Psychiatry: Recent submissions
Now showing items 421-438 of 438
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A Randomized, Controlled Trial With 6-Month Follow-Up of Repetitive Transcranial Magnetic Stimulation and Electroconvulsive Therapy for Severe Depression
(American Psychiatric Association, 2007)OBJECTIVE: Repetitive transcranial magnetic stimulation (rTMS) has been reported to be as effective as electroconvulsive therapy (ECT) for major depression. The authors conducted a multicenter randomized, controlled trial ... -
Euthanasia, assisted suicide and psychiatry: a Pandora's box
(2002)Euthanasia has been defined as `the bringing about of a gentle and easy death for someone suffering from an incurable and painful disease or in an irreversible coma? (Pearsall & Trumble, 1996). It accounts for nearly 2% ... -
Familial amyotrophic lateral sclerosis-linked SOD1 mutants perturb fast axonal transport to reduce axonal mitochondria content.
(Oxford University Press, 2007)Amyotrophic lateral sclerosis (ALS) is a late-onset neurological disorder characterized by death of motoneurons. Mutations in Cu/Zn superoxide dismutase-1 (SOD1) cause familial ALS but the mechanisms whereby they induce ... -
The c-Abl tyrosine kinase phosphorylates the Fe65 adaptor protein to stimulate Fe65/amyloid precursor protein nuclear signaling.
(American Society for Biochemistry and Molecular Biology, 2004)The amyloid precursor protein (APP) is proteolytically processed to release a C-terminal domain that signals to the nucleus to regulate transcription of responsive genes. The APP C terminus binds to a number of phosphotyrosine ... -
ALS2/Alsin regulates Rac-PAK signaling and neurite outgrowth.
(American Society for Biochemistry and Molecular Biology, 2005)Rac and its downstream effectors p21-activated kinase (PAK) family kinases regulate actin dynamics within growth cones to control neurite outgrowth during development. The activity of Rac is stimulated by guanine ... -
Amyloid ? peptides in plasma in early diagnosis of Alzheimer's disease: A multicenter study with multiplexing
(Elsevier, 2009)We measured concentrations of A? peptides 1?42 and 1?40, and their ratio in plasma of patients carefully categorized clinically and neurochemically as having AD or other dementias with a newly commercially available ... -
Age-related networks of regional covariance in MRI gray matter: Reproducible multivariate patterns in healthy aging
(Elsevier, 2009)Healthy aging is associated with brain volume reductions that involve the frontal cortex, but also affect other brain regions. We sought to identify an age-related network pattern of MRI gray matter using a multivariate ... -
White matter microstructure underlying default mode network connectivity in the human brain
(2010)Resting state functional magnetic resonance imaging (fMRI) reveals a distinct network of correlated brain function representing a default mode state of the human brain. The underlying structural basis of this functional ... -
Total and phosphorylated Tau protein as biological markers of Alzheimer's disease
(Elsevier, 2009)Advances in our understanding of tau-mediated neurodegeneration in Alzheimer?s disease (AD) are moving this disease pathway to center stage for the development of biomarkers and disease modifying drug discovery efforts. ... -
X11beta rescues memory and long-term potentiation deficits in Alzheimer's disease APPswe Tg2576 mice.
(2009)Increased production and deposition of amyloid ?-protein (A?) are believed to be key pathogenic events in Alzheimer?s disease. As such, routes for lowering cerebral A? levels represent potential therapeutic targets for ... -
Genetic mouse models of Alzheimer's disease.
(Freund and Pettman, 2005)In the current minireview, we focus on genetic mouse models of Alzheimer's disease (AD). Because various excellent, up-to-date reviews, special issues, and reliable websites are already dedicated to the genetics of Alzheimer's ... -
Replication of an Association of a Promoter Polymorphism of the Dopamine Transporter Gene and Attention Deficit Hyperactivity Disorder
(Elsevier, 2009)Genetic associations for Attention Deficit Hyperactivity Disorder (ADHD), a common highly heritable childhood behavioural disorder, require replication in order to establish whether they are true positive findings. The ... -
Assessing neuronal networks: Understanding Alzheimer's disease
(2009)Findings derived from neuroimaging of the structural and functional organization of the human brain have led to the widely supported hypothesis that neuronal networks of temporally coordinated brain activity across different ... -
Application of simulated annealing to the biclustering of gene expression data
(2006)In a gene expression data matrix, a bicluster is a submatrix of genes and conditions that exhibits a high correlation of expression activity across both rows and columns. The problem of locating the most significant ... -
Imaging the genetics of executive function.
(Elsevier, 2008)Recent advances in neuroimaging technologies have allowed ever more detailed studies of the human brain. The combination of neuroimaging techniques with genetics may provide a more sensitive measure of the influence of ...
