Psychiatry: Recent submissions
Now showing items 341-360 of 438
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Predictability of oppositional defiant disorder and symptom dimensions in children and adolescents with ADHD combined type
(Cambridge University Press, 2010)Background Oppositional defiant disorder (ODD) is frequently co-occurring with attention deficit hyperactivity disorder (ADHD) in children and adolescents. Because ODD is a precursor of later conduct disorder (CD) and ... -
Two patients walk into a clinic...a genomics perspective on the future of schizophrenia.
(BioMed Central, 2011)Progress is being made in schizophrenia genomics, suggesting that this complex brain disorder involves rare, moderate to high-risk mutations and the cumulative impact of small genetic effects, coupled with environmental ... -
The Role of Variation at AßPP, PSEN1, PSEN2, and MAPT in Late Onset Alzheimer's Disease.
(2011)Rare mutations in A?PP, PSEN1, and PSEN2 cause uncommon early onset forms of Alzheimer's disease (AD), and common variants in MAPT are associated with risk of other neurodegenerative disorders. We sought to establish whether ... -
Exploration of empirical Bayes hierarchical modeling for the analysis of genome-wide association study data.
(2011)In the analysis of genome-wide association (GWA) data, the aim is to detect statistical associations between single nucleotide polymorphisms (SNPs) and the disease or trait of interest. These SNPs, or the particular regions ... -
DUNDRUM Restriction and Intrusion Liberty Ladders (DRILL)
(2011)This series of rating 'ladders' is intended to allow a quantitative and qualitative analysis of the use of restrictive and intrusive interventions as part of the therapeutic management of violence and aggression in psychiatric ... -
Neuronal cell adhesion genes: key players in risk for schizophrenia, bipolar disorder and other neurodevelopmental brain disorders?
(2010)The major mental disorders, schizophrenia and bipolar disorder are substantially heritable. Recent genomic studies have identified a small number of common and rare risk genes contributing to both disorders and support ... -
DUNDRUM-2: Prospective validation of a structured professional judgment instrument assessing priority for admission from the waiting list for a Forensic Mental Health Hospital
(2011)Background: The criteria for deciding who should be admitted first from a waiting list to a forensic secure hospital are not necessarily the same as for assessing need. Criteria were drafted qualitatively and tested in a ... -
The DUNDRUM Quartet: validation of structured professional judgement instruments DUNDRUM-3 assessment of programme completion and DUNDRUM-4 assessment of recovery in forensic mental health services
(2011)Background: Moving a forensic mental health patient from one level of therapeutic security to a lower level or to the community is influenced by more than risk assessment and risk management. We set out to construct and ... -
Multiple Indices of Diffusion Identifies White Matter Damage in Mild Cognitive Impairment and Alzheimer s Disease
(PLoS, 2011)The study of multiple indices of diffusion, including axial (DA), radial (DR) and mean diffusion (MD), as well as fractional anisotropy (FA), enables WM damage in Alzheimer's disease (AD) to be assessed in detail. Here, ... -
Residential mobility among patients admitted to acute psychiatric wards
(Elsevier, 2011)Residential mobility among those with mental disorders is consistently associated with hospital admission. We studied 4485 psychiatric admissions in South London, aiming to describe the prevalence, timing and associations ... -
Accurately assessing the risk of schizophrenia conferred by rare copy-number variation affecting genes with brain function.
(2010)Investigators have linked rare copy number variation (CNVs) to neuropsychiatric diseases, such as schizophrenia. One hypothesis is that CNV events cause disease by affecting genes with specific brain functions. Under these ... -
Genome-wide association studies: a primer.
(Cambridge University Press, 2010)There have been nearly 400 genome-wide association studies (GWAS) published since 2005. The GWAS approach has been exceptionally successful in identifying common genetic variants that predispose to a variety of complex ... -
Experience-dependent plasticity in visual cortex: Dendritic spines and visual responsiveness.
(2011)To determine the relationship between synaptic structural changes and cortical function, we recently published a study where we imaged dendritic spines using two-photon in vivo microscopy while monitoring network activity ... -
Is "clinical" insight the same as "cognitive" insight in schizophrenia?
(2009)Poor insight is associated with impaired cognitive function in psychosis. Whether poor clinical insight overlaps with other aspects of self-awareness in schizophrenia, such as cognitive self-awareness, is unclear. We ... -
The relationship between ADHD and key cognitive phenotypes is not mediated by shared familial effects with IQ
(2011)Background. Twin and sibling studies have identified specific cognitive phenotypes that may mediate the association between genes and the clinical symptoms of attention deficit hyperactivity disorder (ADHD). ADHD is also ... -
Genetic Classification of Populations using Supervised Learning.
(2011)There are many instances in genetics in which we wish to determine whether two candidate populations are distinguishable on the basis of their genetic structure. Examples include populations which are geographically ... -
Functionality of promoter microsatellites of arginine vasopressin receptor 1A (AVPR1A): implications for Autism.
(BIOMED CENTRAL, 2011)Background: Arginine vasopressin (AVP) has been hypothesized to play a role in aetiology of autism based on a demonstrated involvement in the regulation of social behaviours. The arginine vasopressin receptor 1A gene (AVPR1A) ... -
The DUNDRUM-1 structured professional judgment for triage to appropriate levels of therapeutic security: retrospective-cohort validation study.
(2011)BACKGROUND: The assessment of those presenting to prison in-reach and court diversion services and those referred for admission to mental health services is a triage decision, allocating the patient to the appropriate ... -
Predictability and construct validity of oppositional defiant disorder in children and adolescents with ADHD combined type.
(Cambridge University Press, 2010)Background. Oppositional defiant disorder (ODD) is frequently co-occurring with attention deficit hyperactivity disorder (ADHD) in children and adolescents. Because ODD is a precursor of later conduct disorder (CD) ... -
Regional Variation in Electroconvulsive Therapy Use
(2011)Although electroconvulsive therapy (ECT) is the most powerful treatment for depression, substantial variability in use has been described in Ireland. The Mental Health Commission collects usage data from approved centres ...
