Psychiatry: Recent submissions
Now showing items 361-380 of 438
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A Multiple Indicators Multiple Causes (MIMIC) model of Behavioural and Psychological Symptoms in Dementia (BPSD).
(2011)Introduction Although there is evidence for distinct behavioural sub-phenotypes in Alzheimer's disease (AD), their inter-relationships and the effect of clinical variables on their expression have been little ... -
Association of serotonin and dopamine gene pathways with behavioural subphenotypes in dementia.
(2012)Genetic association studies investigating the association between genes of serotonergic and dopaminergic systems and behavioral and psychological symptoms in dementia (BPSD) are contradictory. We have utilized 1008 probable ... -
A genomewide scan for common alleles affecting risk for autism.
(2010)Although autism spectrum disorders (ASDs) have a substantial genetic basis, most of the known genetic risk has been traced to rare variants, principally copy number variants (CNVs). To identify common risk variation, the ... -
ZNF804A risk allele is associated with relatively intact gray matter volume in patients with schizophrenia
(Elsevier, 2010)ZNF804A rs1344706 is the first genetic risk variant to achieve genome wide significance for psychosis. Following earlier evidence that patients carrying the ZNF804A risk allele had relatively spared memory function compared ... -
Multiplex Target Enrichment Using DNA Indexing for Ultra-High Throughput SNP Detection.
(2011)Screening large numbers of target regions in multiple DNA samples for sequence variation is an important application of next-generation sequencing but an efficient method to enrich the samples in parallel has yet to be ... -
A genome-wide linkage and association scan reveals novel loci for autism.
(Nature, 2009)Although autism is a highly heritable neurodevelopmental disorder, attempts to identify specific susceptibility genes have thus far met with limited success 1. Genome-wide association studies (GWAS) using half a million ... -
Microduplications of 16p11.2 are associated with schizophrenia
(Nature, 2009)Recurrent microdeletions and microduplications of a 600-kb genomic region of chromosome 16p11.2 have been implicated in childhood-onset developmental disorders. We report the association of 16p11.2 microduplications with ... -
Identifying relationships among genomic disease regions: predicting genes at pathogenic SNP associations and rare deletions.
(2009)Translating a set of disease regions into insight about pathogenic mechanisms requires not only the ability to identify the key disease genes within them, but also the biological relationships among those key genes. Here ... -
A genomewide scan for common alleles affecting risk for autism.
(Oxford University Press, 2010)Although autism spectrum disorders (ASDs) have a substantial genetic basis, most of the known genetic risk has been traced to rare variants, principally copy number variants (CNVs). To identify common risk variation, the ... -
What have the genomics ever done for the psychoses?
(2010)Background: Despite the substantial heritability of the psychoses and their genuine public health burden, the applicability of the genomic approach in psychiatry has been strongly questioned or prematurely dismissed.Method ... -
A frailty instrument for primary care: findings from the Survey of Health, Ageing and Retirement in Europe (SHARE).
(2010)Background: A frailty paradigm would be useful in primary care to identify older people at risk, but appropriate metrics at that level are lacking. We created and validated a simple instrument for frailty screening in ... -
Genes predict village of origin in rural Europe.
(2010)The genetic structure of human populations is important in population genetics, forensics and medicine. Using genome-wide scans and individuals with all four grandparents born in the same settlement, we here demonstrate ... -
The Psychosis Susceptibility gene ZNF804A: associations, functions and phenotypes
(2010)As the first gene to have achieved genome-wide significance for psychosis, ZNF804A has predictably been a subject of intense research activity. We review the evidence to date for the association between schizophrenia and ... -
Psychosis Susceptibility Gene ZNF804A and Cognitive Performance in Schizophrenia
(2010)Background: The Zinc Finger Protein 804A gene (ZNF804A) has been implicated in schizophrenia (SZ) susceptibility by several genome-wide association studies (GWAS). ZNF804A is brain-expressed, but of unknown function. ... -
Ethnic minority populations and child psychiatry services: An Irish study
(Elsevier, 2010)Background Ethnically, Ireland has diversified greatly over the last twelve years changing from a country of emigration to one of immigration. Blanchardstown, a western suburb of Dublin, is one of the most ethnically ... -
Electroconvulsive therapy, capacity and the law in Ireland.
(Irish Institute of Psychological Medicine, 2009)The Mental Health Act (MHA) 2001 has major implications for treating patients with electroconvulsive therapy (ECT), especially as those referred for treatment are among the most severely ill and often lose capacity. Under ... -
Early Visual Processing Deficits in Dysbindin-Associated Schizophrenia
(2008)Background: Variation at the dysbindin gene (DTNBP1) has been associated with increased risk for schizophrenia in numerous independent samples and recently with deficits in general and domain-specific cognitive processing. ... -
Microstructural Correlates of Resilience against Major Depressive Disorder: Epigenetic Mechanisms?
(2010)Mental disorders are a major cause of long-term disability and are a direct cause of mortality, with approximately 800.000 individuals dying from suicide every year worldwide ? a high proportion of them related to major ... -
Molecular pathways involved in neuronal cell adhesion and membrane scaffolding contribute to schizophrenia and bipolar disorder susceptibility.
(2011)Susceptibility to schizophrenia and bipolar disorder may involve a substantial, shared contribution from thousands of common genetic variants each of small effect. Identifying if risk variants map to specific molecular ... -
The neuronal adaptor protein X11alpha interacts with the copper chaperone for SOD1 and regulates SOD1 activity.
(2001)The neuronal adaptor protein X11a participates in the formation of multiprotein complexes and intracellular trafficking. It contains a series of discrete protein-protein interaction domains including two contiguous ...
