus subtilis.
(1987)Pretreatment of Bacillus subtilis with low concentrations of hydrogen peroxide protected the cells against the lethal effects of higher levels of oxidative stress. During the period of adaptation, eight proteins were ... -
Parallel evolution of the make?accumulate?consume strategy in Saccharomyces and Dekkera yeasts
(Nature, 2011)Saccharomyces yeasts degrade sugars to two-carbon components, in particular ethanol, even in the presence of excess oxygen. This characteristic is called the Crabtree effect and is the background for the 'make?accumulate?consume' ... -