Psychiatry: Recent submissions
Now showing items 61-80 of 438
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Brain Aβ load association and sexual dimorphism of plasma BACE1 concentrations in cognitively normal individuals at risk for AD
(2019)Introduction: Successful development of effective β-site amyloid precursor protein cleaving enzyme 1 (BACE1)–targeted therapies for early stages of Alzheimer's disease requires biomarker-guided intervention strategies ... -
Genomic Dissection of Bipolar Disorder and Schizophrenia, Including 28 Subphenotypes
(2018)Schizophrenia and bipolar disorder are two distinct diagnoses that share symptomology. Understanding the genetic factors contributing to the shared and disorder-specific symptoms will be crucial for improving diagnosis and ... -
Epigenetic variance in dopamine D2 receptor: a marker of IQ malleability?
(2018)Genetic and environmental factors both contribute to cognitive test performance. A substantial increase in average intelligence test results in the second half of the previous century within one generation is unlikely to ... -
Grey Matter Volume Differences Associated with Extremely Low Levels of Cannabis Use in Adolescence.
(2019)Rates of cannabis use among adolescents are high, and are increasing concurrent with changes in the legal status of marijuana and societal attitudes regarding its use. Recreational cannabis use is understudied, especially ... -
Basal forebrain volume, but not hippocampal volume, is a predictor of global cognitive decline in patients with alzheimer's disease treated with cholinesterase inhibitors
(2018)Background: Predicting the progression of cognitive decline in Alzheimer's disease (AD) is important for treatment selection and patient counseling. Structural MRI markers such as hippocampus or basal forebrain volumes ... -
Genetic risk for schizophrenia and autism, social impairment and developmental pathways to psychosis
(2018)While psychotic experiences (PEs) are assumed to represent psychosis liability, general population studies have not been able to establish significant associations between polygenic risk scores (PRS) and PEs. Previous work ... -
Inferring the model and onset of natural selection under varying population size from the site frequency spectrum and haplotype structure
(2019)A fundamental question about adaptation in a population is the time of onset of the selective pressure acting on beneficial alleles. Inferring this time, in turn, depends on the selection model. We develop a framework of ... -
Comment on "Nuclear genomic sequences reveal that polar bears are an old and distinct bear lineage".
(2013)Based on nuclear and mitochondrial DNA, Hailer et al. (Reports, 20 April 2012, p. 344) suggested early divergence of polar bears from a common ancestor with brown bears and subsequent introgression. Our population genetic ... -
Family-based association and molecular genetic analysis of genes implicated in the aetiology of autism
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2009)Autism is an early onset neurodevelopmental disorder affecting three core areas of behaviour - communication, social behaviour and restricted/repetitive behaviour. Although family and twin studies indicate a genetic ... -
Multimodal Approach to Endophenotype Discovery in Disorders with Genetic Liability
(Trinity College Dublin. School of Medicine. Discipline of Psychiatry, 2019)Neurodevelopmental and Neurodegenerative disorders constitute a huge weight on society in terms of human suffering and economic cost. In recent years an increasing amount of emphasis has been placed on investigating the ... -
A NOS1 variant implicated in cognitive performance influences evoked neural responses during a hight density EEG study of early visual perception.
(Wiley Open Access, 2012)Background: The nitric oxide synthasase‐1 gene (NOS1) has been implicated in mental disorders including schizophrenia and variation in cognition. The NOS1 variant rs6490121 identified in a genome wide association study of ... -
Convergent functional genomics of schizophrenia: from comprehensive understanding to genetic risk prediction
(2012)We have used a translational convergent functional genomics (CFG) approach to identify and prioritize genes involved in schizophrenia, by gene-level integration of genome-wide association study data with other genetic and ... -
A randomized controlled trial of cognitive remediation for a national cohort of forensic patients with schizophrenia or schizoaffective disorder
(2019)Background: Evidence is accumulating that Cognitive Remediation Training (CRT) is effective for ameliorating cognitive deficits experienced by patients with schizophrenia and accompanying functional impairment. There has ... -
Prospective observational cohort study of 'treatment as usual' over four years for patients with schizophrenia in a national forensic hospital.
(2018)Background: We evaluated change in response to multi-modal psychosocial ‘treatment as usual’ programs offered within a forensic hospital. Methods: Sixty nine patients with a diagnosis of schizophrenia or schizoaffective ... -
Cortical Brain Abnormalities in 4474 Individuals With Schizophrenia and 5098 Control Subjects via the Enhancing Neuro Imaging Genetics Through Meta Analysis (ENIGMA) Consortium
(2018)Background: The profile of cortical neuroanatomical abnormalities in schizophrenia is not fully understood, despite hundreds of published structural brain imaging studies. This study presents the first meta-analysis of ... -
Cross-ancestry genome-wide association analysis of corneal thickness strengthens link between complex and Mendelian eye diseases
(2018)Central corneal thickness (CCT) is a highly heritable trait associated with complex eye diseases such as keratoconus and glaucoma. We perform a genome-wide association meta-analysis of CCT and identify 19 novel regions. ... -
Estimation of Genetic Correlation via Linkage Disequilibrium Score Regression and Genomic Restricted Maximum Likelihood
(Elsevier (Cell Press), 2018)Genetic correlation is a key population parameter that describes the shared genetic architecture of complex traits and diseases. It can be estimated by current state-of-art methods, i.e., linkage disequilibrium score ... -
Dissection of the genetics of Parkinson's disease identifies an additional association 5′ of SNCA and multiple associated haplotypes at 17q21
(Oxford University Press, 2010)We performed a genome-wide association study (GWAS) in 1705 Parkinson's disease (PD) UK patients and 5175 UK controls, the largest sample size so far for a PD GWAS. Replication was attempted in an additional cohort of 1039 ... -
Cortical patterning of abnormal morphometric similarity in psychosis is associated with brain expression of schizophrenia-related genes
(2019)Despite significant research, the biological mechanisms underlying schizophrenia are still unclear. We shed light on structural brain differences in psychosis using an approach called morphometric similarity mapping, which ... -
He said, she said: Autism spectrum diagnosis and gender differentially affect relationships between executive functions and social communication
(2019)Autism spectrum disorder is characterized by difficulties with social communication, with a preponderance in males. Evidence supports a relationship between metacognitive executive functions (e.g. planning, ...
