Surgery: Recent submissions
Now showing items 41-60 of 185
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Leukaemia inhibitory factor is associated with treatment resistance in oesophageal adenocarcinoma.
(2018)Oesophageal cancer is an aggressive disease with a poor 5 year survival rate of <20% of diagnosed patients. Unfortunately, only 20-30% Oesophageal Adenocarinoma (OAC) patients show a beneficial response to neoadjuvant ... -
Tumour vasculature immaturity, oxidative damage and systemic inflammation stratify survival of colorectal cancer patients on bevacizumab treatment
(2018)Despite treatment of patients with metastatic colorectal cancer (mCRC) with bevacizumab plus chemotherapy, response rates are modest and there are no biomarkers available that will predict response. The aim of this study ... -
Measuring the impact of oesophagectomy on physical functioning and physical activity participation: a prospective study
(2019)Background: Oesophagectomy remains the only curative intervention for oesophageal cancer, with defined nutritional and health-related quality of life (HR-QOL) consequences. It follows therefore that there is a significant ... -
1,4-dihydroxy quininib attenuates growth of colorectal cancer cells and xenografts and regulates the TIE-2 signaling pathway in patient tumours
(2019)Colorectal cancer (CRC) is the second leading cause of cancer associated deaths in developed countries. Cancer progression and metastatic spread is reliant on new blood vasculature, or angiogenesis. Tumour-related angiogenesis ... -
Mucosal-Associated Invariant T Cells Display Diminished Effector Capacity in Oesophageal Adenocarcinoma
(2019)Oesophageal adenocarcinoma (OAC) is an aggressive malignancy with poor prognosis, and incidence is increasing rapidly in the Western world. Mucosal-associated invariant T (MAIT) cells recognize bacterial metabolites and ... -
Visceral Adipose Tissue Modulates Radiosensitivity in Oesophageal Adenocarcinoma.
(2019)Oesophageal adenocarcinoma (OAC) is an exemplar model of obesity-associated cancer. Response to neoadjuvant chemoradiotherapy (NA CRT) is a clinical challenge. We examined if visceral adipose tissue and obesity ... -
Editorial: T cell alterations in adipose tissue during obesity, HIV, and cancer
(Frontiers Media, 2019-05-28)This collection of articles is designed to foster understanding of the variety and function of T cells in adipose from different species in different disease states. This work originally developed from the obesity epidemic. ... -
Immunotoxicity Considerations for Next Generation Cancer Nanomedicines
(2019)Although interest and funding in nanotechnology for oncological applications is thriving, translating these novel therapeutics through the earliest stages of preclinical assessment remains challenging. Upon intravenous ... -
Single-stage approach for the management of choledocolithiasis with concomitant cholelithiasis. Implementation of a protocol in a secondary hospital
(2019)Background: Current evidence shows that single-stage treatment of concomitant choledocholithiasis and cholelithiasis is as effective and safe as two-stage treatment. However, several studies suggest that single-stage ... -
Distribution of lymph node metastases in esophageal carcinoma [TIGER study]: Study protocol of a multinational observational study
(BMC, 2019)Background: An important parameter for survival in patients with esophageal carcinoma is lymph node status. The distribution of lymph node metastases depends on tumor characteristics such as tumor location, histology, ... -
A comparative quantitative LC-MS/MS profiling analysis of human pancreatic adenocarcinoma, adjacent-normal tissue, and patient-derived tumour xenografts
(2018)Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers worldwide; it develops in a relatively symptom-free manner, leading to rapid disease progression and metastasis, leading to a 5-year survival rate of ... -
Enhancing treatment response to neo-adjuvant radiation therapy in oesophageal cancer using novel dual action drugs targeting tumour energy metabolism and angiogenesis
(Trinity College Dublin. School of Medicine. Discipline of Surgery, 2019)Oesophageal cancer is an aggressive malignancy associated with a poor 5-year survival of <20%, accounting for over 400,000 deaths each year. The current standard of care for oesophageal adenocarcinoma (OAC) ... -
National Standards for Provision and Outcomes in Adult and Paediatric Burn Care
(2018)The ‘National Standards for Provision and Outcomes in Adult and Paediatric Burn Care’ presented here are the result of a collaboration between the British Burn Association (BBA) and the burn care Operational Delivery ... -
Investigation of the molecular mechanisms underlying radioresistance in oesophageal cancer
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2011)The current standard of care for oesophageal cancer in Ireland involves neoadjuvant chemoradiation therapy (CRT) followed by surgery. Despite advances in treatment, resistance to neoadjuvant CRT remains a significant ... -
The Epidemiological, Clinical and Genetic Aspects of Chronic Pancreatitis in Ireland
(Trinity College Dublin. School of Medicine. Discipline of Surgery, 2018)Abstract: The epidemiological, clinical and genetic aspects of chronic pancreatitis in Ireland - Hazel Maria Ní Chonchubhair. Introduction: Chronic pancreatitis is a progressive, inflammatory, malabsorptive disease of the ...
