School of Medicine: Recent submissions
Now showing items 201-220 of 3444
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Examining the relationships between in-person and remote religious attendance and loneliness, quality of life, stress, and anxiety among older adults during COVID-19 in Ireland
(2024)Background Religious attendance has been shown to have a positive effect on psychological health among the older people (Moon & Kim, 2013). Due to COVID-19 lockdown restrictions and precautionary health advice, many ... -
Examining the relationship between religious involvementand psychological health, loneliness, and well-being duringthe COVID-19 pandemic among community dwelling older adults living in Ireland
(2024)During the COVID-19 pandemic and first lockdown in Ireland, public health restrictions created a barrier to in person religious participation. The aim of this paper is to understand the effect this had on psychological ... -
Investigating the influence of sex differences on modulation of neuroinflammation in the mouse by aerobic exercise
(Trinity College Dublin. School of Medicine. Discipline of Physiology, 2025)Exercise has long been viewed as an 'all-in-one' therapeutic approach by preserving and improving health and reducing the risk of age-associated noncommunicable metabolic, cardiovascular and neurodegenerative diseases ... -
Vitamin D and Hair: A review of current methods and validation of a quantitation method to measure 25(OH)D3 from hair
(Trinity College Dublin. School of Medicine. Discipline of Public Health & Primary Care, 2025)Introduction: Hair has emerged as a promising matrix for assessing endogenous steroid hormone levels, yet its potential for the quantitation of vitamin D remains unexploited. Vitamin D status is typically assessed by ... -
Hereditary Haemochromatosis: Hepatic and Cardiac Iron content and cardiac function at baseline and after a treatment course of venesection.
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2025)Background Hereditary haemochromatosis (HH) is the most common inherited genetic disorder in Europe1. Although there are several genetic mutations which can lead to the development of HH, the p.C282Y mutation (tyrosine ... -
The Role of Vascular Ultrasound in GCA-PMR Spectrum Disease
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2024)Background Timely and accurate identification of ‘GCA-PMR Spectrum Disease’ and its subsets is important so vascular complications can be averted. Traditional diagnostic and monitoring tools such as Temporal Artery ... -
The Impact of Driving Restrictions on People with Epilepsy in Ireland
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2025)Driving restrictions have a significant impact on patients with epilepsy and their families. This is documented in international studies but underreported in an Irish context. The goal of this study was to examine this ... -
Type 2 innate lymphoid cells are not involved in mouse bladder tumor development
(2024)Therapies for bladder cancer patients are limited by side effects and failures, highlighting the need for novel targets to improve disease management. Given the emerging evidence highlighting the key role of innate ... -
HARMONIOUS AGEING: A NARRATIVE REVIEW OF MUSIC THERAPY IN THE BIOMEDICAL LITERATURE
(2025)Purpose: As the global population of older adults rises, the United Nations Decade of Healthy Ageing (2021–2030) advocates for disease prevention, management, and enhancing overall wellbeing in older adults. We reviewed ... -
Gastrointestinal Bleeding Management and Utility of Clinical Scores in Predicting Disease and Outcome in a Modern European Population
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2025)Acute gastrointestinal bleeding remains a significant clinical challenge, with early risk stratification playing a critical role in guiding management decisions and optimizing patient outcomes. Risk scores, particularly ... -
Sarcopenia and Orthostatic Hypotension: Investigating the Underlying Haemodynamics
(Trinity College Dublin. School of Medicine. Discipline of Medical Gerontology, 2025)The ageing population worldwide is both one of the greatest successes of modern humanity and one of its greatest challenges. These challenges are numerous and include the geriatric syndromes of sarcopenia and orthostatic ... -
Folate and Vitamin B12 in The Irish Longitudinal Study on Ageing cohort: associations with cognitive function
(Trinity College Dublin. School of Medicine. Discipline of Medical Gerontology, 2024)The aim of this Ph.D. thesis is to examine nutrition, cognitive and autonomic dysfunction in the older population in Ireland. One review and five separate quantitative studies are presented in this thesis, which use data ... -
Sunshine genomics: a gene-environment interaction approach to the study of the genetic determinants of vitamin D status and skin cancer
(Trinity College Dublin. School of Medicine. Discipline of Public Health & Primary Care, 2025)Complex health traits are shaped by the interplay between genetic and environmental factors. Understanding the contributions of these factors is particularly important for traits such as vitamin D status and skin cancer ... -
Understanding T cell Immunity in Atopic Dermatitis: Relevance to Staphylococcus aureus Vaccine Design
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2025)In this thesis, I present original research investigating the T cell response to S. aureus in paediatric atopic dermatitis (AD). The aim of this study is to investigate the memory T cell immune response to S. aureus in ... -
Predictors and outcomes of adolescent alcohol and drug use: a scoping review
(Oxford Academic, 2024)Background: Adolescence is a pivotal life stage marked by educational advancement, entry into the workforce and formation of lasting relationships. Globally, adolescence is also the peak period during which individuals ... -
VINCI-AD: Investigating Transcutaneous Vagus Nerve Stimulation in Amnestic Mild Cognitive Impairment
(Trinity College Dublin. School of Medicine. Discipline of Medical Gerontology, 2025)Abstract Introduction New treatments are urgently needed for individuals with Mild Cognitive Impairment (MCI) - in particular for those with amnestic MCI as they are at highest risk for developing dementia. Transcutaneous ... -
Targeting DNA Damage Repair Deficiency in Pancreatic Cancer
(Trinity College Dublin. School of Medicine. Discipline of Surgery, School of Medicine, 2024)Pancreatic ductal adenocarcinoma is a lethal disease with a 5-year survival of <12%. Approximately 5-10% of the patients have BRCA1/2 mutations which cause homologous recombination (HR) deficiency and sensitise to cisplatin ... -
Clonal haematopoiesis in telomere biology disorders influences risk of haematological malignancy and overall survival
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2024)Telomere biology disorders (TBD) are a spectrum of diseases caused by germline variants in telomere repair and maintenance. They comprise one of the inherited bone marrow failure syndromes, a heterogenous group of disorders ... -
Inhibition of PP2A in a mono and co-culture model of hepatocelluar carcinoma : implications on the regulation of the matrix metalloproteinase system and the formation of the metastatic niche
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2016)Okadaic acid alteration in Hep3B cells Phosphoproteome: Cell proliferation was measured by MTT assay. Okadaic acid (OA; 40 nM) increased HepSB cells cell proliferation after 12, 24 and 48 h compared to untreated control ... -
Molecular mechanisms linking excess adipose tissue with esophageal cancer : targeting tumor metabolism and 5-lipoxygenase
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2017)Oesophageal adenocarcinoma (OAC) is the fastest growing cancer in the developed world. Visceral obesity, and in particular factors secreted from metabolically active visceral adipose tissue, may alter tumour glycolytic ...
