Show simple item record

A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21

dc.contributor.authorMc Manus, Rossen
dc.contributor.authorFeighery, Conlethen
dc.contributor.authorKelleher, Dermoten
dc.date.accessioned2009-10-07T10:07:18Z
dc.date.available2009-10-07T10:07:18Z
dc.date.issued2007en
dc.date.submitted2007en
dc.identifier.citationvan Heel DA, Franke L, Hunt KA, Gwilliam R, Zhernakova A, Inouye M, Wapenaar MC, Barnardo MC, Bethel G, Holmes GK, Feighery C, Jewell D, Kelleher D, Kumar P, Travis S, Walters JR, Sanders DS, Howdle P, Swift J, Playford RJ, McLaren WM, Mearin ML, Mulder CJ, McManus R, McGinnis R, Cardon LR,, A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21., Nature Genetics, 39, 7, 2007, 827, 829en
dc.identifier.otherYen
dc.descriptionPUBLISHEDen
dc.descriptionPMID: 17558408en
dc.description.abstractWe tested 310,605 single-nucleotide polymorphisms for association in 778 celiac disease cases and 1422 controls. Outside the HLA, the most significant finding (rs13119723, P=2.0 ? 10?7, empirical genome-wide significance P=0.045) was in the KIAA1109/Tenr/IL2/IL21 linkage disequilibrium block. Association was independently confirmed in two further collections (strongest at rs6822844, 24kB 5' of IL21, meta-analysis P=1.3 ? 10?14, OR 0.63), suggesting genetic variation in this region predisposes to celiac disease.en
dc.description.sponsorshipWe acknowledge funding from Coeliac UK; the Coeliac Disease Consortium (an innovative cluster approved by the Netherlands Genomics Initiative and partly funded by the Dutch Government, grant BSIK03009); the Netherlands Genomics Initiative (grant 050-72-425); the Netherlands Organization for Scientific Research (grant 901-04-219); the Science Foundation Ireland and the Wellcome Trust (GR068094MA Clinician Scientist Fellowship to D.A.vH; New Blood Fellowship to R.M.; support for the work of R.McG and P.D.). The authors acknowledge use of DNA from the British 1958 Birth Cohort collection, funded by the UK Medical Research Council grant G0000934 and the Wellcome Trust grant 068545/Z/02.en
dc.format.extent827en
dc.format.extent829en
dc.format.mimetypeapplication/pdf
dc.language.isoenen
dc.relation.ispartofseriesNature Geneticsen
dc.relation.ispartofseries39en
dc.relation.ispartofseries7en
dc.rightsYen
dc.subjectClinical Medicineen
dc.titleA genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21en
dc.typeJournal Articleen
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/rmcmanusen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/cfigheryen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/kellehdpen
dc.identifier.rssinternalid46306en
dc.identifier.doihttp://dx.doi.org/10.1038/ng2058en
dc.subject.TCDThemeGenes & Societyen
dc.subject.TCDThemeImmunology, Inflammation & Infectionen
dc.subject.TCDThemeInternational Developmenten
dc.identifier.rssurihttp://dx.doi.org/0.1038/ng2058
dc.identifier.urihttp://hdl.handle.net/2262/33807


Files in this item

Thumbnail
Name:
A genome-wide association study ...
Size:
632.7Kb
Format:
PDF
Description:
published (publisher copy) ...
View/Open
Thumbnail
Name:
license.txt
Size:
3.321Kb
Format:
Text file
View/Open

This item appears in the following Collection(s)

Show simple item record