School of Genetics & Microbiology: Recent submissions
Now showing items 381-400 of 911
-
Effect of gene structure changes on the rate of protein sequence evolution
(Trinity College (Dublin, Ireland). Department of Genetics, 2007)The elaborate architecture of the genes of niulticellular eukaryotes is likely to underpin the unique complexity of eukaryotic gene functions. The structure of eukaryotic genes differs from that of prokaryotes and represents ... -
Exploration of novel therapeutics for autosomal dominant Retinitis Pigmentosa
(Trinity College (Dublin, Ireland). Department of Genetics, 2006)This thesis is concerned with exploration of a suppression and replacement therapeutic approach for the dominant form of Retinitis Pigmentosa (ADRP). Retinitis Pigmentosa is the most heterogeneous of all hereditary disorders ... -
Investigation of Plasmodium falciparum aminopeptidases and characterisation of the M17 leucine aminopeptidase
(Trinity College (Dublin, Ireland). Department of Microbiology, 2008)Plasmodium falciparum spends part of its life cycle residing in human erythrocytes, during which time it digests much of the host cell haemoglobin to provide a source of amino acids for synthesis of its own proteins. The ... -
Evolution of the genomes of two nematodes in the genus Caenorhabditis
(Trinity College (Dublin, Ireland). Department of Genetics, 2004)The soil-dwelling nematode Caenorhabditis elegans has been intensively studied as a model organism for the last 40 years. It was the first animal for which we had a complete description of development, anatomy, a neural ... -
An investigation into the complex genetics of bipolar affective disorder : potential susceptibility loci and candidate genes from the Irish population
(Trinity College (Dublin, Ireland). Department of Genetics, 2008)Bipolar affective disorder (BPAD) is a serious and debilitating psychiatric illness characterised by extreme changes in mood, ranging from depression to mania. BPAD is undoubtedly caused by genetic factors, with some ... -
Genetic diversity of Helicobactor pylori isolates through Microevolution in vivo
(Trinity College (Dublin, Ireland). Department of Microbiology, 2004)Chronic infection with H. pylori causes peptic ulcer disease and its presence is strongly linked with gastric adenocarcinoma and mucosa-associated lymphoid tissue (MALT) lymphoma. One of the most interesting characteristics ... -
Virulence gene regulation by nucleoid associated proteins in Salmonella typhimurium : a role for Fis in Salmonella pathogenicity island 2 gene regulation
(Trinity College (Dublin, Ireland). Department of Microbiology, 2004)Nucleoid associated proteins are involved in many diverse biological functions in S. typhimurium. In addition to their structural role within the genome they have been im plicated in transcriptional regulation of a variety ... -
Biogenesis of histone mRNAs in the yeast Saccharomyces cerevisiae
(Trinity College (Dublin, Ireland). Department of Microbiology, 2007)The typical eukaryotic human diploid cell contains 3.2x10 9 base pairs of deoxyribonucleic acid (DNA) which, if presented in an extended form, would measure 1.2m in length. The large amount of DNA is tightly wrapped and ... -
Construction and characterisation of a Semliki Forest virus vector based rubella prototype vaccine
(Trinity College (Dublin, Ireland). Department of Microbiology, 2007)Alphavirus vaccines such as those based on the Semliki Forest virus (SFV) replicon have been widely studied as candidate vaccines. Following intramuscular injection, dispersal of the RNA occurs to the local lymph node only, ... -
Post-polyploidy evolution in yeasts
(Trinity College (Dublin, Ireland). Department of Genetics, 2007)Whole-genome duplication (WGD) and gene duplication are topics central to the study of genome evolution. With the availability of genome sequences for both paleopolyploid (post-WGD) and non-polyploid outgroup (pre-WGD) ... -
Functional characterisation of Arabidopsis genes encoding members of the AP2/ERF transcription factor family
(Trinity College (Dublin, Ireland). Department of Genetics, 2005)The EU Framework 5 REGIA (Regulatory Gene Initiative in Arabidopsis) Consortium, comprising 29 laboratories, was established to investigate transcription factor gene function in Arabidopsis. As part of the REGIA project, ... -
The essential YycFG two-component system controls cell wall metabolism in Bacillus subtilis
(Trinity College (Dublin, Ireland). Department of Genetics, 2008)The work presented in this thesis describes a comprehensive analysis of the YycFG two-com ponent system (TCS) in Bacillus subtilis. TCSs are widespread mechanisms used by bacteria to sense and respond to the prevailing ... -
The monocyte protein C pathway : implications in human diseases
(Trinity College (Dublin, Ireland). Department of Genetics, 2004)The protein C (PC) pathway provides an important link between the coagulation, fibrinolytic, and inflammatory pathways. PC/activated protein C (APC) is one o f very few therapies shown to effectively reduce the morbidity ... -
Characterization of peptide mimics to antigens chaperoned by Hsp70 in MDA-MB-231 breast tumour cells
(Trinity College (Dublin, Ireland). Department of Microbiology, 2005)Tumour-derived heat shock protein (Hsp) preparations have been shown to elicit anti-tumour immune responses in both mice and man. Analysis of Hsp preparations from tumour cells revealed that the immuno-protective property ... -
Exploration of RNAi-based therapeutic strategies for dominantly inherited disorders
(Trinity College (Dublin, Ireland). Department of Genetics, 2006)The primary aim of this thesis was to explore genetic agents with the ability to suppress expression of certain gene products i.e. those involved in the etiology of dominant disorders such as osteogenesis imperfecta (OI) ... -
Examining the role of the probiotic candidate Lactobacillus salivarius in intestinal and immune homeostasis
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Microbiology, 2019)A complex interplay exists between commensals of the gut microbiota, pathogenic bacteria and the host organism within the intestinal environment. The homeostasis of the intestinal epithelium and resident immune cells is ... -
Ancient Goat Genomics: Structure, Selection, and Admixture
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2019)The wild bezoar Capra aegagrus was brought under human control c. 8,000 BC, leading to the domestic goat Capra hircus. This livestock species remains in use 10,000 years later, and is of particular importance to communities ... -
Understanding the diverse roles of polycomb-like proteins in the regulation of chromatin and transcriptional landscapes
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2019)The Polycomb repressive complex 2 (PRC2) is a multiprotein chromatin modifying complex that is essential for vertebrate development and frequently deregulated in cancer. In higher eukaryotes, PRC2 is responsible for all ... -
Blood-retina barrier regulation and sterile inflammation in retinal homeostasis and disease
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2019)Age-related macular degeneration (AMD) is the leading cause of central vision loss and blindness in the elderly. It is caused by a progressive loss of photoreceptors in the macula, thought to occur secondary to the damage ...
