School of Genetics & Microbiology: Recent submissions
Now showing items 461-480 of 911
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Tight junctions of blood-brain barrier in Alzheimer's disease
(Trinity College (Dublin, Ireland). Department of Genetics, 2015)Located along the brain endothelium, the blood-brain barrier (BBB) is essential for regulating the exchange of ions and macromolecules between the blood circulation and neural tissue and restricting brain entry of potentially ... -
Inflammatory consequences of divergent cell death signals
(Trinity College (Dublin, Ireland). Department of Genetics, 2015)Tumor Necrosis Factor (TNF) is an apical cytokine that drives inflammation through triggering the synthesis and secretion of multiple downstream pro-inflammatory cytokines and chemokines. Generally, TNF stimulation does ... -
MicroRNA-21 Limits Uptake of Listeria monocytogenes by Macrophages to Reduce the Intracellular Niche and Control Infection.
(2017)MiRNAs are important post-transcriptional regulators of gene expression. MiRNA expression is a crucial part of host responses to bacterial infection, however there is limited knowledge of their impact on the outcome of ... -
Persistent, ancient constraints shape copy number and expression variation of dosage-sensitive genes
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2017) -
Control of floral meristem activity in the model plant Arabidopsis thaliana
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2017)Over the past 30 years, the flower development has been one of the main model to study the genetic control of organogenesis in higher plants. The work on Arabidopsis thaliana has led to the proposal of the ABC model of ... -
Investigating transcription and the histone methylation landscape in quiescent cells of Saccharomyces cerevisiae
(Trinity College (Dublin, Ireland). Department of Microbiology, 2015)Eukaryotic genomes are organised as the DNA-protein complex, chromatin within the cell nucleus. The fundamental subunit of chromatin is the nucleosome, which comprises 146 base pairs of DNA wrapped around an octamer of ... -
MicroRNA regulation of the bovine alveolar macrophage response to Mycobacterium bovis
(Trinity College (Dublin, Ireland). Department of Genetics, 2015)Bovine tuberculosis is one of the most economically significant infectious diseases of cattle in Ireland and globally, resulting in economic losses of approximately €2 billion annually. The causative agent is Mycobacterium ... -
Genetics of calving performance
(Trinity College (Dublin, Ireland). Department of Genetics, 2015)Calving performance is a significant contributor to the profitability of cattle production systems whilst also becoming an increasingly important welfare issue in recent years. Calving performance includes both dystocia ... -
Sterile inflammation and age-related macular degeneration
(Trinity College (Dublin, Ireland). Department of Genetics, 2015)Age-related macular degeneration (AMD) is the leading cause of legal blindness in elderly individuals in the developed world, estimated to affect 196 million people worldwide by 2020 (Wong et ai, 2014). AMD primarily affects ... -
Modulating oxidative stress in the retina using gene therapy as a potential treatment for inherited retinopathies
(Trinity College (Dublin, Ireland). Department of Genetics, 2014)The focus of this thesis was the exploration of genetic modulators of oxidative stress in transgenic mouse models of Retinitis Pigmentosa (RP). This disease can be inherited both dominantly and recessively and can be either ... -
Analysis of the function of the N1 subdomain of MSCRAMMs of Staphylococcus aureus
(Trinity College (Dublin, Ireland). Department of Microbiology, 2014)The Microbial Surface Component Recognising Adhesive Matrix Molecules (MSCRAMMs) family of cell wall-associated proteins have recently been reclassified based on structure-function analysis. Under this new regime the MSCRAMM ... -
Biomass to biofuel : the engineering of Saccharomyces species for the co-fermentation of cellulose and xylose
(Trinity College (Dublin, Ireland). Department of Microbiology, 2015)Lignocellulose represents one of the most abundant biomass sources in the world. Its renewable and abundant nature makes it a prime target for use in bioethanol production. The efficient conversion of lignocellulosic biomass ... -
Reverse signaling by semaphorin-6A regulates cellular aggregation and neuronal morphology
(2016)The transmembrane semaphorin, Sema6A, has important roles in axon guidance, cell migration and neuronal connectivity in multiple regions of the nervous system, mediated by context-dependent interactions with plexin receptors, ... -
A genome-wide resource for the analysis of protein localisation in Drosophila
(2016)The Drosophila genome contains >13000 protein-coding genes, the majority of which remain poorly investigated. Important reasons include the lack of antibodies or reporter constructs to visualise these proteins. Here, we ... -
The genetics of amyotrophic lateral sclerosis
(Trinity College (Dublin, Ireland). Department of Genetics, 2013)Amyotrophic lateral sclerosis, commonly referred to as motor neuron disease or simply ALS, is a neurological disorder which involves the degeneration of upper and lower motor neurons. The disease is associated with a ... -
The interplay between cell death and inflammation
(Trinity College (Dublin, Ireland). Department of Genetics, 2015)The connection between cell death and inflammation is an ancient one, first documented in the first century AD by the roman physician Galen. Cell death, as a consequence of tissue injury or infection, is a potent and ... -
High-throughput investigation of virulence gene regulation by sRNAs in Salmonella Typhimurium
(Trinity College (Dublin, Ireland). Department of Microbiology, 2015)This study focused on novel gene regulatory systems in Salmonella enterics serovar Typhimurium, a model gram-negative, bacterial pathogen. The sRNA-mediated control of virulence genes was a particular emphasis. The research ... -
The Chromodomain Helicase DNA binding protein CHD5 is required for neuronal differentiation and repression of non neuronal genes
(Trinity College (Dublin, Ireland). Department of Genetics, 2012)The candidate tumour suppressor gene chromodomain, helicase DNA-binding protein 5 (CHD5) is frequently deleted in neuroblastoma. However, little is known about the role of the CHD5 protein during normal development or its ...
