School of Genetics & Microbiology: Recent submissions
Now showing items 321-340 of 911
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Genetic admixture analysis of domesticated cattle
(Trinity College (Dublin, Ireland). Department of Genetics, 2003)Genetic admixture analysis of bovine hybrid zones was carried out through implementation of a variety of statistical and analytical methods. Population genetic analysis of microsatellite variation in seven cattle breeds ... -
Genetic variation in domesticated cattle and wild aurochsen using ancient and modern data
(Trinity College (Dublin, Ireland). Department of Genetics, 2003)A total of 101 Bos taurus teeth and bones aged between 1,000 to 9,000 years old, and 45 B. primigenius primigenius bones aged between 3,720 to 12,380 years old, were assessed for the presence of verifiable mitochondrial ... -
Characterization of two genes transcribed from a divergent promotor in Arabidopsis thaliana and encoding plastid-targeted proteins
(Trinity College (Dublin, Ireland). Department of Genetics, 2001)As part of the Arabidopsis genome sequencing project, approximately 85kb of sequence data on chromosome 4 was generated in this laboratory. This included a cosmid clone called cAt4S5 containing a genomic insert of 13.3kb ... -
Investigation of the YycFG two-component signal transduction system in Bacillus subtilis
(Trinity College (Dublin, Ireland). Department of Genetics, 2004)The work in this thesis describes a novel approach to investigating the YycFG two-component signal transduction system of Bacillus subtilis. The YycFG TCSTS was found to be the only essential two-component signal transduction ... -
Decoding the Genetics of Inherited Retinal Diseases in Ireland
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2019)Title: Decoding the Genetics of Inherited Retinal Diseases in Ireland Short Description: The Target 5000 study aims to provide genetic testing for the estimated 5,000 people in Ireland who are affected by a genetic retinal ... -
Transformation and marker gene removal strategies for the plastid genome of Brassica napus
(Trinity College (Dublin, Ireland). Department of Genetics, 2002)Despite the fact that the first transplastomic higher plant was produced more than a decade ago, transformation of the plastid genome and the regeneration of homoplasmic, fertile plants has so far been achieved in only 2 ... -
Cloning and functional characterisation of genes involved in cell death and cell survival
(Trinity College (Dublin, Ireland). Department of Genetics, 2004)During development and as a result of infection or injury, individual cells of multicellular organisms are required to mount appropriate survival or death responses. Two main signalling pathways are responsible for these ... -
Characterization of Arabidopsis homologs of the Drosophila SET domain gene Su(var)3-9
(Trinity College (Dublin, Ireland). Department of Genetics, 2004)SET domain-containing proteins encoded by the Drosophila gene Su(var)3-9 and its human homologue, SUV39H1, are major regulators of heterochromatin formation. The SET domains of these proteins carry histone methyltransferase ... -
Interaction of heat shock proteins with splicing machinery components during and after thermal stress in Saccharomyces cerevisiae
(Trinity College (Dublin, Ireland). Department of Microbiology, 2000)This thesis is a study of the amehorative effects of Heat Shock Proteins (Hsps) on the cellular process of mRNA splicing during and after thermal stress in Saccharomyces cerevisiae. Splicing is a vital process that is known ... -
On the role of caspase-recruitment domain proteins in apoptosis and NFkB activation
(Trinity College (Dublin, Ireland). Department of Genetics, 2002)Apoptosis and NFkB activation are two physiological processes that are essential for host mediated response to cellular injury. Apoptosis is a mechanism that removes damaged or unwanted cells. NFkB is a transcription factor ... -
Microevolution in Helicobacter pylori
(Trinity College (Dublin, Ireland). Department of Microbiology, 2002)Helicobacter pylori chronically colonises the human gastric mucosa. It is a major cause of chronic active gastritis and peptic ulcer disease and is associated with the development of gastric neoplasia. The population ... -
The development of gene therapy techniques and animal models for Retinitis Pigmentosa and towards the identification of a novel RP-causing gene in a family of Irish origin
(Trinity College (Dublin, Ireland). Department of Genetics, 2003)The work presented in this thesis pertains to several different stages in the preclinical development of therapeutics for inherited retinal disease. Chapter two addresses the difficult challenge of delivery of therapeutics ... -
An investigation of the role of caspase-9-interacting proteins in the molecular control of apoptosis
(Trinity College (Dublin, Ireland). Department of Genetics, 2001)Apoptosis is an important homeostatic mechanism that multicellular organisms utilize to delete cells during development and on an ongoing basis in the adult. At the molecular level, this requires the activation of a family ... -
On the molecular genetics of hereditary degenerative retinopathies
(Trinity College (Dublin, Ireland). Department of Genetics, 2004)The central aim of this thesis was the elucidation of the underlying molecular pathologies of inherited diseases of the retina. The main focus of study concentrates on the molecular genetics and disease mechanisms in ... -
Analysis of the genomic organisation and gene expression of brewery strains of yeast
(Trinity College (Dublin, Ireland). Department of Microbiology, 2008)The genomes of lager yeast arose from the fusion of two yeast strains most closely resembling Saccharomyces cerevisiae and Saccharomyces bayanus. The resultant strains have subsequently undergone genome duplications ... -
Exploration of thyrotropin releasing hormone-degrading ectoenzyme (TRH-DE) suppression and localisation in retina
(Trinity College (Dublin, Ireland). Department of Genetics, 2007)Since the identification of thyrotropin releasing hormone (TRH), and its respective degrading enzyme (thyrotropin releasing hormone degrading ectoenzyme, TRH-DE) outside of the hypothalamic-pituitary-thyroid axis, the ... -
The identification and functional characterization of substrates of the C. elegans caspase CED-3
(Trinity College (Dublin, Ireland). Department of Genetics, 2007)The founding member of the caspase family of proteases is the C. elegans caspase, CED-3. CED-3 is the only caspase required for programmed cell deaths in the worm, but we know very little about how this protease coordinates ... -
Towards a gene therapy for RP10 retinitis pigmentosa
(Trinity College (Dublin, Ireland). Department of Genetics, 2008)The main focus of this thesis is on the development of a gene therapy strategy using RNAi-mediated suppression for the RP10 form of retinitis pigmentosa (RP), which accounts for approximately 2% of all autosomal dominant ... -
Molecular genetic typing of Staphylococcus aureus from cows, goats, sheep, rabbits and chickens
(Trinity College (Dublin, Ireland). Department of Microbiology, 2006)Staphylococcus aureus is an important pathogen of man causing a range of infections from boils, carbuncles and abscesses to more serious and life-threatening infections like endocarditis and osteomyelitis. S. aureus is ... -
Comparative genomics in yeasts
(Trinity College (Dublin, Ireland). Department of Genetics, 2004)Comparative genomics allows us to delve into the fundamental differences among species that form the basis of biodiversity, as well as the preservative forces of natural selection that have left many things unchanged. It ...
