Psychiatry: Recent submissions
Now showing items 401-420 of 438
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The Depression Network (DeNT) Study: Methodology and Sociodemographic characteristics of the first 470 affected sibling pairs from a large multi-site linkage genetics study
(BMC, 2004)Background: The Depression Network Study (DeNt) is a multicentre study designed to identify genes and/or loci linked to and/or associated with susceptibility to unipolar depression in Caucasian families. This study ... -
Is 'Clinical' insight the same as 'Cognitive' insight in schizophrenia?
(Cambridge University Press, 2009)Poor insight is associated with impaired cognitive function in psychosis. Whether poor clinical insight overlaps with other aspects of self-awareness in schizophrenia, such as cognitive self-awareness, is unclear. We ... -
Whole genome linkage scan of recurrent depressive disorder from the depression network study
(Oxford University Press, 2005)Genome-wide linkage analysis was carried out in a sample of 497 sib pairs concordant for recurrent major depressive disorder (MDD). There was suggestive evidence for linkage on chromosome 1p36 where the LOD score for ... -
Automated detection of brain atrophy patterns based on MRI for the prediction of Alzheimer's disease
(2010)Subjects with mild cognitive impairment (MCI) have an increased risk to develop Alzheimer?s disease (AD). Voxel-based MRI studies have demonstrated that widely distributed cortical and subcortical brain areas show atrophic ... -
Association between dopamine transporter (DAT1)genotype, left sided inattention, and an enhanced response to methylphenidate in attention deficit hyperactivity disorder
(2005)A polymorphism of the dopamine transporter gene (DAT1, 10-repeat) is associated with attention-deficit hyperactivity disorder (ADHD) and has been linked to an enhanced response to methylphenidate (MPH). One aspect of the ... -
Combined Analysis from Eleven Linkage Studies of Bipolar Disorder Provides Strong Evidence of Susceptibility Loci on Chromosomes 6q and 8q
(Elsevier, 2005)Several independent studies and meta-analyses aimed at identifying genomic regions linked to bipolar disorder (BP) have failed to find clear and consistent evidence of linkage regions. Our hypothesis is that combining the ... -
Confirmation of association between autism and the mitochondrial aspartate/glutamate carrier SLC25A12 gene on chromosome 2q31
(American Psychiatric Association, 2005)OBJECTIVE: Autism is a neurodevelopmental disorder with childhood onset and a known major genetic component. A recent study identified a highly significant association between autism and a two-single-nucleotide-polymorphism ... -
Preferential Transmission of Paternal Alleles at Risk Genes in Attention Deficit/Hyperactivity Disorder
(2005)Family, twin, and adoption studies have demonstrated a significant genetic contribution to the etiology of attention-deficit/hyperactivity disorder (ADHD). Pharmacological, neuroimaging, and animal-model findings suggest ... -
Spatial attentional bias as a marker of genetic risk, symptom severity and stimulant response in ADHD.
(2007)Attention-deficit hyperactivity disorder (ADHD) is a heritable childhood onset disorder that is marked by variability at multiple levels including clinical presentation, cognitive profile, and response to stimulant ... -
Gene-environment interplay in attention-deficit hyperactivity disorder and the importance of a develomental perspective
(The Royal College of Psychiatrists, 2007)Attention-deficit hyperactivity disorder (ADHD) varies in its clinical presentation and course. Susceptibility gene variants for ADHD and associated antisocial behaviour are being identified with emerging evidence of ... -
Dissociation in performance of children with ADHD and high-functioning autism on a task of sustained attention.
(Elsevier, 2007)Attention deficit hyperactivity disorder (ADHD) and autism are two neurodevelopmental disorders associated with prominent executive dysfunction, which may be underpinned by disruption within fronto-striatal and fronto-parietal ... -
Recurrent Rearrangements of Chromosome 1q21.1 and Variable Pediatric Phenotypes
(Massachusetts Medical Society, 2008)Background Duplications and deletions in the human genome can cause disease or predispose persons to disease. Advances in technologies to detect these changes allow for the routine identification of submicroscopic imbalances ... -
Psychiatric Genetics in the post genome age
(The Royal College of Psychiatrists, 2003)Less than 50 years after publication of the structure of DNA, we possess a working draft of the human genome and expect a completed draft listing all genes and their location by 2003 (International Human Genome Sequencing ... -
Bipolar affective puerperal psychosis- genome-wide significant evidence for linkage to chromosome 16.
(American Psychiatric Publishing, 2007)OBJECTIVE: Vulnerability to the triggering of bipolar episodes by childbirth aggregates in families and may define a genetically relevant subtype of bipolar disorder. The authors conducted a search by systematic whole ... -
Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder.
(Nature Publishing Group, 2008)To identify susceptibility loci for bipolar disorder, we tested 1.8 million variants in 4,387 cases and 6,209 controls and identified a region of strong association (rs10994336, P = 9.1 10-9) in ANK3 (ankyrin G). We also ... -
Mental state decoding v. mental state reasoning as a mediator between cognitive and social function in psychosis
(The Royal College of Psychiatrists, 2008)Theory of mind deficits in schizophrenia have been parsed into mental state reasoning and mental state decoding components. We report that mental state decoding as measured by the `Eyes task? better predicted social function ... -
An assessment of the Irish population for large-scale genetic mapping studies involving epilepsy and other complex diseases
(Nature Publishing Group, 2008)The recent completion of the International HapMap Project has rapidly advanced our understanding of linkage disequilibrium (LD) in the human genome. Today, tagging SNPs (tSNPs) can be quickly and easily selected and ... -
Identification of a novel, membrane-associated neuronal kinase, cyclin-dependent kinase 5/p35-regulated kinase.
(The Society for Neuroscience, 2003)Here we characterize a novel neuronal kinase, cyclin-dependent kinase 5 (cdk5)/p35-regulated kinase (cprk). Cprk is a member of a previously undescribed family of kinases that are predicted to contain two N-terminal ... -
Electroconvulsive therapy - state of the art
(The Royal College of Physicians, 2003)Although electroconvulsive therapy (ECT) has been available for more than 60 years it is still the most acutely effective antidepressant treatment available (McCall, 2001). However, despite substantial advances in safety ...
