Psychiatry: Recent submissions
Now showing items 121-140 of 438
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Investigating the effects of schizophrenia genome-wide associated variants on white matter microstructure and brain morphology using diffusion tenson imaging and quantitative MRI
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2014)This thesis describes four studies that aim to to elucidate the effects of schizophrenia genome-wide associated variants on measures of white matter microstructure, cortical thickness, surface area and subcortical volume. ... -
Genetic correlation between amyotrophic lateral sclerosis and schizophrenia.
(2017)We have previously shown higher-than-expected rates of schizophrenia in relatives of patients with amyotrophic lateral sclerosis (ALS), suggesting an aetiological relationship between the diseases. Here, we investigate the ... -
Novel genetic loci associated with hippocampal volume
(2017)The hippocampal formation is a brain structure integrally involved in episodic memory, spatial navigation, cognition and stress responsiveness. Structural abnormalities in hippocampal volume and shape are found in several ... -
Moral cognition and homicide amongst forensic patients with schizophrenia and schizoaffective disorder: A cross-sectional cohort study
(2018)Abstract Forensic patients with schizophrenia who had carried out a homicide scored higher on a measure of moral cognition (MFQ-30) than other violent patients. Neurocognitive impairment was associated with homicide by ... -
Human subcortical brain asymmetries in 15,847 people worldwide reveal effects of age and sex
(2016)The two hemispheres of the human brain differ functionally and structurally. Despite over a century of research, the extent to which brain asymmetry is influenced by sex, handedness, age, and genetic factors is still ... -
No Reliable Association between Runs of Homozygosity and Schizophrenia in a Well-Powered Replication Study
(2016)It is well known that inbreeding increases the risk of recessive monogenic diseases, but it is less certain whether it contributes to the etiology of complex diseases such as schizophrenia. One way to estimate the effects ... -
The effects of depression and electroconvulsive therapy on retrospective memory and general cognition : a longitudinal study
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2012)The objectives of this work were to investigate the effects of depression on retrospective memory, in addition to attention, psychomotor and executive function, in depressed patients receiving pharmacotherapy treatment ... -
Enhancing studies of the connectome in autism using the autism brain imaging data exchange II
(2017)The second iteration of the Autism Brain Imaging Data Exchange (ABIDE II) aims to enhance the scope of brain connectomics research in Autism Spectrum Disorder (ASD). Consistent with the initial ABIDE effort (ABIDE I), that ... -
Neuropsychosocial predictors of outcomes in opioid dependent patients post-detoxification
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2015)The current treatment of choice for most opiate dependent persons is long term substitute prescribing. Detoxification is not an effective stand-alone treatment. Given the weak evidence base for detoxification coupled with ... -
Implications of cortical structure and connectivity in autism spectrum disorder
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2015)Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterised by early-onset deficits in social communication and interaction together with recurrent restricted repetitive behaviours (APA, 2013). Insights ... -
Genetic and molecular studies of rare variation in schizophrenia
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2014)Schizophrenia (SCZ) is a severe and debilitating disorder and it has a worldwide prevalence estimated at approximately 1%. The underlying pathogenesis of SCZ is poorly understood and there is a great need for diagnostic ... -
Decreased integrity of the fronto-temporal fibers of the left inferior occipito-frontal fasciculus associated with auditory verbal hallucinations in schizophrenia
(2016)Auditory verbal hallucinations (AVH: 'hearing voices') are found in both schizophrenia and post-traumatic stress disorder (PTSD). In this paper we first demonstrate that AVH in these two diagnoses share a qualitatively ... -
Methodological issues in event-related fMRI
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2005)Functional magnetic resonance imaging (fMRI) is a very powerful tool for localising psychological functions to specific brain areas. Recently, there has been a surge of interest in determining the functional differences ... -
The impact of schizophrenia genome wide association study genes on functional connectivity : a functional magnetic resonance imaging study
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2014)Genome-wide association studies (GWAS) have identified several genetic variants associated with increased schizophrenia risk. However, the specific mechanisms by which these variants increase risk are not fully understood. ... -
Functional investigation of neurodevelopmental effects of DISC1 and related psychosis risk genes
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2015)Schizophrenia (SCZ) is a severe neurodevelopmental disorder, which affects about 1% of the population worldwide, and whose symptoms start during early adulthood. SCZ is determined by the interaction of genetic and environmental ... -
Familiality of Co-existing ADHD and Tic Disorders: Evidence from a Large Sibling Study.
(2016)Background: The association of attention-deficit/hyperactivity disorder (ADHD) and tic disorder (TD) is frequent and clinically important. Very few and inconclusive attempts have been made to clarify if and how the combination ...
