Psychiatry: Recent submissions
Now showing items 41-60 of 438
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Structural Changes of Brain Areas Involved in Emotion and Memory Processing across Lifespan
(Trinity College Dublin. School of Medicine. Discipline of Psychiatry, 2020)People are defined by their genes, familiar background and personal experiences, that can have either a negative or positive impact. Altogether, this represents and shapes their decisions, behaviours and relationships with ... -
Exploring the molecular mechanisms of Rett syndrome
(Trinity College Dublin. School of Medicine. Discipline of Psychiatry, 2020)Rett Syndrome (RTT) is a severe neurological disorder that onsets between 6 to 18 months of age, after a period of apparently normal development. RTT affects approximately 1 in every 10000 to 15000 live births and is ... -
Molecular pathways of depression and antidepressant therapies for treatment resistant depression
(Trinity College Dublin. School of Medicine. Discipline of Psychiatry, 2020)According to the World Health Organisation, depression is the most common psychiatric disorder. Despite this, the pathophysiology of depression is unclear. Electroconvulsive therapy (ECT) is the most acutely effective ... -
Attention Deficit Hyperactivity Disorder (ADHD) and 5-HT2C receptor: A slight increase in the transmission of Cys23 to ADHD cases
(1999)Recent evidence suggests that interaction with and balancebetween serotonergicand dopaminergic neurotransmissionis important in the mediation of hyperactive behaviour.Animal model studies have ®rmly implicated the genes ... -
Executive Function in Routine Childhood ADHD Assessment
(2010)Aims: To determine the metacognitive deficits and behavioural and emotional regulation deficits among a group of children undergoing treatment for ADHD and to compare these with the hyperactivity/inattentive and behavioural ... -
Developmental comorbidity assessment in childhood ADHD
(2003)Introduction: Childhood ADHD typically presents with comorbidites. Assessment tools for developmental screening vary greatly in length and complexitity, and parental preference has an impact on the usefulness of clinical ... -
In God we trust? Organised religion and personal beliefs as resources and coping strategies, and their implications for health in parents with a child on the autistic spectrum
(1999)This paper is part of a larger study looking at the impact on 60 families of having a child with autistic spectrum disorder. Here the roles played by organised reliagion and personal belief and their relationship with ... -
Screening for autistic spectrum disorder at the 18-month developmental assessment: a population-based study
(2007)The objectives of this study were to assess the feasibility of administering the CHecklist for Autism in Toddlers (CHAT) at the 18-month developmental check, estimate the prevalence of screening positive for autism at the ... -
Autistic Tendencies: The Consequences for Our Culture
(2006)Professor Michael Fitzgeraldtalks withJoe Griffinabout the powerful impact, both positive and negative, of autistic thinking in diverse walks of life. -
Assessing the effects of coenzyme QIO in schizophrenia & schizoaffective disorder: a randomised, placebo controlled trial
(Trinity College Dublin. School of Medicine. Discipline of Psychiatry, 2020)Background: Schizophrenia is a complex, heterogeneous, neurodevelopmental disorder. Cognitive impairments and negative symptoms such as avolition and asociality are prevalent in the majority of patients with a diagnosis ... -
The importance of cognitive deficits for forensic mental health patients with schizophrenia or schizoaffective disorder
(Trinity College Dublin. School of Medicine. Discipline of Psychiatry, 2020)Forensic Mental Health Services (FMHS) provide care and treatment to a minority of people with mental illness like schizophrenia or schizoaffective disorder, who come into contact with law enforcement agencies (Kennedy et ... -
Investigation of α-tubulins as translational biomarkers of major depressive disorder: indications for disease severity and treatment efficacy
(Trinity College Dublin. School of Medicine. Discipline of Psychiatry, 2020)Introduction: Major Depressive Disorder is a significant cause of disability worldwide. In a 2017 report, the World Health Organisation estimated that 320 million people suffered from depression globally. Although several ... -
The SNP ratio test: pathway analysis of genome-wide association datasets
(2009)Summary: We present a tool that assesses the enrichment of significant associations from genome-wide association studies (GWAS) in a pathway context. The SNP ratio test (SRT) compares the proportion of significant to ... -
Mental state decoding versus mental state reasoning as a mediator between cognitive and social function in psychosis
(2008)Theory of mind deficits in schizophrenia have been parsed into mental state reasoning and mental state decoding components. We report that mental state decoding as measured by the `Eyes task? better predicted social ... -
Classical Human Leukocyte Antigen Alleles and C4 Haplotypes Are Not Significantly Associated With Depression
(2020)BACKGROUND: The prevalence of depression is higher in individuals with autoimmune diseases, but the mechanisms underlying the observed comorbidities are unknown. Shared genetic etiology is a plausible explanation for ... -
Epigenome-wide meta-analysis of blood DNA methylation and its association with subcortical volumes: findings from the ENIGMA Epigenetics Working Group
(2019)DNA methylation, which is modulated by both genetic factors and environmental exposures, may offer a unique opportunity to discover novel biomarkers of disease-related brain phenotypes, even when measured in other tissues ... -
No relationship between fornix and cingulum degradation and within-network decreases in functional connectivity in prodromal Alzheimer???s disease
(2019)Introduction: The earliest changes in the brain due to Alzheimer’s disease are associated with the neural networks related to memory function. We investigated changes in functional and structural connectivity among ... -
Differential default mode network trajectories in asymptomatic individuals at risk for Alzheimer's disease
(2019)Introduction: The longitudinal trajectories of functional brain dynamics and the impact of genetic risk factors in individuals at risk for Alzheimer's disease are poorly understood. Methods: In a large-scale monocentric ...
