School of Medicine: Recent submissions
Now showing items 181-200 of 3444
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Early life adversity and age acceleration at mid-life and older ages indexed using the next-generation GrimAge and Pace of Aging epigenetic clocks.
(2021)Objective: This retrospective cross-sectional study was designed to explore whether the experience of childhood adversity was associated with epigenetic age acceleration in mid-life and older ages using the next ... -
GrimAge outperforms other epigenetic clocks in the prediction of age-related clinical phenotypes and all-cause mortality.
(2021)The aging process is characterized by the presence of high interindividual variation between individuals of the same chronical age prompting a search for biomarkers that capture this heterogeneity. Epigenetic clocks measure ... -
Epigenetic clocks and allostatic load reveal potential sex-specific drivers of biological ageing
(2019)Allostatic load (AL) and epigenetic clocks both attempt to characterize the accelerated aging of biological systems, but at present it is unclear whether these measures are complementary or distinct. This study examines ... -
Speed of Heart Rate Recovery in Response to Orthostatic Challenge: A Strong Risk Marker of Mortality.
(2016)Rationale: Speed of heart rate recovery (HRR) may serve as an important biomarker of aging and mortality. Objective: To examine whether the speed of HRR after an orthostatic maneuver (ie, active stand from supine position) ... -
Cerebral haemodynamics in older adults: Multi-modal studies utilizing near infrared spectroscopy and non-invasive continuous blood pressure monitoring in a large longitudinal cohort
(Trinity College Dublin. School of Medicine. Discipline of Medical Gerontology, School of Medicine, Trinity College Dublin, 2025)Sufficient cerebral blood flow (CBF) is critical for brain health and normal cognitive function, and cerebral hypoperfusion is implicated as a pathway to cognitive decline, as well as other adverse outcomes such as falls, ... -
An Exploration of Cellular Signatures of Ageing, and the Effects of Age-Related Dysregulated Myeloid Circadian Rhythm in Retinal Disease.
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2025)Age-related macular degeneration (AMD) is the most common cause of vision loss and blindness in the elderly population across the developed world. This disease is characterised by a gradual degeneration and death of ... -
Validation of the 8-item Centre for Epidemiological Studies Depression Scale in a cohort of community-dwelling older people: data from The Irish Longitudinal Study on Ageing (TILDA)
(2018)Background The aim of this study was to validate the 8-item Centre for Epidemiological Studies Depression Scale (CES- D-8) against the 20-item version (CES-D-20) in a large sample of community-dwelling older people. Methods ... -
Depressive symptoms among older adults pre- and post- COVID-19 pandemic
(2021)Objectives: It is a concern that public health measures to prevent older people contracting COVID-19 could lead to a rise in mental health problems such as depression. The aim of this study therefore is to examine trends ... -
Vitamin D Deficiency Is Associated With an Increased Likelihood of Incident Depression in Community-Dwelling Older Adults.
(2019)Objective: To examine the prospective relationship between vitamin D status and incident depression in a large cohort of nondepressed community-dwelling older people. Design: Longitudinal study examining the relationship ... -
The `Wish to Die' in later life: prevalence, longitudinal course and mortality. Data from TILDA
(2021)Background: ‘Wish to Die’ (WTD) involves thoughts of or wishes for one’s own death or that one would be better off dead. Objective: To examine the prevalence, longitudinal course and mortality-risk of WTD in community-dwelling ... -
What Is the Relationship Between Orthostatic Blood Pressure and Spatiotemporal Gait in Later Life?
(Wiley, 2020)BACKGROUND/OBJECTIVES: Little work to date has examined the relationship between gait performance and blood pressure (BP) recovery after standing in later life. The aim of this study is to clarify the association of ... -
Do Differences in Spatiotemporal Gait Parameters Predict the Risk of Developing Depression in Later Life?
(2019)BACKGROUND/OBJECTIVES: There is growing interest in the association between gait disturbance and depression in later life. The aim of this study is to clarify the longitudinal relationship between specific gait parameters ... -
Slower speed of blood pressure recovery after standing is associated with accelerated brain aging: Evidence from The Irish Longitudinal Study on Ageing (TILDA)
(2024)Background: Impaired recovery of blood pressure (BP) in response to standing up is a prevalent condition in older individuals. We evaluated the relationship between the early recovery of hemodynamic responses to standing and ... -
What is the Longitudinal Relationship between Gait Abnormalities and Depression in a Cohort of Community-Dwelling Older People? Data From the Irish Longitudinal Study on Ageing (TILDA)
(2018)Objective: Does baseline gait disturbance predict incident depression in a cohort of community-dwelling older people? Methods: This is a longitudinal study, embedded within the Irish Longitudinal Study on Ageing (TILDA), ... -
The association between frontal lobe perfusion and depressive symptoms in later life
(2019)Background: Deficits in frontal lobe perfusion have been demonstrated in late- life depression; however, studies to date have generally involved small numbers, used neuroimaging rather than bedside testing and have not ... -
Does baseline depression increase the risk of unexplained and accidental falls in a cohort of community-dwelling older people? Data from The Irish Longitudinal Study on Ageing (TILDA).
(2018)Background: Depression independently increases the risk of falls in older people, but the mechanism for this relationship, as well as the specific falls type involved, remains unclear. Accidental falls (AFs) are due to ... -
What is the prevalence of untreated depression and death ideation in older people? Data from the Irish Longitudinal Study on Aging.
(2018)Objective: Late life depression (LLD) confers significant morbidity and mortality but is well recognized that it often goes undetected or untreated. The objective of this study is to quantify the burden of untreated depression ... -
Understanding the Impact of Metabolic Alterations on Brain Development
(Trinity College Dublin. School of Medicine. Discipline of Anatomy, 2025)Evaluating the metabolic requirements of neural stem cells, including the balance between glucose and ketone body utilisation, is important in understanding their role in brain development and disease. This study examined ... -
Cost and resource requirements for colorectal cancer screening in Ireland
(Trinity College Dublin. School of Medicine. Discipline of Public Health & Primary Care, 2025)Colorectal cancer (CRC) is a global public health problem. CRC screening reduces the colorectal cancer burden through the removal of precursor lesions and identifying the disease at an early stage. CRC screening is ... -
Orthostatic Hypotension and Cerebral Perfusion in Falls and Related Syncopal Disorders
(Trinity College Dublin. School of Medicine. Discipline of Medical Gerontology, 2025)Falls, syncope and orthostatic dizziness are common reasons for hospital presentations and are highly prevalent among older adults, leading to significant morbidity, loss of independence and increased healthcare utilisation. ...
