Surgery: Recent submissions
Now showing items 61-80 of 185
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Investigation into mitochondrial function and energy metabolism and their connectivity with protumourigenic cellular proceses in Barrett's oesophagus
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2016)Contemporary clinical management of Barrett’s oesophagus has highlighted the lack of accurate predictors of neoplastic progression. Currently all Barrett’s patients undergo surveillance, however, only a subset of patients ... -
Continuous Vagal Intraoperative Monitoring Prevents Recurrent Laryngeal Nerve Paralysis by Revealing Initial EMG Changes of Impending Neuropraxic Injury
The larynx is the phonating mechanism, specifically designed for voice production. Through movement of the cartilages, the larynx varies the opening between the vocal cords and thereby varies the pitch of sounds produced ... -
Expanding the role of positron emission tomography-computed tomography and its utility in the management of oesophageal cancer
(Trinity College Dublin. School of Medicine. Discipline of Surgery, 2018)Purpose: 18F-fluorodeoxyglucose positron emission tomography and computed tomography (18F-FDG PET-CT) is an established diagnostic tool in the management of oesophageal cancer. The role of 18F-FDG PET-CT in assessing tumour ... -
Molecular analysis of cell proliferation and apoptosis in oesophageal adenocarcinoma
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2002)Cancer of the oesophagus is a particularly virulent gastrointestinal malignancy with poor prognosis. Replacement of the nomial squamous epithelium of the oesophagus with columnar epithelium (Barrett’s oesophagus) as a ... -
The immunomodulatory chemokine CCL28 in oesophageal disease progression
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2014)Barrett’s oesophagus (BO) develops in response to bile acid reflux and confers increased risk of progression to oesophageal adenocarcinoma (OAC). During this disease progression, the immune microenvironment of the oesophageal ... -
Mitochondrial dysfunction during disease progression in Barrett's oesophagus
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2014)Barrett’s oesophagus is the leading risk factor for oesophageal adenocarcinoma. However, it is difficult to identify patients at risk of disease progression. Mitochondria are highly susceptible to mutations due to high ... -
Mechanisms linking obesity, genomic instability and the radioresponse in oesophageal adenocarcinoma
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2014)The increasing incidence of oesophageal adenocarcinoma (OAC) parallels the rapidly rising incidence of obesity. OAC is an exemplar model of obesity-associated cancer, with an increasing focus on the role of visceral adipose ... -
Protein Kinase C Beta II suppresses colorectal cancer by regulating IGF-1 mediated cell survival
(2016)Despite extensive efforts, cancer therapies directed at the Protein Kinase C (PKC) family of serine/threonine kinases have failed in clinical trials. These therapies have been directed at inhibiting PKC and have, in some ... -
Preclinical validation of the small molecule drug quininib as a novel therapeutic for colorectal cancer
(2016)Colorectal cancer (CRC) is a leading cause of cancer deaths. Molecularly targeted therapies (e.g. bevacizumab) have improved survival rates but drug resistance ultimately develops and newer therapies are required. We ...
