Surgery: Recent submissions
Now showing items 81-100 of 185
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Anti-cancer effects of baicalein in non-small cell lung cancer in-vitro and in-vivo
(2016)Background Baicalein is a widely used Chinese herbal medicine derived from Scutellaria baicalenesis, which has been traditionally used as anti-inflammatory and anti-cancer therapy. In this study we examined the anti-tumour ... -
Ischaemic stroke or TIA in older subjects associated with impaired dynamic blood pressure control in the absence of severe large artery stenosis.
(2015)Background: older subjects may require higher baseline blood pressures to maintain cerebral perfusion. We investigated whether episodic hypotension is associated with tissue infarction in subjects with syncopal symptoms ... -
Gene expression profiling in patients with severe sepsis
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2014)The human response to infection ranges from mild illness which is relatively well tolerated to a severe, potentially life-threatening syndrome termed severe sepsis. This thesis explored this response in patients hospitalised ... -
Golgi phosphoprotein 2 (GOLPH2) is a novel bile acid-responsive modulator of oesophageal cell migration and invasion
(2015)Background: The aetiology of Barrett’s oesophagus (BO) and oesophageal cancer is poorly understood. We previously demonstrated that Golgi structure and function is altered in oesophageal cancer cells. A Golgi-associated ... -
LC3B globular structures correlate with survival in esophageal adenocarcinoma
(2015)Background Esophageal adenocarcinoma has the fastest growing incidence of any solid tumor in the Western world. Prognosis remains poor with overall five-year survival rates under 25 %. Only a limited number of patients ... -
MicroRNA-330-5p as a putative modulator of neoadjuvant chemoradiotherapy sensitivity in oesophageal adenocarcinoma
(2015)Oesophageal adenocarcinoma (OAC) is the sixth most common cause of cancer deaths worldwide, and the 5-year survival rate for patients diagnosed with the disease is approximately 17%. The standard of care for locally advanced ... -
Pancreatic anastomosis after pancreatoduodenectomy: A position statement by the International Study Group of Pancreatic Surgery (ISGPS)
(2016)Clinically relevant postoperative pancreatic fistula (grades B and C of the ISGPS definition) remains the most troublesome complication after pancreatoduodenectomy. The approach to management of the pancreatic remnant via ... -
Postoperative exercise training is associated with reduced respiratory infection rates and early discharge: A case-control study
(2015)Introduction Pulmonary complications are a significant cause of morbidity, mortality and increased hospital stay following complex abdominal surgery. We investigated whether postoperative early aerobic activity with a ... -
The cost-effectiveness of radiofrequency ablation for Barrett's esophagus with low-grade dysplasia: Results from a randomized controlled trial (SURF trial)
(2016)Background and Aims The Surveillance versus Radiofrequency Ablation (SURF) trial randomized 136 patients with Barrett's esophagus (BE) containing low-grade dysplasia (LGD), to receive radiofrequency ablation (ablation, ... -
Changes in mitochondrial stability during the progression of the Barrett's esophagus disease sequence
(2016)Background Barrett’s esophagus follows the classic step-wise progression of metaplasia-dysplasia-adenocarcinoma. While Barrett’s esophagus is a leading known risk factor for esophageal adenocarcinoma, the pathogenesis ... -
Cytokine mRNA gene expression profiles in human host response to infection and sepis
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2013)This thesis explores the hypothesis that a cytokine mediated immune response modulates the human immune response to infection. Attenuation of this cytokine response may increase the risk of infection and sepsis in humans. -
The role of the cyclooxygenase-2 - prostaglandin E2 cascade in pancreatic cancer associated angiogenesis
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2010)Medical therapy has failed to make any significant impact on survival in pancreatic cancer. Non Steroidal Anti-inflammatory Drugs (NSAIDs) have shown promise in several gastrointestinal (Gl) cancers. Evidence has suggested ... -
Local and systemic inflammation in oesophageal disease
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2010)Background: Reflux-induced injury and oxidative stress result in oesophageal inflammation and the potential for progression to intestinal metaplasia and adenocarcinoma. Proton-pump inhibitors represent the standard medical ... -
Obesity and cancer
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2011)Cancer rates are increasing with predictions of incidence rates doubling between 2000 and 2020. Although several factors are contributory, the rising incidence of overweight and obesity is currently thought to be fuelling ... -
Molecular and radiological prediction of response to neo-adjuvant chemoradiation in patients with oesophageal cancer
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2009)The initial phase of the project’s laboratory component involved optimising techniques that would become necessary when analysing fresh oesophageal tissue. There are a number of commercially available techniques for tissue ... -
Extending the limits of cardiovascular disease risk estimation : the roles of HDL cholesterol, resting heart rate and advancing years
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2010)Background: Atherosclerotic cardiovascular diseases (CVD) including coronary heart disease, stroke and peripheral vascular disease are the commonest causes of death Worldwide. The underlying atherosclerosis starts early ... -
Delineating the pro-carcinogenic pathways activated by obesity in Barrett's oesophagus
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2011)Incidences of obesity in the developed world represent a worrying epidemic. Obesity is associated with increased rates of diabetes, cardiovascular disease and cancer. Oesophageal adenocarcinoma rates have increased in the ... -
Investigation of the link between obesity and breast cancer - the role of adipose tissue in the development and propagation of malignancy
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2010)Obesity and the metabolic syndrome are emerging risk factors for breast cancer. They are associated with increased incidence, an increased recurrence rate and a poorer prognosis. Despite this epidemiological evidence to ... -
Oesophageal inflammation and tumourigenesis - inherited variation in an Irish population
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2010)Cancer is a major medical challenge of this era and early diagnosis of cancer is critical to curative therapy. The search for biomarkers that may indicate the risk or presence of cancer is ongoing in thousands of laboratories ... -
Molecular interactions in obesity and cancer
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2010)The incidence of overweight and obesity has reached pandemic proportions in modern society, affecting two thirds of the US and over half of the European population. Obesity is associated with increased morbidity and mortality ...
