School of Genetics & Microbiology: Recent submissions
Now showing items 401-420 of 911
-
Alternative routes to optimal expression levels: Evolutionary evidence for competitive RNAs and dosage compensation by gene duplication
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2019)Expression evolution and dosage constraints are important factors shaping genomic content and innovation. It has become increasingly clear that non-coding RNAs perform various regulatory functions in different cellular ... -
Contact transmission of influenza virus between ferrets imposes a looser bottleneck than respiratory droplet transmission allowing propagation of antiviral resistance
(2016)Influenza viruses cause annual seasonal epidemics and occasional pandemics. It is important to elucidate the stringency of bottlenecks during transmission to shed light on mechanisms that underlie the evolution and propagation ... -
Ferret airway epithelial cell cultures support efficient replication of influenza B virus but not mumps virus.
(2015)Ferrets have become the model animal of choice for influenza pathology and transmission experiments as they are permissive and susceptible to human influenza A viruses. However, inoculation of ferrets with mumps virus (MuV) ... -
Glycomic characterization of respiratory tract tissues of ferrets: Implications for its use in influenza virus infection studies
(2014)The initial recognition between influenza virus and the host cell is mediated by interactions between the viral surface protein hemagglutinin and sialic acid-terminated glycoconjugates on the host cell surface. The sialic ... -
Investigating influenza virus A pleomorphy
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Microbiology, 2019)Clinical isolates of influenza A virus particles display a pleomorphic phenotype, where particles can range in size from 100 nm to 10 ?m in length while maintaining uniform diameters. Conversely, most laboratory-adapted ... -
Comparative analysis of human and mouse acute phase Serum Amyloid A gene expression
(Trinity College (Dublin, Ireland). School of Genetics and Microbiology, 2001)The Serum Amyloid A (S AA) proteins are a family of highly conserved lipoproteins secreted by the liver. Their production and release is massively induced under conditions of inflammation or infection by pro-inflammatory ... -
Therapeutic approaches to halting photoreceptor cell death in the retina
(Trinity College (Dublin, Ireland). School of Genetics and Microbiology, 2001)Retinitis pigmentosa (RP) is a group of hereditary retinopathies affecting approximately 1 in 3500 people in the developed world. The disorders are characterised by the early onset of night blindness followed by a ... -
Molecular characterisation of agn43 and its encoded protein, antigen 43, the major phase-variable outer membrane protein of Escherichia coli
(Trinity College (Dublin, Ireland). Department of Microbiology, 2001)A number of year ago workers in this laboratory identified antigen 43 (Ag43) during a systematic immunochemical analysis of the envelopes of Escherichia coli ML308-225 O13:O68:H . This Escherichia-specific outer membrane ... -
Characterisation of genotypic and phenotypic differences between Candida dubliniensis and Candida albicans
(Trinity College (Dublin, Ireland). Department of Microbiology, 2001)Summary -Candida dubliniensis is a recently described Candida species associated with oral candidosis in Human Immunodeficiency Virus (HIV)-infected and AIDS patients. The phylogenetic position of C. dubliniensis has ... -
Novel therapeutic strategies for autosomal dominant retinitis pigmentosa
(Trinity College (Dublin, Ireland). School of Genetics and Microbiology, 2000)A major difficulty associated with the design of gene therapies for autosomal dominant diseases is the immense intragenic heterogeneity often encountered in such conditions. Two strategies which circumvent the difficulties ... -
Characterisation of SdrC, SdrD and SdrE from the serine-aspartate repeat family of Staphylococcus auerus
(Trinity College (Dublin, Ireland). Department of Microbiology, 2001)Staphylococcus aureus is an important human pathogen. The ability of S. aureus to initiate infection is attributed at least partly to the expression of cell wall-associated proteins known as MSCRAMMs (microbial surface ... -
A leaf-specific phage T7 RNA polymerase-based system for transgene expression in tobacco chloroplasts
(Trinity College (Dublin, Ireland). School of Genetics and Microbiology, 2001)This thesis describes the development of a chloroplast-localised gene expression system based on the phage T7 RNA polymerase. In order to direct T7 RNAP expression in a leaf-specific manner and to target it to the ... -
Investigations into the pathogenesis of Dengue virus infections of humans : the endothelium as a target
(Trinity College (Dublin, Ireland). Department of Microbiology, 2001)The pathogenesis of the disease Dengue Haemorrhagic Fever/Dengue Shock Syndrome has not been elucidated. This study investigated the effects of Dengue virus, serotype 2 infection on both the human cell line ECV304/T-24 ... -
A bioinformatics approach to (intra-) genome comparisons
(Trinity College (Dublin, Ireland). School of Genetics and Microbiology, 2002)The analysis of large volumes of genomic data generates special computational needs. A Beowulf-type computer cluster was set up for high-performance computing. Improvements over existing tools for the efficient ... -
A novel gene-based therapy for galaucoma:from discovery to preclinical development
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2018)Introduction: Glaucoma is a multifactorial condition that will often result in complete bilateral blindness if untreated. Elevated intraocular pressure (IOP) is both a major risk factor and indicator of disease. IOP is ...
