School of Genetics & Microbiology: Recent submissions
Now showing items 441-460 of 911
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Analysis of stage-specific gene perturbations and characterisation of two novel F-box genes during flower development in Arabidopsis thaliana
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2018)The model plant Arabidopsis thaliana has been used for past three decades to study the genetic and molecular processes underlying floral organogenesis. Flowers of this small plant consist of four concentric whorls, containing ... -
Primary open-angle glaucoma: on the development of novel therapeutic approaches
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2018)Glaucoma is one of the most prevalent forms of preventable blindness, affecting more than 60 million people worldwide. While normotensive forms of the disease do exist, the majority of cases are caused by elevations in ... -
Optimisation of therapies for inherited retinal and mitochondrial diseases
Inherited retinal degenerations (IRDs) are the most frequent cause of vision loss in people of working age. They have highly varied causes and pathophysiologies, and are typically incurable. Gene therapy has emerged as a ... -
The blood-brain barrier in neuropsychiatric disorders
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2018)Schizophrenia is a severe and disabling mental disorder that affects approximately 1% of the population. Such is the heterogeneous nature of the disease that genetic, neurobiological and environmental factors all contribute ... -
Motor axon guidance in Drosophila
(2019) -
Targeting the tight-junctions of the conventional outflow pathway in primary open-angle glaucoma.
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2018)Primary open-angle glaucoma (POAG) is one of the leading causes of blindness worldwide, affecting an estimated 44.1 million people (Tham et al. 2014). POAG is characterised by elevated intraocular pressure (IOP) due to ... -
Investigation of the PhoPR two-component signal transduction system in Bacillus subtilis, Staphylococcus aureus and Staphylococcus epidermidis
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2018)Investigation of the PhoPR two-component signal transduction system in Bacillus subtilis, Staphylococcus aureus and Staphylococcus epidermidis. Michael Prunty The PhoPR two-component signal transduction system (TCS) ... -
Fibrinogen activates the capture of human plasminogen by staphylococcal fibronectin-binding proteins
(2017)Invasive bacterial pathogens can capture host plasminogen (Plg) and al- low it to form plasmin. This process is of medical importance as surface-bound plas- min promotes bacterial spread by cleaving tissue components and ...
