Physiology: Recent submissions
Now showing items 201-220 of 246
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Rosiglitazone improves spatial memory and decreases insoluble A?(1-42) in APP/PS1 mice.
(2012)Identifying potential novel treatments for patients with Alzheimer?s disease (AD) is a major challenge and drugs used for other indications, particularly if they have anti- inflammatory properties, are particularly ... -
Rosiglitazone attenuates the age-related changes in astrocytosis and the deficit in LTP.
(2012)Neuroinflammation is a significant and consistent feature of many neurodegenerative disorders, including Alzheimer?s disease (AD) and Parkinson?s disease (PD). The greatest risk factor for neurodegenerative disorders is ... -
Toll-like receptor 3 activation modulates hippocampal network excitability, via glial production of interferon-β
(2013)The family of toll-like receptors (TLR) plays a major role in innate immunity due to their pathogen-recognition abilities. TLR3 is a sensor for double-stranded RNA, and regulates host-defense responses to several viruses, ... -
Age-related changes in the hippocampus (loss of synaptophysin and glial-synaptic interaction) are modified by systemic treatment with an NCAM-derived peptide, FGL
(2012)Altered synaptic morphology, progressive loss of synapses and glial (astrocyte and microglial) cell activation are considered as characteristic hallmarks of ageing. Recent evidence suggests that there is a concomitant ... -
CD200 fusion protein decreases microglial activation in the hippocampus of aged rats
(2012)The glycoprotein, CD200, is primarily expressed on neurons and its cognate receptor CD200R is expressed principally on cells of the myeloid lineage, including microglia. The interaction of CD200 with its receptor plays a ... -
The impact of aging on the brain - risk, resilience and repair
(2012)This Brief Commentary describes a Special Issue that features a series of papers that provide new data on how aging and inflammation interact to affect behaviors that are regulated by the dialogue between the immune system ... -
Adenosine A(2A) receptors control neuroinflammation and consequent hippocampal neuronal dysfunction.
(2011)The blockade of adenosine A2A receptors (A2AR) affords a robust neuroprotection in different noxious brain conditions. However, the mechanisms underlying this general neuroprotection are unknown. One possible mechanism ... -
Pharmacological inhibition of endocannabinoid degradation modulates the expression of inflammatory mediators in the hypothalamus following an immunological stressor
(2012)The endocannabinoid system is an important regulator of the nervous, neuroendocrine and immune systems, thus representing a novel therapeutic target for stress-related neuroinflammatory and psychiatric disorders. However, ... -
Effect of body tilt angle on fatigue and EMG activities in lower limbs during cycling
(2010)This study compared the rate of fatigue and lower limb EMG activities during high-intensity constantload cycling in upright and supine postures. Eleven active males performed seven cycling exercise tests: one upright graded ... -
Immunology meets neuroscience - opportunities for immune intervention in neurodegenerative diseases
(2011)Neuroinflammatory changes are characteristic of many, if not all, neurodegenerative diseases but the extent to which the immune system is involved in the pathogenesis of these diseases is unclear. The findings of several ... -
The kinematics of phonotactic steering in the cricket Gryllus bimaculatus
(2011)Female crickets, Gryllus bimaculatus, are attracted by the male calling song and approach singing males; a behaviour known as phonotaxis. Even tethered females walking on a trackball steer towards a computer-generated male ... -
A neural cell adhesion molecule-derived peptide, FGL, attenuates glial cell activation in the aged hippocampus
(Elsevier, 2011)Neuroglial activation is a typical hallmark of ageing within the hippocampus, and correlates with age-related cognitive deficits. We have used quantitative immunohistochemistry and morphometric analyses to investigate ... -
Androgen receptor signaling in prostate cancer development and progression
(Carcinogenesis Press, 2011)The androgen receptor (AR) signaling axis plays a critical role in the development, function and homeostasis of the prostate. The classical action of AR is to regulate gene transcriptional processes via AR nuclear ... -
Analysing the operative experience of basic surgical trainees in Ireland using a web-based logbook
(BioMed Central, 2011)Background: There is concern about the adequacy of operative exposure in surgical training programmes, in the context of changing work practices. We aimed to quantify the operative exposure of all trainees on the National ... -
Neuropathology in Mice Expressing Mouse Alpha-Synuclein
(PLoS, 2011)?-Synuclein (?SN) in human is tightly linked both neuropathologically and genetically to Parkinson's disease (PD) and related disorders. Disease-causing properties in vivo of the wildtype mouse ortholog (m?SN), which carries ... -
Long-term potentiation is impaired in CD200-deficient mice: a role for Toll-like receptor activation.
(2011)The membrane glycoprotein CD200 is expressed on several cell types including neurons whereas expression of its receptor, CD200R, is restricted principally to cells of the myeloid lineage, including microglia. The interaction ... -
Removal of Synaptic Ca2+-Permeable AMPA Receptors during Sleep.
(2011)here is accumulating evidence that sleep contributes to memory formation and learning, but the underlying cellular mechanisms are incompletely understood. To investigate the impact of sleep on excitatory synaptic transmission, ... -
Atorvastatin prevents age-related and amyloid-beta-induced microglial activation by blocking interferon-gamma release from natural killer cells in the brain
(2011)Abstract: Background: Microglial function is modulated by several factors reflecting the numerous receptors expressed on the cell surface, however endogenous factors which contribute to the age-related increase in microglial ... -
Neuroinflammatory changes increase the impact of stressors on neuronal function.
(2009)In the last few years, several research groups have reported that neuroinflammation is one feature common to several neurodegenerative diseases and that similar, although perhaps less profound, neuroinflammatory changes ... -
Effect of type 2 diabetes on the dynamic response characteristics of leg vascular conductance during exercise
(2011)In this study we tested the hypothesis that type 2 diabetes impairs the dynamic response of leg vascular conductance (LVC) during exercise. LVC (leg blood flow/mean arterial pressure) responses were studied during intermittent ...
