Physiology: Recent submissions
Now showing items 141-160 of 246
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An investigation of the molecular signalling events which occur in cannabiniod-mediated neuronal apoptosis
(Trinity College (Dublin, Ireland). Department of Physiology, 2008)The plant-derived cannabinoid Δ9-Tetrahydrocannabinol, is the predominant psychoactive moiety of cannabis and exerts a variety of psychological and physiological effects in humans. Previous investigations in this laboratory ... -
A study of neuroinflammation in a mouse model of Alzheimer's disease
(Trinity College (Dublin, Ireland). Department of Physiology, 2010)Microglia are the principal immune-competent cell of the central nervous system (CNS) and there is evidence to suggest microglia are the co-ordinating cells of the CNS inflammatory response. The blood brain barrier (BBB) ... -
An investigation into the cellular and molecular signalling events which occur in [Beta]-amyloid-treated cultured cortical neurons
(Trinity College (Dublin, Ireland). Department of Physiology, 2004)Deposition of β-amyloid around neurons is a neuropathological hallmark of Alzheimer’s disease. The aim of this study was to investigate the cellular and molecular mechanisms underlying β-amyloid-mediated cell death in ... -
An investigation of age-related changes in the brain and the neuroprotective effects of the omega-3 fatty acids docosapentaenoic acid and eicosapentaenoic acid
(Trinity College (Dublin, Ireland). Department of Physiology, 2009)The data presented here indicate that the n-3 polyunsaturated fatty acid docosapentaenoic acid (DPA), a metabolite of eicosapentaenoic acid (bPA), possesses neuroprotective and anti-inflammatory properties. Previous evidence ... -
The impact of hypoxia and cannabinoids on the differentiation of adult rat mesenchymal stem cells in bone and cartilage tissue engineering
(Trinity College (Dublin, Ireland). Department of Physiology, 2009)Adult mesenchymal stem cells (MSCs) have the potential to self-renew and differentiate into cartilage, bone, muscle and fat. This subset of bone marrow stromal cells therefore holds great potential for tissue engineering ... -
The effect of neuronal insult on neurotrophin receptor expression and signalling
(Trinity College (Dublin, Ireland). Department of Physiology, 2007)The neurotrophins were initially identified as a group of target-derived neuronal factors but have since been shown to mediate a wide range of biological functions including cell survival, maintenance, differentiation and ... -
A study of the potential of adult mesenchymal stem cells in bone and cartilage tissue engineering
(Trinity College (Dublin, Ireland). Department of Physiology, 2006)Adult mesenchymal stem cells (MSCs) have the potential to self-renew and differentiate into bone, cartilage, fat and muscle cells. This cell population offers significant potential for engineering of musculoskeletal tissue. ... -
An investigation of the effect of Tetrahydrocannabinol on the viability of cortical neurons
(Trinity College (Dublin, Ireland). Department of Physiology, 2005)Δ9-Tetrahydrocannabinol (THC), the principle psychoactive component of marijuana (Cannabis sativa), elicits diverse psychological effects in humans. THC exerts its central effects through the CB1 cannabinoid receptor, a ... -
Does IL-1F5 have anti-inflammatory actions in the brain?
(Trinity College (Dublin, Ireland). Department of Physiology, 2007)Similarity in structure and sequence homology has led to the identification of additional members of the IL-1 ligand and receptor superfamilies. Because of the importance of IL-1 in immune and inflammatory reactions, ... -
Modulation of inflammatory changes in the rat hippocampus by atorvastatin
(Trinity College (Dublin, Ireland). Department of Physiology, 2007)Inflammatory changes, typified by an increase in pro-inflammatory cytokine production and upregulation of corresponding signalling pathways, have been consistently shown in the brain of aged animals and animals treated ... -
Methylenenedioxymethamphetamine (MDMA Ecstasy) suppresses the innate immune system : a critical role for the anti-inflammatory cytokine interleukin-10
(Trinity College (Dublin, Ireland). Department of Physiology, 2007)3,4-methylenedioxymethamphetamine (MDMA; “Ecstasy”) is a ring-substituted phenylisopropylamine and globally abused drug that has been implicated to have immunosuppressive effects in animals and humans. Here MDMA was shown ... -
Carbohydrate versus caffeinated-carbohydrate beverages: effects on exercise performance and hydration status at rest and during exercise
(Trinity College (Dublin, Ireland). Department of Physiology, 2007)Carbohydrate versus caffeinated-carbohydrate beverages: effects on exercise performance and hydration status at rest and during exercise. The consumption of sports drinks to enhance athletic performance had been the subject ... -
Effect of the beta₂-adrenoceptor agonist clenbuterol on inflammatory signalling in the CNS and behaviour
(Trinity College (Dublin, Ireland). Department of Physiology, 2012)This thesis explored the anti-inflammatory and neuroprotective properties elicited by stimulation of the noradrenergic receptor, the P2-adrenoceptor, in the rat brain. Neuroinflammation is a feature of many chronic ... -
Long-term culture of pluripotent stem-cell-derived human neurons on diamonds" A substrate for neurodegeneration research and therapy
(2015)Brain Computer Interfaces (BCI) currently represent a field of intense research aimed both at understanding neural circuit physiology and at providing functional therapy for traumatic or degenerative neurological conditions. ... -
The protein interacting with C-kinase (PICK1) interacts with and attenuates parkin-associated endothelial-like (PAEL) receptor-mediated cell deat
(2014)The parkin-associated endothelial-like receptor (PAELR, GPR37) is an orphan G protein-coupled receptor that interacts with and is degraded by parkin-mediated ubiquitination. Mutations in parkin are thought to result in ... -
Modulation of intestinal microbiota by the probiotic VSL#3 resets brain gene expression and ameliorates the age-related deficit in LTP.
(2014)The intestinal microbiota is increasingly recognized as a complex signaling network that impacts on many systems beyond the enteric system modulating, among others, cognitive functions including learning, memory and ...
