Surgery: Recent submissions
Now showing items 101-120 of 185
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Malnutrition, deficiency, and nutritional practice in patients with acute and chronic pancreatitis
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2014)Pancreatitis is an inflammatory disease of the pancreas and it may occur in either acute or chronic form, the former being life-threatening in its most severe form, and the latter being a progressive, irreversible disease ... -
Visceral adiposity and oesophageal adenocarcinoma : exploring the role of the insulin like-growth factor axis
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2012)In the modem era there is a consistent reported trend of markedly improved operative and oncologic outcomes from high-volume oesophageal programmes within academic medical centres. The current benchmark survival rate in ... -
Capacity - A quart into a pint pot?
(2016) -
Nutritional studies in upper gastrointestinal cancer
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2008)Carcinoma of the oesophagus, gastro-oesophageal junction and stomach represent aggressive diseases with a poor prognosis even in patients undergoing curative resection. Where squamous cell histology once predominated, the ... -
Gastro-oesophageal reflux disease : studies in physiology and innovations in surgical management
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2007)The work detailed in this thesis combined studies in surgical audit with assessment of outcomes relating to dysmotility, evaluated an innovative approach to quality assurance in surgery, explored new understandings of ... -
Predictors of response of rectal cancer to neoadjuvant radiochemotherapy
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2007)Rectal cancers staged as cT3/T4 +/- node positive routinely receive neoadjuvant radiochemotherapy (RCT) followed by total mesorectal excision (TME). By this approach tumours can be both downstaged and downsized resulting ... -
The effect of major surgery on systemic and splanchnic immune function : examining the two-hit and gut hypotheses of the systemic inflammatory response syndrome
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2006)The systemic inflammatory response syndrome (SIRS), sepsis and multiple organ dysfunction syndrome (MODS) are recognized sequelae of complex major surgery and underlie significant morbidity and mortality. The systemic ... -
Pelvic floor dysfunction : its assessment by MRI and strength duration test and its response to biofeedback
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2006)The component features of pelvic floor dysfunction (PFD) are interrelated but the development of a unified strategy to investigate and treat these problems has been slow; this has invariably affected the outcome of available ... -
Systemic inflammation after cardiac surgery
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2008)Genetically determined inter-individual variation in cytokine production, influences outcome in patients with systemic inflammation and severe sepsis. However outcome in patients with sepsis is also dependant on the presence ... -
Experimental reinforcement of the vertebral endplate : a biomechanical study on prevention of intervertebral cage subsidence
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2007) -
Defining a successful esophagectomy.
(2014) -
Eosinophilic ascites with marked peripheral eosinophilia: a diagnostic challenge.
(2014)Eosinophilic disease of the gastrointestinal tract is rare and is characterized by the presence of gastrointestinal symptoms in association with eosinophilic infiltration of any part of the gastrointestinal tract. Clinical ... -
Leptin and adiponectin receptor expression in oesophageal cancer.
(2014)BACKGROUND: Oesophageal adenocarcinoma is an exemplar model of an obesity-associated adenocarcinoma. Altered secretion of adipokines by visceral fat is believed to play a key role in tumorigenesis. This study examined ... -
The mTOR pathway in obesity driven gastrointestinal cancers: Potential targets and clinical trials.
(2016)The mechanistic target of rapamycin (mTOR) is a crucial point of convergence between growth factor signalling, metabolism, nutrient status and cellular proliferation. The mTOR pathway is heavily implicated in the progression ... -
Prognostic significance of neuroepithelial transforming gene 1 in adenocarcinoma of the oesophagogastric junction.
(2014)BACKGROUND: Neuroepithelial transforming gene 1 (NET1) mediates tumour invasion and metastasis in a number of cancers, including gastric adenocarcinoma. It is an indicator of poor prognosis in breast cancer and glioma. ... -
The role of energy metabolism in driving disease progression in inflammatory, hypoxic and angiogenic environments
(2015)Cellular metabolism plays a crucial role in primed inflammatory, hypoxic and an - giogenic microenvironments by supporting disease progression in a range of disease entities. To adapt to fluctuating st ... -
The role of inflammation in cancer of the esophagus.
(2014)Esophageal adenocarcinoma is the eighth most common malignancy worldwide. The overall prognosis is poor, with 5-year survival ranges of approximately 15-25%, and 30-50% for patients who can be treated with curative intent. ...
