Psychiatry: Recent submissions
Now showing items 141-160 of 438
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Phenotypic and molecular genetic analysis of autism
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2010)Autism is an early onset neurodevelopmental disorder affecting three core areas of behaviour - communication, social interaction and restricted repetitive behaviour. Although family and twin studies indicate a genetic ... -
Application of functional genomics to psychiatric disorders
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2012)Schizophrenia and bipolar disorder are common and severe psychiatric illnesses directly affecting approximately 1% of the population worldwide. Both have a devastating impact on the lives of those affected not to mention ... -
Frailty in an older population : the impact on community-dwelling elders, dementia patients and older caregivers
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2012)Frailty represents one of the greatest gerontological challenges faced by societies in coming years. Growing numbers of older citizens leads not only to increasing numbers of healthy elders, but also frail and disabled elders. -
Investigating risk factors and clinical correlates of copy number variants in Autism Spectrum Disorders and schizophrenia
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2013)Autism Spectrum Disorders (ASD) (OMIM 209850) and schizophrenia (OMIM 181510) are both complex neurodevelopmental disorders with extensive emotional and physical costs. Although there has been some progress in understanding ... -
Brain structure, function and connectivity in Autism Spectrum Disorders
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2012)In this study, two neuroimaging modalities were used to investigate neural connectivity in individuals with autism spectrum disorder; functional magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI). -
Electrophysiological event-related-potentials & their association with genome-wide-associated risk variants in schizophrenia
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2012)This thesis describes the use of electrophysiological event- related-potentials as a method for understanding, at the cortical level, the functional significance of putative schizophrenia susceptibility genes identified ... -
GWAS meta-analysis reveals novel loci and genetic correlates for general cognitive function: a report from the COGENT consortium
(2017)The complex nature of human cognition has resulted in cognitive genomics lagging behind many other fields in terms of gene discovery using genome-wide association study (GWAS) methods. In an attempt to overcome these ... -
Further evidence of alerted default network connectivity and association with theory of mind ability in schizophrenia
(2016)Background: Resting-state functional magnetic resonance imaging (rs-fMRI) has repeatedly shown evidence of altered functional connectivity of large-scale networks in schizophrenia. The relationship between these connectivity ... -
Functional neural differences in emotional regualtion between patients with MDD and healthy controls in the context of the vulnerability factors : family history of MDD, BDNF Val66Met polymorphism
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2012)Emotional regulation is a key mechanism which shows disturbances during major depressive disorder (MDD), and which may be modified by certain factors enhancing vulnerability to MDD. Two vulnerability factors were tested ... -
Characterisation of MACROD2, a putative autism susceptibility gene : translating Genome-Wide Analysis to causation
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2013)Genome Wide Association studies (GWAS) have been used to identify genetic markers which have strong statistical association with a disease. Establishing a functional consequence of association is required to determine a ... -
Fuctional and structural brain changes in ageing related to emotional processing
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2012)Of all mental abilities emotional processing is well-preserved in healthy ageing. In spite of this, the neural substrates of emotional processing in ageing are still not fully understood. In this project several experiments ... -
The impact of schizophrenia genome-wide association study genes on neurocognition and social cognition : a behavioural study
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2013)Genome wide association studies (GWAS) have established numerous previously unidentified variants associated with increased risk for schizophrenia (SZ). Exactly how most of these variants exert their influence remains ... -
Investigation of glutamatergic synapse genes in schizophrenia susceptibility : from linkage to genome-wide association studies
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2011)Schizophrenia is a common and severe mental illness which is highly heritable. Susceptibility to schizophrenia is likely to be caused by multiple genetic variants in combination with environmental risk factors. The ... -
Investigation of rare sequence variants in putative susceptibility genes for schizophrenia and autism spectrum disorders
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2013)Schizophrenia (SZ) and Autism Spectrum Disorders (ASD) are complex neuropsychiatric disorders that have a very large health, societal and economic burden in Ireland. They affect approximately 1% and 0.8% of the population ... -
Neurocognitive changes in associative- and working memory with aging
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2010)This thesis sought to determine the nature of associative- and working memory dechne during adulthood, and to try and elucidate some of the factors which contribute to this age- related mnemonic decline. In the first study ... -
The aging brain : an investigation into cognitive training and resting state networks in healthy older adults
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2013)Investigating the complexities surrounding the aging brain is of vital importance if we are to fully understand the mechanisms of aging. A greater understanding of aging may perhaps pave the way for new ideas and innovations ... -
Interferon-alpha-induced cognitive and affective impairments : contributions of prefrontal cortex and hippocampal formation
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2009)Interferon-alpha (IFN-a) is a potent antiviral agent useful in the treatment of many malignancies, but most widely used in the treatment of Hepatitis C. However, sinister adverse events appear as a consequence of ... -
Social cognition in borderline personality disorder : an MRI investigation
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2013)There is increasing evidence for subtle changes in brain morphology and function in patients with borderline personality disorder (BPD). The four study arms in this thesis seek to investigate the differences in personality, ... -
The neural basis of reward processing in Autism Spectrum Disorder : brain function, structure and connectivity
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2013)Autism spectrum disorder (ASD) is a pervasive developmental disorder defined by impairments in reciprocal social interaction and communication, as well as stereotyped behaviour and repetitive interests (Lord et al., 2011). ... -
Investigation of S100B gene as a risk factor for biopolar disorder and schizophrenia
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2012)Calcium-binding protein S100B has been implicated in the pathology of bipolar affective disorder (BPAD) and schizophrenia (SZP). S100B protein levels are elevated in serum of patients with both disorders compared to controls. ...
