dc.contributor.author | FALLON, PADRAIC | |
dc.date.accessioned | 2009-09-17T17:09:23Z | |
dc.date.available | 2009-09-17T17:09:23Z | |
dc.date.issued | 2007 | |
dc.date.submitted | 2007 | en |
dc.identifier.citation | Smith, P., Mangan, N.E., Walsh, C.M, Fallon, R.E., van Rooijen, N., McKenzie, & Fallon, P.G. `Infection with a helminth parasite prevents experimental colitis via a macrophage-mediated mechanism? in Journal of Immunology, 178, 2007, pp 4557 - 4566 | en |
dc.identifier.other | Y | |
dc.description | PUBLISHED | en |
dc.description.abstract | The propensity of a range of parasitic helminths to stimulate a Th2 or regulatory cell-biased response has been proposed to reduce the severity of experimental inflammatory bowel disease. We examined whether infection with Schistosoma mansoni, a trematode parasite, altered the susceptibility of mice to colitis induced by dextran sodium sulfate (DSS). Mice infected with schistosome worms were refractory to DSS-induced colitis. Egg-laying schistosome infections or injection of eggs did not render mice resistant to colitis induced by DSS. Schistosome worm infections prevent colitis by a novel mechanism dependent on macrophages, and not by simple modulation of Th2 responses, or via induction of regulatory CD4+ or CD25+ cells, IL-10, or TGF-. Infected mice had marked infiltration of macrophages (F4/80+CD11b+CD11c?) into the colon lamina propria and protection from DSS-induced colitis was shown to be macrophage dependent. Resistance from colitis was not due to alternatively activated macrophages. Transfer of colon lamina propria F4/80+ macrophages isolated from worm-infected mice induced significant protection from colitis in recipient mice treated with DSS. Therefore, we propose a new mechanism whereby a parasitic worm suppresses DSS-induced colitis via a novel colon-infiltrating macrophage population. | en |
dc.description.sponsorship | The Wellcome Trust, Science Foundation Ireland, and the Higher Education Authority Programme for Research in Third Level Institutions | en |
dc.format.extent | 4557 | en |
dc.format.extent | 4566 | en |
dc.format.extent | 991979 bytes | |
dc.format.mimetype | application/pdf | |
dc.language.iso | en | en |
dc.publisher | The American Association of Immunologists | en |
dc.relation.ispartofseries | Journal of Immunology | en |
dc.relation.ispartofseries | 178 | en |
dc.rights | Y | en |
dc.subject | Clinical Medicine | en |
dc.title | Infection with a helminth parasite prevents experimental colitis via a macrophage-mediated mechanism. | en |
dc.type | Journal Article | en |
dc.type.supercollection | scholarly_publications | en |
dc.type.supercollection | refereed_publications | en |
dc.identifier.peoplefinderurl | http://people.tcd.ie/pfallon | |
dc.contributor.sponsor | Wellcome Trust | |
dc.contributor.sponsor | Science Foundation Ireland | |
dc.contributor.sponsor | Higher Education Authority | |
dc.identifier.uri | http://hdl.handle.net/2262/32909 | |